Branched-chain amino acids in liver diseases

doi:10.3748/wjg.v19.i43.7620

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Nov 21, 2013; 19(43): 7620-7629
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7620

Branched-chain amino acids in liver diseases

Kazuto Tajiri, Yukihiro Shimizu

Kazuto Tajiri, The Third Department of Internal Medicine, Toyama University Hospital, Toyama 930-0194, Japan

Yukihiro Shimizu, Gastroenterology Unit, Nanto Municipal Hospital, Toyama 932-0211, Japan

Author contributions: Tajiri K wrote the second half of the manuscript; and Shimizu Y wrote the first half of the manuscript and organized the whole manuscript.

Correspondence to: Yukihiro Shimizu, MD, PhD, Gastroenterology Unit, Nanto Municipal Hospital, Nanto, Toyama 932-0211, Japan. rsf14240@nifty.com

Telephone: +81-763-821475 Fax: +81-763-821853

Received: June 24, 2013
Revised: August 12, 2013
Accepted: September 15, 2013
Published online: November 21, 2013

Core Tip

Core tip: Advanced liver diseases are commonly accompanied by nutritional disturbances, which worsen the prognosis of the patients. Serum levels of branched-chain amino acids (BCAAs) are decreased in patients with liver cirrhosis, and the amino acids imbalance could affect the clinical picture of the disease and the prognosis of the patients. However, there are few comprehensive reviews on the biological activities of BCAAs. In this review, we summarize the biological activities of BCAAs, and discuss possible applications of BCAAs for the management of patients with advanced liver diseases with a list of clinical trials of BCAA administration.