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World J Gastroenterol. Nov 14, 2013; 19(42): 7399-7404
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7399
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7399
Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?
Raquel Francine Liermann Garcia, Simone Moreira, Leslie Ecker Ferreira, Christian Evangelista Garcia, Mauro de Souza Leite Pinho, Paulo Henrique Condeixa de França, Departamento de Medicina, Universidade da Região de Joinville/Univille, Joinville, 89219-719 Santa Catarina, Brazil
Raquel Francine Liermann Garcia, Christian Evangelista Garcia, Departamento de Clinica Médica e Cirurgia Geral Hospital Municipal São José, Joinville, 89202-000 Santa Catarina, Brazil
Ana Lucia de Araújo Ramos, Cristiane Alves Villela-Nogueira, Departamento de Clínica Médica, Serviço de Hepatologia, Faculdade de Medicina/Hospital Universitário Clementino Fraga Filho/Universidade Federal do Rio de Janeiro, 21941-913 Rio de Janeiro, Brazil
Angelo Alves de Mattos, Cristiane Valle Tovo, Serviço de Gastroenterologia e Hepatologia, Irmandade da Santa Casa de Misericórdia/ISCMPA, Porto Alegre, 90020-090 Rio Grande do Sul, Brazil
Lysandro Alsina Nader, Serviço de Endoscopia, Universidade Federal de Pelotas/UFPel, Pelotas, 96010-610 Rio Grande do Sul, Brazil
Juliene Antonio Ramos, Edson Rondinelli, Instituto de Biofísica Carlos Chagas Filho/UFRJ, 21941-902 Rio de Janeiro, Brazil
Arnaldo de Jesus Dominici, Departamento de Gastroenterologia, Hospital Universitário da Universidade Federal do Maranhão/UFMA, São Luis, 65020-560 Maranhão, Brazil
Carlos Eduardo Brandão-Mello, Serviço de Gastroenterologia, Hospital Universitário Gaffrée Guinle/HUGG/UNIRIO, 20270-004 Rio de Janeiro, Brazil
Author contributions: Garcia RFL, Moreira S, Ferreira LE, Pinho MSL and França PHC contributed equally to the study conception and performance, interpretation of data, and writing of the manuscript; Garcia CE performed the statistical analysis and critically reviewed the manuscript for intellectual content; Ramos ALA, de Mattos AA, Tovo CV, Nader LA, Ramos JA, Rondinelli E, Dominici AJ, Brandão-Mello CE and Villela-Nogueira CA contributed equally to the acquisition and analysis of patients’ data.
Supported by Grants from the Research Fund from University of Region of Joinville, FAP-UNIVILLE
Correspondence to: Raquel Francine Liermann Garcia, MD, Departamento de Medicina, Universidade da Região de Joinville/Univille, Rua Paulo Malschitzki, 10, Campus Universitário-Zona Industrial, Joinville, 89219-719 Santa Catarina, Brazil. drargarcia@terra.com.br
Telephone: +55-47-99811610 Fax: +55-47-30291877
Received: January 21, 2013
Revised: August 19, 2013
Accepted: September 4, 2013
Published online: November 14, 2013
Revised: August 19, 2013
Accepted: September 4, 2013
Published online: November 14, 2013
Core Tip
Core tip: This study investigated the differential distribution of interleukin 28B genetic variants between patients with chronic hepatitis C genotype 1 infection and non-infected healthy controls, and evaluated the association of these polymorphisms with patient response to standard antiviral therapeutic regimens. Genotype and allele frequencies of rs12979860 and rs8099917 were significantly different between the patients and controls, and the patterns suggested a potential protective role against hepatitis C virus infection. Finally, the rs12979860 CC genotype showed correlation to achievement of sustained virological response following pegylated-interferon/ribavirin-based therapy.