1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells

doi:10.3748/wjg.v19.i42.7374

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 42

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6406)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-6) series.

Item

Count

PDF

487

HTML

4228

Figures (1-6)

167

Sum=4882

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

689

Download

835

Sum=1524

Nov 14, 2013 (publication date) through May 9, 2024

Times Cited of This Article

Times Cited (29)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Nov 14, 2013; 19(42): 7374-7388
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7374

1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells

Dipon Das, Ranjan Preet, Purusottam Mohapatra, Shakti Ranjan Satapathy, Chanakya Nath Kundu

Dipon Das, Ranjan Preet, Purusottam Mohapatra, Shakti Ranjan Satapathy, Chanakya Nath Kundu, Cancer Biology Division, KIIT School of Biotechnology, KIIT University, Bhubaneswar, Odisha 751024, India

Author contributions: Das D carried out all the experiments and wrote the first draft of the manuscript; Preet R, Mohapatra P and Satapathy SR performed the statistical analysis and were involved in editing the manuscript; Kundu CN designed the study and wrote the manuscript.

Supported by Indian Council of Medical Research and Department of Biotechnology, Government of India

Correspondence to: Chanakya Nath Kundu, Assistant professor, Cancer Biology Division, KIIT School of Biotechnology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India. cnkundu@gmail.com

Telephone: +91-674-2725466 Fax: +91-674-2725732

Received: December 19, 2012
Revised: April 25, 2013
Accepted: June 5, 2013
Published online: November 14, 2013

Core Tip

Core tip: 5-fluorouracil (5-FU) resistance in colon cancer patients is a common phenomenon that requires immediate resolution. In this paper, we used two commonly administered clinical drugs, 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) and Resveratrol (Res), and studied their effects on 5-FU sensitive and resistance colon cancer cells. The drug combination was more effective in 5-FU resistant cells than in 5-FU sensitive cells and was more effective than the individual treatments. The BCNU-Res combination mediated its action by compromising the base excision repair cascade. This combination might be useful for treatment of 5-FU resistant colon cancer patients.