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World J Gastroenterol. Oct 28, 2013; 19(40): 6774-6783
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6774
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6774
Risk of ileal pouch neoplasms in patients with familial adenomatous polyposis
Masahiro Tajika, Yasumasa Niwa, Tsutomu Tanaka, Makoto Ishihara, Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan
Vikram Bhatia, Department of Medical Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India
Kenji Yamao, Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya 464-8681, Japan
Author contributions: Tajika M contributed to study conception and design, analysis and interpretation of the data, and drafting of the article; Niwa Y and Yamao K contributed to critical revision of the article for important intellectual content and final approval of the article; Bhatia V contributed to critical revision of the article and drafting of the article; Tanaka T and Ishihara M collected and interpreted the data.
Correspondence to: Masahiro Tajika, MD, PhD, Department of Endoscopy, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. mtajika@aichi-cc.jp
Telephone: +81-52-7626111 Fax: +81-52-7635233
Received: June 26, 2013
Revised: August 14, 2013
Accepted: August 17, 2013
Published online: October 28, 2013
Revised: August 14, 2013
Accepted: August 17, 2013
Published online: October 28, 2013
Core Tip
Core tip: To eliminate the risk of colorectal cancer, the majority of patients with familial adenomatous polyposis (FAP) are treated with restorative proctocolectomy and an ileal pouch-anal anastomosis. However, as these patients are followed-up for longer intervals, it has gradually become recognized that adenomas and adenocarcinomas may develop in the ileal pouch. If the standard-of-care surgery for FAP patients does not eliminate all cancer risk, surgical and follow-up strategies may need to be altered. In this review, we summarize the data from the published English literature regarding the incidence of adenomas and carcinomas in the ileal pouch after proctocolectomy in FAP patients.