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World J Gastroenterol. Oct 7, 2013; 19(37): 6193-6198
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6193
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6193
Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: Is gastroparesis a factor?
Anna Tavakkoli, Bisma A Sayed, Nicholas J Talley, Baharak Moshiree, Department of Medicine, Columbia University Medical Center, New York, NY 10019, United States
Bisma A Sayed, Department of Sociology, University of Miami, Miami, FL 33136, United States
Nicholas J Talley, Faculty of Health, University of Newcastle, Newcastle, NSW 2308, Australia
Baharak Moshiree, Department of Gastroenterology, University of Miami, Miami, FL 33136, United States
Author contributions: Tavakkoli A contributed to the data analysis, drafting and editing of manuscript; Sayed BA contributed to the statistical analysis; Talley NJ contributed to the reviewing and editing of manuscript; Moshiree B conceived and designed project and editing of manuscript.
Correspondence to: Baharak Moshiree, MD, Department of Gastroenterology, University of Miami, 1475 NW 12th Ave, 1st floor, Miami, FL 33136, United States. bmoshiree@med.miami.edu
Telephone: +1-305-2438644 Fax: +1-305-2433762
Received: June 13, 2013
Revised: July 14, 2013
Accepted: July 17, 2013
Published online: October 7, 2013
Revised: July 14, 2013
Accepted: July 17, 2013
Published online: October 7, 2013
Core Tip
Core tip: Gastroparesis (GP) has been thought to occur in about 8%-10% of patients who suffer from refractory gastroesophageal reflux disease (GERD). There have been no formal studies to date that have evaluated whether patients with refractory GERD additionally suffer from GP. Our study aimed to investigate whether patients who experience continued symptoms of GERD despite acid suppression therapy also concurrently have gastroparesis. By using multichannel intraluminal impedance pH technology, we were not able to find an association between patients with refractory GERD and gastroparesis.