Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Sep 28, 2013; 19(36): 6084-6092
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6084
Published online Sep 28, 2013. doi: 10.3748/wjg.v19.i36.6084
Overexpression of insulin-like growth factor-I receptor as a pertinent biomarker for hepatocytes malignant transformation
Xiao-Di Yan, Hai-Jian Zhang, Deng-Fu Yao, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Min Yao, Li Wang, Mei-Juan Yan, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China
Xing Gu, Yun Shi, Jie Chen, Department of Clinical Oncology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Zhi-Zhen Dong, Department of Diagnostics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Yan XD and Yao M contributed equally to this work, designed research, analyzed data and wrote the paper; Wang L, Yan MJ and Gu X carried out the experiments; Yao M, Shi Y, Chen J, Zhang HJ and Yan XD performed the experiments; Xing Gu completed immunohistochemical and HE staining; Dong ZZ made critical review of the manuscript; Yao DF is the guarantor.
Supported by The Society Development of Nantong, HS2012039; Jiangsu Health Projects, BL2012053, K201102; the Priority Academic Program Development of Jiangsu, and the International S and T Cooperation Program, 2013DFA32150 of China
Correspondence to: Deng-Fu Yao, MD, PhD, Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com
Telephone: +86-513-85052297 Fax: +86-513-85052254
Received: June 15, 2013
Revised: July 20, 2013
Accepted: August 20, 2013
Published online: September 28, 2013
Revised: July 20, 2013
Accepted: August 20, 2013
Published online: September 28, 2013
Core Tip
Core tip: The abnormality of insulin-like growth factor-I receptor (IGF-IR) expression was progressively increased in hepatocarcinogenesis at mRNA or protein level, and there was a positive correlation between circulating blood and liver IGF-IR, suggesting that the over-expression of liver IGF-IR release into blood, and serum IGF-IR should be an early useful marker for monitoring malignant transformation of rat hepatocytes.