Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Apr 7, 2013; 19(13): 2065-2072
Published online Apr 7, 2013. doi: 10.3748/wjg.v19.i13.2065
Increased endothelin receptor B and G protein coupled kinase-2 in the mesentery of portal hypertensive rats
Qing-Hong Du, Lin Han, Jun-Jie Jiang, Peng-Tao Li, Xin-Yue Wang, Xu Jia
Qing-Hong Du, Lin Han, Jun-Jie Jiang, Peng-Tao Li, Xin-Yue Wang, Xu Jia, Department of Pathology, School of Fundamental Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
Author contributions: Li PT proposed the study; Li PT and Du QH performed research and wrote the first draft; Han L collected and analyzed the data; all authors contributed to the design and interpretation of the study and to further drafts; Li PT is the guarantor.
Supported by Grant from National Key New Drug Creation Project of China, No. 2009ZX09102
Correspondence to: Dr. Peng-Tao Li, Department of Pathology, School of Fundamental Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, China. lipengtao0413@hotmail.com
Telephone: +86-10-64287015 Fax: +86-10-64287015
Received: October 23, 2012
Revised: January 25, 2013
Accepted: February 5, 2013
Published online: April 7, 2013
Core Tip

Core tip: Portal hypertension (PHT) is a life-threatening condition which frequently develops in patients with liver cirrhosis, and has limited treatment options. For many years, endothelin-1 (ET-1) has received considerable interest in the area of liver cirrhosis for its potential contribution to PHT. The aim of the present study was to directly examine the expression of ET-1 and its receptors in the mesentery of rats with PHT, and to clarify how the ET-1 signaling system changed with the development of PHT.