Clinical Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 15, 2003; 9(10): 2308-2312
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2308
Seroreactivity against Saccharomyces cerevisiae in patients with Crohn’s disease and celiac disease
Zsolt Barta, István Csípõ, Gábor G. Szabó, Gyula Szegedi
Zsolt Barta, István Csípõ, Gábor G. Szabó, Gyula Szegedi, 3rd Department of Medicine, University of Debrecen, Móricz Zs. Krt. 22. 4004 Debrecen, Hungary
Author contributions: All authors contributed equally to the work.
Correspondence to: Zsolt Barta, M.D., 3rd Department of Medicine, University of Debrecen, Móricz Zs. Krt.22. 4004 Debrecen, Hungary. mailto:barta@iiibel.dote.hu
Telephone: +36-52-453-337 Fax: +36-52-414-969
Received: March 12, 2003
Revised: May 2, 2003
Accepted: May 9, 2003
Published online: October 15, 2003
Abstract

AIM: To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease.

METHODS: A cohort of patients with inflammatory bowel diseases (42 patients with Crohn’s disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16 patients) from Debrecen, Hungary were enrolled in the study. The diagnosis was made using the formally accepted criteria. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), antiendomysium antibodies (EMA), antigliadin antibodies (AGA) and anti human tissue transglutaminase antibodies (tTGA) were investigated.

RESULTS: The results showed that ASCA positivity occurred not only in Crohn’s disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved.

CONCLUSION: It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn’s disease.

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