Letter to the Editor
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2023; 29(34): 5091-5093
Published online Sep 14, 2023. doi: 10.3748/wjg.v29.i34.5091
Gastrointestinal microbiome and cholelithiasis: Prospect in the nervous system
Mirella Mancha Chahuara, Leidhy Dhy Maruja Lopez Tufino, Carlos Andrés Mugruza-Vassallo
Mirella Mancha Chahuara, Leidhy Dhy Maruja Lopez Tufino, Carlos Andrés Mugruza-Vassallo, Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Lima Chorrillos 15067, Lima, Peru
Author contributions: Lopez Tufino LDM drafted a study on gastrointestinal microbiome and cholelithiasis, reviewed literature, and wrote an initial version of the paper; Mancha Chahuara M drafted study on gastrointestinal microbiome and cholelithiasis, reviewed literature, and wrote initial version of the paper; Mugruza-Vassallo CA reviewed and criticized gastrointestinal microbiome and cholelithiasis, he added the prospect in the nervous systems and corrected the paper.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos Andrés Mugruza-Vassallo, PhD, Senior Lecturer, Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista, Ex Hacienda Villa, Av José Antonio Lavalle N° 302, Lima Chorrillos 15067, Lima, Peru. cmugruza@yahoo.com
Received: June 9, 2023
Peer-review started: June 9, 2023
First decision: July 23, 2023
Revised: July 25, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 14, 2023
Abstract

Dan and colleagues recently published research suggesting that the gastrointestinal microbiome (microorganisms and metabolites) in cholelithiasis. They reviewed gallbladder stones, choledocholithiasis, and asymptomatic gallstones. Finally, their discussion was on the gastrointestinal. We focused on complementing the effect of the S1 protein and neuroinflammatory changes caused by severe acute respiratory syndrome coronavirus 2. Our contribution was about to involve the microbiota and the nervous system. They can have similar functions because they have similar pathways and advantages, bearing in mind γ-aminobutyric acid in schizophrenia and serotonin in Parkinson's disease. Therefore in the next few years, more research should be encouraged on the microbiota consequences for development, and mobility.

Keywords: Gastrointestinal microbiome, γ-aminobutyric acid, Serotonin, Letter

Core Tip: The microbiota and the nervous system can have similar functions because they have similar advantages. Bearing in mindγ-aminobutyric acid (GABA) in schizophrenia and serotonin in Parkinson's disease and GABA and serotonin management, we expect in the next few years, more research should be encouraged on the microbiota consequences for development, and mobility.