Randomized Clinical Trial
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2015; 21(8): 2490-2496
Published online Feb 28, 2015. doi: 10.3748/wjg.v21.i8.2490
Clinical observations on the treatment of prolapsing hemorrhoids with tissue selecting therapy
Zhi-Gang Wang, Yong Zhang, Xian-Dong Zeng, Tie-Hui Zhang, Qi-Dong Zhu, De-Long Liu, Yun-Yu Qiao, Nan Mu, Zhi-Tao Yin
Zhi-Gang Wang, Yong Zhang, Xian-Dong Zeng, Tie-Hui Zhang, Qi-Dong Zhu, De-Long Liu, Yun-Yu Qiao, Nan Mu, Zhi-Tao Yin, The 5th Department of Anorectal Disease, Shenyang Coloproctology Hospital, Shenyang 110002, Liaoning Province, China
Author contributions: Wang ZG performed the majority of the clinical therapy and data analysis, and wrote the paper; Zhang Y advised the design and performance of the study; Zeng XD, Zhang TH and Zhu QD performed ethical supervision and provided the effect evaluation system; Liu DL, Qiao YY and Mu N performed the follow-up and the initial data analysis; Yin ZT designed the study, provided the funding, and is responsible for the paper’s reliability.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Tao Yin, MD, PhD, The 5th Department of Anorectal Disease, Shenyang Coloproctology Hospital, No. 9 Nanjingbei Street, Heping District, Shenyang 110002, Liaoning Province, China. yinzitao@163.com
Telephone: +86-24-22511990 Fax: +86-24-22533338
Received: August 24, 2014
Peer-review started: August 24, 2014
First decision: September 27, 2014
Revised: October 29, 2014
Accepted: December 8, 2014
Article in press: December 8, 2014
Published online: February 28, 2015
Processing time: 188 Days and 6.3 Hours
Abstract

AIM: To compare the effects and postoperative complications between tissue selecting therapy stapler (TST) and Milligan-Morgan hemorrhoidectomy (M-M).

METHODS: Four hundred and eighty patients with severe prolapsing hemorrhoids, who were admitted to the Shenyang Coloproctology Hospital between 2009 and 2012, were randomly divided into observation (n = 240) and control (n = 240) groups. Hemorrhoidectomies were performed with TST in the observation group and with the M-M technique in the control group. The therapeutic effects, operation security, and postoperative complications in the two groups were compared. The immediate and long-term complications were assessed according to corresponding criteria. Pain was assessed on a visual analogue scale. The efficacy was assessed by specialized criteria. The follow-up was conducted one year after the operation.

RESULTS: The total effective rates of the observation and control groups were 99.5% (217/218) and 98.6% (218/221) respectively; the difference was not statistically significant (P = 0.322). Their were significant differences between observation and control groups in intraoperative blood loss (5.07 ± 1.14 vs 2.45 ± 0.57, P = 0.000), pain (12 h after the surgery: 5.08 ± 1.62 vs 7.19 ± 2.01, P = 0.000; at first dressing change: 2.64 ± 0.87 vs 4.34 ± 1.15, P = 0.000; first defecation: 3.91 ± 1.47 vs 5.63 ± 1.98, P = 0.001), urine retention (n = 22 vs n = 47, P = 0.001), anal pendant expansion after the surgery (2.35 ± 0.56 vs 5.16 ± 1.42, P = 0.000), operation time (18.3 ± 5.6 min vs 29.5 ± 8.2 min, P = 0.000), and the length of hospital stay (5.3 ± 0.6 d vs 11.4 ± 1.8 d, P = 0.000). Moreover TST showed significant reductions compared to M-M in the rates of long-term complications such as fecal incontinence (n = 3 vs n = 16, P = 0.003), difficult bowel movement (n = 1 vs n = 9, P = 0.011), intractable pain (n = 2 vs n = 12, P = 0.007), and anal discharge (n = 3 vs n = 23, P = 0.000).

CONCLUSION: TST for severe prolapsing hemorrhoids is a satisfactory technique for more rapid recovery, lower complication rates, and higher operation security.

Keywords: Complication rate; Milligan-Morgan hemorrhoidectomy; Operation security; Severe prolapsing hemorrhoids; Tissue selecting therapy stapler

Core tip: Tissue selecting therapy staplers are increasingly used in clinics as a minimally invasive technique for treating hemorrhoids, based on the formation mechanism and physiologic and pathologic structural changes of hemorrhoids. This method protects anal cushions and functions. In this study, 480 patients with severe prolapsing hemorrhoids, who were admitted to the Shenyang Anorectal Hospital, were treated with this method or by Milligan-Morgan hemorrhoidectomy. The efficacy of both methods was assessed one year after the operation. The therapeutic effects, operation security, and postoperative complications from the two treatment methods were compared.