This Article

  Case Report
Copyright ©2014 Baishideng Publishing Group Co.

One case of intrahepatic cholangiocarcinoma amenable to resection after radioembolization
Cecilia Servajean, Marine Gilabert, Gilles Piana, Geneviève Monges, Jean-Robert Delpero, Isabelle Brenot, Jean-Luc Raoul
Cecilia Servajean, Marine Gilabert, Jean-Luc Raoul, Department of Medical Oncology, Paoli-Calmettes Institute, 13273 Marseille, France
Gilles Piana, Department of Radiology, Paoli-Calmettes Institute, 13273 Marseille, France
Geneviève Monges, Department of Pathology, Paoli-Calmettes Institute, 13273 Marseille, France
Jean-Robert Delpero, Department of Digestive Surgery, Paoli-Calmettes Institute, 13273 Marseille, France
Isabelle Brenot, Department of Nuclear Medicine, Paoli-Calmettes Institute, 13273 Marseille, France
Author contributions: All authors participated in the diagnosis, management and follow-up of this clinical case and have reviewed, corrected and approved this final version of the manuscript.
Correspondence to: Jean-Luc Raoul, Professor, Department of Medical Oncology, Paoli-Calmettes Institute, 232 Boulevard de Sainte Marguerite, BP 156, 13273 Marseille, France.
Telephone: +33-4-91223679 Fax: +33-4-91223670
Received: November 15, 2013
Revised: December 25, 2013
Accepted: February 20, 2014
Published online: May 7, 2014

We report the case of a 57-year-old man who was diagnosed with a large unresectable cholangiocarcinoma associated with 2 satellite nodules and without clear margins with the right hepatic vein. Despite 4 cycles of GEMOX (stopped due to a hypertransaminasemia believed to be due to gemcitabine) and 4 cycles of FOLFIRINOX, the tumor remained stable and continued to be considered unresectable. Radioembolization (resin microspheres, SIRS-spheres®) targeting the left liver (474 MBq) and segment IV (440 MBq) was performed. This injection was very well tolerated, and 4 more cycles of FOLFIRINOX were given while waiting for radioembolization efficacy. On computed tomography scan, a partial response was observed; the tumor was far less hypervascularized, and a margin was observed between the tumor and the right hepatic vein. A left hepatectomy enlarged to segment VIII was performed. On pathological exam, most of the tumor was acellular, with dense fibrosis around visible microspheres. Viable cells were observed only at a distance from beads. Radioembolization can be useful in the treatment of cholangiocarcinoma, allowing in some cases a secondary resection.