Copyright
©The Author(s) 1996. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 1996; 2(Suppl1): 221-221
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.221
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.221
Omeprazole treatment for severe gastroesophageal reflux disease
Ying Zhao, Fang Hou, Jin-Ying Wang, Hong-Wei Tian, The Hospital of School for Health Care of Benxi Steel and Iron Company, Benxi, Liaoning Province, China
Author contributions: All authors contributed equally to the work.
Received: December 11, 1995
Revised: January 21, 1996
Accepted: July 19, 1996
Published online: September 15, 1996
Revised: January 21, 1996
Accepted: July 19, 1996
Published online: September 15, 1996
Abstract
AIM: More than half a century, many patients suffering from the severe gastroesophageal reflux disease (GERD). In the past, the medical management was ineffective. In contrast, the proton pump inhibitor omeprazole has recently been shown to be effective and safe for treatment of severe reflux disease.
METHODS: 125 patients with GERD were treated by omeprazole 0.5-0.8 mg/kg/d, for 1/2 year.
RESULTS: After one week, 24-h intraesophageal pH returned steadly to normal. Half a year later, all patients had relief of symptoms. We also found, the long term treatment of omeprazole is necessary and heal severe GERD and prevent complications.
CONCLUSION: Omeprazole is very effective to heal GERD.
Keywords: Gastroesophageal reflux disease, Omeprazole