Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.154
Revised: January 21, 1996
Accepted: July 19, 1996
Published online: September 15, 1996
AIM: Gastric acid hypersecretion is a main mechanism in genesis of duodenal ulcer (DU). Rapid gastric emptying and impaired acid inhibition of gastric emptying has been reported in DU patients. It is possible that accelerated gastric emptying play a role in genesis of DU by increasing the effective acid load delivered to duodenum, our aim is to study the interdigestive and postcibal motility of gastrum and duodenum on DU patients.
METHODS: 11 DU patients and 12 healthy subjects were chose, gastric and duodenal intraluminal pressure was measured by catheter perfusion technique. Interdigestive motility was recorded for 3 h, postcibal motility was recorded for 1.5 h. Mean frequency, mean amplitude and motility index of antral and duodenal contraction were calculated in fasting and fed states, respectively. The number of phase three found and propagation patterns were recorded in interdigestive state.
RESULTS: In fasting state, the frequency of gastric antral contraction was higher in DU group than in healthy controls (P < 0.05), amplitude showed no difference, 41 phase three contraction was found in DU, only 18 phase 3 was fond in control group, the cycle of IDMC was shorter in DU than in healthy subjects, phase 3 with abnormal conduction (retrograde or not propagation, accounting for 70.7%) increased more in DU than in controls (27.8%).
CONCLUSION: Accelerated gastric antral motility is present in DU patients, manifested as increase of antral contraction number and shorting of IDMC cycle. Coordinate contraction of stomach and duodenum is impaired in DU, increased phase three number of abnormal conduction is one of its manifestations.