Copyright
©The Author(s) 1996. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 25, 1996; 2(1): 25-26
Published online Mar 25, 1996. doi: 10.3748/wjg.v2.i1.25
Published online Mar 25, 1996. doi: 10.3748/wjg.v2.i1.25
Clinical significance of immunohistochemical study of p53 protein in colorectal carcinoma
Da-Wei Chen, Yuan-He Wang, Xue-Yun Chen, Han Gao, Qiang Wang, Department of general Surgery, Changzheng Hospital, Second Military Medical University, 415 Feng Yang road, Shanghai 200003, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Da-Wei Chen, Department of general Surgery, Changzheng Hospital, Second Military Medical University, 415 Feng Yang road, Shanghai 200003, China
Received: September 16, 1995
Revised: October 31, 1995
Accepted: December 1, 1995
Published online: March 25, 1996
Revised: October 31, 1995
Accepted: December 1, 1995
Published online: March 25, 1996
Abstract
AIM: To determine the clinical significance of p53 protein expression in colorectal carcinoma.
METHODS: The expression of p53 protein was examined in 92 colorectal carcinomas using the monoclonal antibody PAb 1801. Correlation between p53 protein expression and prognosis in colorectal carcinoma was analyzed using the log-rank test.
RESULTS: The frequency of p53 protein expression was 57.61%, corresponding with Dukes' stage of bowel cancer. Analysis of survivor data demonstrated that the survival rate of the colorectal carcinoma with positive staining for p53 protein was lower than that of group with negative staining.
CONCLUSION: Expression of p53 protein is correlated with poor prognosis in colorectal carcinoma.
Keywords: Colorectal neoplasms, Oncogenes, Protein p53, Immunohistochemistry