Relationship between RGS5 expression and differentiation and angiogenesis of gastric carcinoma

doi:10.3748/wjg.v16.i44.5642

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Nov 28, 2010 (publication date) through May 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 28, 2010; 16(44): 5642-5646
Published online Nov 28, 2010. doi: 10.3748/wjg.v16.i44.5642

Relationship between RGS5 expression and differentiation and angiogenesis of gastric carcinoma

Jing-Hua Wang, Wei-Sun Huang, Cheng-Ru Hu, Xiao-Xiang Guan, Hang-Bo Zhou, Long-Bang Chen

Jing-Hua Wang, Wei-Sun Huang, Cheng-Ru Hu, Xiao-Xiang Guan, Long-Bang Chen, Department of Oncology, Nanjing General Hospital of Nanjing Military Command, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China

Hang-Bo Zhou, Department of Pathology, Nanjing General Hospital of Nanjing Military Command, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China

Author contributions: Wang JH and Chen LB designed the research; Huang WS and Hu CR performed the research; Zhou HB performed pathologic re-examination; Huang WS evaluated data and prepared the manuscript; Wang JH, Guan XX and Chen LB are involved in the manuscript writing.

Supported by Grants from National Natural Science Foundation of China, No. 30870962

Correspondence to: Long-Bang Chen, Professor, Department of Oncology, Nanjing General Hospital of Nanjing Military Command, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China. chenlongbang@yeah.net

Telephone: +86-25-80860123 Fax: +86-25-80860123

Received: June 5, 2010
Revised: July 10, 2010
Accepted: July 17, 2010
Published online: November 28, 2010

Abstract

AIM: To explore the regulator of G-protein signaling 5 (RGS5) expression in gastric carcinoma and its association with differentiation and microvascular density (MVD).

METHODS: Expression of RGS5 and CD34 were examined in 76 cases of gastric carcinoma, including 22 cases with lymph node metastasis and 54 cases without lymph node metastasis determined by immunohistochemistry (IHC). MVD was assessed using CD34 monoclonal antibody. The presence of RGS5 and CD34 was analyzed by IHC using the Envision technique.

RESULTS: The RGS5 expression in gastric carcinoma was positively correlated with the differentiation of the tumor (r = 0.345, P < 0.001), but not related with age, gender, tumor size, clinical stage and lymph node metastasis (P > 0.05). The average MVD in the group with lymph node metastasis was significantly higher than that in the group without lymph node metastasis (P < 0.05). RGS5 expression was negatively correlated with the average MVD (P < 0.05).

CONCLUSION: RGS5 expression level in gastric carcinoma is associated with the differentiation and MVD of the tumor, and may be used as an important parameter for determining the prognosis of gastric carcinoma patients.

Keywords: RGS5 expression, Gastric carcinoma, Differentiation, Microvascular density