Kristinsson JO, Westerveld PV, Morsche RHT, Roelofs HM, Wobbes T, Witteman BJ, Tan AC, Oijen MGV, Jansen JB, Peters WH. Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. World J Gastroenterol 2009; 15(28): 3493-3497 [PMID: 19630103 DOI: 10.3748/wjg.15.3493]
Corresponding Author of This Article
Wilbert HM Peters, PhD, Department of Gastroenterology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. w.peters@mdl.umcn.nl
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World J Gastroenterol. Jul 28, 2009; 15(28): 3493-3497 Published online Jul 28, 2009. doi: 10.3748/wjg.15.3493
Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma
Jón O Kristinsson, Paul van Westerveld, Rene HM te Morsche, Hennie MJ Roelofs, T Wobbes, Ben JM Witteman, Adriaan CITL Tan, Martijn GH van Oijen, Jan BMJ Jansen, Wilbert HM Peters
Jón O Kristinsson, Paul van Westerveld, Rene HM te Morsche, Hennie MJ Roelofs, Martijn GH van Oijen, Jan BMJ Jansen, Wilbert HM Peters, Department of Gastroenterology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
T Wobbes, Department of Surgery, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Ben JM Witteman, Department of Gastroenterology, Hospital Gelderse Vallei, PO Box 9025, 6710 HN, Ede, The Netherlands
Adriaan CITL Tan, Department of Gastroenterology, Canisius Wilhelmina Hospital, Weg door Jonkerbos 100, 6532 SZ, Nijmegen, The Netherlands
Author contributions: Kristinsson JO, Jansen JBMJ and Peters WHM designed the research; Kristinsson JO, Wobbes T, Witteman BJM and Tan ACITL included the patients and provided clinical advice; van Westerveld P, te Morsche RHM and Roelofs HMJ performed the analyses; van Oijen MGH and te Morsche RHM were responsible for the data analysis and corrected the manuscript; Kristinsson JO and Peters WHM wrote the paper.
Correspondence to: Wilbert HM Peters, PhD, Department of Gastroenterology, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. w.peters@mdl.umcn.nl
Telephone: +31-24-3616316
Fax: +31-24-3540103
Received: April 17, 2009 Revised: June 12, 2009 Accepted: June 19, 2009 Published online: July 28, 2009
Abstract
AIM: To determine whether -1195 A→G and/or -765 G→C polymorphisms in Cyclooxygenase-2 (COX-2) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.
METHODS: Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated.
RESULTS: The distribution of the -1195 A→G polymorphism was significantly different in esophageal cancer patients compared to controls. The -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma (OR = 3.85, 95% CI: 1.45-10.3) compared with the -1195 AA genotype as a reference. The -765 G→C genotype distribution was not different between the two groups. The GG/GG haplotype was present more often in esophageal adenocarcinoma patients than in controls (OR = 3.45, 95% CI: 1.24-9.58; with AG/AG as a reference). The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance.
CONCLUSION: Presence of the COX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.
