Khan R, Hamid S, Abid S, Jafri W, Abbas Z, Islam M, Shah H, Beg S. Predictive factors for early aspiration in liver abscess. World J Gastroenterol 2008; 14(13): 2089-2093 [PMID: 18395912 DOI: 10.3748/wjg.14.2089]
Corresponding Author of This Article
Dr. Saeed Hamid, MBBS, FRCP, FRCPI, FACP, FACG, Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan. khan.rustam@aku.edu
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Rapid Communication
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World J Gastroenterol. Apr 7, 2008; 14(13): 2089-2093 Published online Apr 7, 2008. doi: 10.3748/wjg.14.2089
Predictive factors for early aspiration in liver abscess
Rustam Khan, Saeed Hamid, Shahab Abid, Wasim Jafri, Zaigham Abbas, Mohammed Islam, Hasnain Shah, Shaalan Beg
Rustam Khan, Saeed Hamid, Shahab Abid, Wasim Jafri, Zaigham Abbas, Mohammed Islam, Shaalan Beg, Hasnain Shan, Section of Gastroenterology Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan
Author contributions: Khan R collected and entered the data on SPSS software, did literature searches and wrote manuscript drafts; Hamid S coordinated data interpretation, drafted and wrote the manuscript; Abid S conceived the idea, designed the study, helped in drafting and writing the manuscript; Jafri W helped in data interpretation, general support, drafting and manuscript writing; Abbas Z helped in data interpretation and manuscript writing; Islam M Performed the statistical analysis; Shan H helped in drafting and manuscript writing; Beg S helped in data collection and manuscript writing.
Correspondence to: Dr. Saeed Hamid, MBBS, FRCP, FRCPI, FACP, FACG, Department of Medicine, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan. khan.rustam@aku.edu
Telephone: +92-21-4930051-4672
Fax: +92-21-4934294
Received: September 27, 2007 Revised: December 8, 2007 Published online: April 7, 2008
Abstract
AIM: To determine the predictive factors for early aspiration in liver abscess.
METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess.
RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group.
CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology.
