Case Report
Copyright ©2007 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 21, 2007; 13(23): 3255-3258
Published online Jun 21, 2007. doi: 10.3748/wjg.v13.i23.3255
Hyperplastic polyposis associated with two asynchronous colon cancers
Masaya Kurobe, Kuniko Abe, Naoe Kinoshita, Masanobu Anami, Hirotaka Tokai, Yoshinori Ryu, Chun Yang Wen, Takashi Kanematsu, Tomayoshi Hayashi
Masaya Kurobe, Kuniko Abe, Naoe Kinoshita, Masanobu Anami, Yoshinori Ryu, Tomayoshi Hayashi, Department of Pathology, Nagasaki University Hospital, Nagasaki 852-8501, Japan
Hirotaka Tokai, Takashi Kanematsu, Department of Trans-plantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852-8501, Japan
Chun Yang Wen, Department of Digestive Disease Center, Bei Hua University, 3999 Huashan Road, Jilin 132013, Jilin Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Tomayoshi Hayashi, MD, PhD, De-partment of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. toma@nagasaki-u.ac.jp
Telephone: +81-95-8497561 Fax: +81-95-8497564
Received: March 2, 2007
Revised: April 1, 2007
Accepted: April 4, 2007
Published online: June 21, 2007
Abstract

We report a patient with hyperplastic polyposis who had two asynchronous colon cancers, a combined adenoma-hyperplastic polyp, a serrated adenoma, and tubular adenomas. Hyperplastic polyposis is thought to be a precancerous lesion; and adenocarcinoma arises from hyperplastic polyposis through the hyperplastic polyp-adenoma-carcinoma sequence. Most polyps in patients with hyperplastic polyposis present as bland-looking hyperplastic polyps, which are regarded as non-neoplastic lesions; however, the risk of malignancy should not be underestimated. In patients with multiple hyperplastic polyps, hyperplastic polyposis should be identified and followed up carefully in order to detect malignant transformation in the early stage.

Keywords: Hyperplastic polyposis, Hyperplastic polyp, Adenocarcinoma, Serrated adenoma, Multiple cancer