Relationship between metabolic enzyme polymorphism and colorectal cancer

doi:10.3748/wjg.v11.i3.331

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jan 21, 2005; 11(3): 331-335
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.331

Relationship between metabolic enzyme polymorphism and colorectal cancer

Kun Chen, Qin-Ting Jiang, Han-Qing He

Kun Chen, Qin-Ting Jiang, Han-Qing He, Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China

Author contributions: All authors contributed equally to the work.

Supported by the National Natural Science Foundation of China, No. 30170828

Correspondence to: Professor Kun Chen, Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China. ck@zju.edu.cn

Telephone: +86-571-87217190 Fax: +86-571-87217184

Received: February 14, 2004
Revised: February 18, 2004
Accepted: March 4, 2004
Published online: January 21, 2005

Abstract

AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.

METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.

RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).

CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion, NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.

Keywords: Colorectal cancer, Glutathione S-transferase T1, N-acetyltransferase, Polymorphism