Esophageal Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 15, 2004; 10(8): 1093-1097
Published online Apr 15, 2004. doi: 10.3748/wjg.v10.i8.1093
Loss of myeloid-related proteins 8 and myeloid-related proteins 14 expression in human esophageal squamous cell carcinoma correlates with poor differentiation
Jian-Ping Kong, Fang Ding, Chuan-Nong Zhou, Xiu-Qin Wang, Xiao-Ping Miao, Min Wu, Zhi-Hua Liu
Jian-Ping Kong, Fang Ding, Chuan-Nong Zhou, Xiu-Qin Wang, Min Wu, Zhi-Hua Liu, National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Xiao-Ping Miao, Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: All authors contributed equally to the work.
Supported by China Key Program on Basic Research, No.G1998051021, the Chinese Hi-tech R&D Program, No.2001AA231041, and National Science Foundation of China, No.30170519.
Correspondence to: Dr. Zhi-Hua Liu, National Laboratory of Molecular Oncology, Cancer Institute,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. liuzh@pubem.cicams.ac.cn
Telephone: +86-10-67723789 Fax: +86-10-67723789
Received: October 20, 2003
Revised: December 23, 2003
Accepted: January 12, 2004
Published online: April 15, 2004
Abstract

AIM: To study the expression of myeloid-related proteins (MRP)8 and myeloid-related proteins(MRP)14 in human esophageal squamous cell carcinoma and to investigate if there was any correlation between MRP8 and MRP14 expression level and histopathological grade in these tumors.

METHODS: In this study, 65 cases of advanced esophageal squamous cell carcinoma were assessed for MRP8 and MRP14 expression using immunohistochemistry. Statistical analysis was performed for the comparison of MRP8 and MRP14 expression in normal and tumor tissues, and their relationship with clinicopathological features.

RESULTS: Reduced or absent expression of MRP8 and MRP14 was observed in esophageal squamous cell carcinoma, with a significant difference between tumor tissues and normal tissues (P < 0.01 and P < 0.01 for MRP8 and MRP14, respectively). Poorly differentiated tumors presented a greater decrease than well and moderately differentiated tumors, with a correlation between their protein level and histopathological grading (P < 0.001 and P < 0.001, respectively). However, no significant association was found between MRP8 and MRP14 expression and age or gender (P > 0.05).

CONCLUSION: These findings suggest that the decreased expression of MRP8 and MRP14 might play an important role in the pathogenesis of human esophageal squamous cell carcinoma, being particularly associated with poor differentiation of tumor cells.

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