Induction of HSF1 expression is associated with sporadic colorectal cancer

doi:10.3748/wjg.v10.i21.3122

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Nov 1, 2004; 10(21): 3122-3126
Published online Nov 1, 2004. doi: 10.3748/wjg.v10.i21.3122

Induction of HSF1 expression is associated with sporadic colorectal cancer

Hui Cen, Shu Zheng, Yong-Ming Fang, Xiao-Ping Tang, Qi Dong

Hui Cen, Shu Zheng, Yong-Ming Fang, Qi Dong, Cancer Institute, The Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou 310009, Zhejiang Province, China

Hui Cen, Xiao-Ping Tang, Institute of Optic and Electronic Technologies, Chinese Academy of Sciences, Chengdu 610209, Sichuan Province, China

Author contributions: All authors contributed equally to the work.

Supported by 100 Scholars Plan of Chinese Academy of Sciences

Correspondence to: Shu Zheng, Cancer Institute, The Second Affiliated Hospital of Medical School, Zhejiang University, Hanzhou 310009, Zhejiang Province, China. zhengshu@zju.edu.cn

Received: June 21, 2003
Revised: July 24, 2003
Accepted: July 31, 2003
Published online: November 1, 2004

Abstract

AIM: To explore the activation of signal transduction pathways related with the carcinogenesis of sporadic colon cancers.

METHODS: A gene array monitoring the activation of 8 signal transduction pathways (PathwayFinder GEArray) was used to screen the differentially expressed genes between colorectal cancer and normal colon tissues. The differentially expressed genes were further analyzed by RT-PCR, using RNA derived from colorectal cancer and normal colon tissue of 35 patients.

RESULTS: The expression of HSF1, HSF27, HSP90 and iNOS was increased in colon cancer tissues compared to normal colon tissue using PathwayFinder GEArray. The RT-PCR results showed that the expression of HSF1 was increased in 86% (30/35) patients and the expression of iNOS was increased in 63% (22/35) patients.

CONCLUSION: The induction of HSF1 gene expression is associated with sporadic colon cancer. HSF1 induces heat shock stress signaling pathway, which might play a role in the carcinogenesis of sporadic colorectal cancer.

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