Relationship between serum calcium and CA 19-9 levels in colorectal cancer

doi:10.3748/wjg.v10.i13.1890

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Jul 1, 2004; 10(13): 1890-1892
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1890

Relationship between serum calcium and CA 19-9 levels in colorectal cancer

Peter Fuszek, Peter Lakatos, Adam Tabak, Janos Papp, Zsolt Nagy, Istvan Takacs, Henrik Csaba Horvath, Peter Laszlo Lakatos, Gabor Speer

Peter Fuszek, Peter Lakatos, Adam Tabak, Janos Papp, Zsolt Nagy, Istvan Takacs, Henrik Csaba Horvath, Peter Laszlo Lakatos, Gabor Speer, 1st Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

Author contributions: All authors contributed equally to the work.

Correspondence to: Peter Fuszek MD, 1st Department of Medicine, Faculty of Medicine, Semmelweis University, 1083 Budapest, Korányi S. u. 2/a, Hungary. fuszpet@bel1.sote.hu

Telephone: +36-20-9280-451

Received: February 20, 2004
Revised: March 6, 2004
Accepted: March 13, 2004
Published online: July 1, 2004

Abstract

AIM: To examine the calcium metabolism of colorectal cancer (CRC) in patients with colorectal cancer and control patients.

METHODS: Seventy newly diagnosed CRC patients were included. The healthy control group was age and gender matched (n = 32). Particular attention was devoted to the relationship between serum calcium of patients, and levels of AFP, CEA, carbohydrate antigen 19-9 (CA 19-9) (that could be considered as prognostic factors). Furthermore, the Ca-sensing receptor (CaSR) gene A986S polymorphism was investigated in these patients, as well as the relationship between different CaSR genotypes and the data stated above.

RESULTS: A lower level of ionized calcium (also corrected for albumin) was found in the serum of CRC patients with normal 25 (OH) vitamin D levels. The ionized calcium concentration was inversely correlated with the serum level of CA 19-9. There was no difference in the distribution of CaSR genotypes, between CRC patients and general population. The genotypes did not correlate with other data examined.

CONCLUSION: Based on these results, lower levels of serum calcium might be a pathogenic and prognostic factor in colorectal cancer.

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