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Cited by in CrossRef
For: Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. World J Gastroenterol 2012; 18(45): 6577-6586 [PMID: 23236232 DOI: 10.3748/wjg.v18.i45.6577]
URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6577.htm
Number Citing Articles
1
Magdalena K. Scheck, Ralf D. Hofheinz, Sylvie Lorenzen. HER2-Positive Gastric Cancer and Antibody Treatment: State of the Art and Future DevelopmentsCancers 2024; 16(7): 1336 doi: 10.3390/cancers16071336
2
Dong Won Baek, Byung Woog Kang, Jong Gwang Kim. The Predictive Value of Epstein-Barr Virus-Positivity in Patients Undergoing Gastrectomy Followed by Adjuvant ChemotherapyChonnam Medical Journal 2018; 54(3): 173 doi: 10.4068/cmj.2018.54.3.173
3
Li‑Jie Xia, Yan‑Ling Wu, Fu‑Chun Zhang. Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathwayOncology Letters 2017;  doi: 10.3892/ol.2017.7112
4
Ying Wang, You Lv, Te Si Liu, Wen Di Yan, Li Yan Chen, Zhu Hu Li, Ying Shi Piao, Ren Bo An, Zhen Hua Lin, Xiang Shan Ren. Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathwayLife Sciences 2019; 223: 110 doi: 10.1016/j.lfs.2019.03.025
5
Hugo Manuel Lopes de Sousa, Joana Patrícia Costa Ribeiro, Mafalda Basílio Timóteo. Epstein-Barr Virus - New TrendsInfectious Diseases 2021; 11 doi: 10.5772/intechopen.93649
6
Yi-wang Zhang, Dan He, Cui Tan, Min Dong, Lu Zhou, Chun-kui Shao. Differential expression of HER2 and downstream proteins in prediction of advanced tumor phenotypes and overall survival of patients with Epstein-Barr virus-positive vs. negative gastric cancersPathology - Research and Practice 2019; 215(11): 152675 doi: 10.1016/j.prp.2019.152675
7
Comprehensive molecular characterization of gastric adenocarcinomaNature 2014; 513(7517): 202 doi: 10.1038/nature13480
8
Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y. Lauwers, Do Youn Park. High-throughput Protein and mRNA Expression–based Classification of Gastric Cancers Can Identify Clinically Distinct Subtypes, Concordant With Recent Molecular ClassificationsAmerican Journal of Surgical Pathology 2017; 41(1): 106 doi: 10.1097/PAS.0000000000000756
9
Yi-wang Zhang, Xiao-xiao Zhao, Cui Tan, Zhi-gang Zhang, Ye Jiang, Jian-ning Chen, Hong-bo Wei, Ling Xue, Hai-gang Li, Hong Du, Chun-kui Shao. Epstein-Barr virus latent membrane protein 2A suppresses the expression of HER2 via a pathway involving TWIST and YB-1 in Epstein-Barr virus-associated gastric carcinomasOncotarget 2015; 6(1): 207 doi: 10.18632/oncotarget.2702
10
Xiaolin Peng, Yao Liu, Xin Peng, Zhengming Wang, Zhe Zhang, Yuling Qiu, Meihua Jin, Ran Wang, Dexin Kong. Clinical features and the molecular biomarkers of olfactory neuroblastomaPathology - Research and Practice 2018; 214(8): 1123 doi: 10.1016/j.prp.2018.06.002
11
Dong Won Baek, Byung Woog Kang, Soyoon Hwang, Jong Gwang Kim, An Na Seo, Han Ik Bae, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung, Wansik Yu. Clinical Significance of p53 Protein Expression, Beta-catenin Expression and HER2 Expression for Epstein-Barr Virus-associated Gastric CancerChonnam Medical Journal 2017; 53(2): 140 doi: 10.4068/cmj.2017.53.2.140
12
Tasuku Matsuoka, Masakazu Yashiro. The Role of PI3K/Akt/mTOR Signaling in Gastric CarcinomaCancers 2014; 6(3): 1441 doi: 10.3390/cancers6031441
13
Yongji Zeng, Ramon U. Jin. Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancerSeminars in Cancer Biology 2022; 86: 566 doi: 10.1016/j.semcancer.2021.12.004
14
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino, Yasuhisa Shinomura. <italic>IGF2</italic> differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesionsWorld Journal of Gastroenterology 2014; 20(29): 10050-10061 doi: 10.3748/wjg.v20.i29.10050
15
Daniela Lazar, Sorina Taban, Marioara Cornianu, Alexandra Faur, Ioan Romosan, Adrian Goldis. Gastric Cancer2017;  doi: 10.5772/intechopen.69737
16
Jin Wang, Xinye Shao, Yang Liu, Ruichuan Shi, Bowen Yang, Jiawen Xiao, Yunpeng Liu, Xiujuan Qu, Zhi Li. Mutations of key driver genes in gastric cancer metastasis risk: a systematic review and meta-analysisExpert Review of Molecular Diagnostics 2021; 21(9): 963 doi: 10.1080/14737159.2021.1946394
17
Xiaojuan Ren, Chao Feng, Yubo Wang, Pu Chen, Simeng Wang, Jianling Wang, Hongxin Cao, Yujun Li, Meiju Ji, Peng Hou. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathwaysExperimental & Molecular Medicine 2023; 55(8): 1757 doi: 10.1038/s12276-023-01062-5
18
Xinkui Liu, Jiarui Wu, Dan Zhang, Kaihuan Wang, Xiaojiao Duan, Ziqi Meng, Xiaomeng Zhang. Network Pharmacology-Based Approach to Investigate the Mechanisms ofHedyotis diffusaWilld. in the Treatment of Gastric CancerEvidence-Based Complementary and Alternative Medicine 2018; 2018: 1 doi: 10.1155/2018/7802639
19
Alireza Tabibzadeh, Fahimeh Safarnezhad Tameshkel, Yousef Moradi, Saber Soltani, Maziar Moradi-Lakeh, G. Hossein Ashrafi, Nima Motamed, Farhad Zamani, Seyed Abbas Motevalian, Mahshid Panahi, Maryam Esghaei, Hossein Ajdarkosh, Alireza Mousavi-Jarrahi, Mohammad Hadi Karbalaie Niya. Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysisScientific Reports 2020; 10(1) doi: 10.1038/s41598-020-73770-1
20
Diana Carli, Silvia Kalantari, Rosaria Manicone, Paola Coppo, Paola Francia di Celle, Roberta La Selva, Federica Santoro, Carlotta Ranieri, Simona Cardaropoli, Franca Fagioli, Giovanni Battista Ferrero, Nicoletta Resta, Alessandro Mussa. Kaposiform hemangioendothelioma further broadens the phenotype of PIK3CA‐related overgrowth spectrumClinical Genetics 2021; 100(5): 624 doi: 10.1111/cge.14047
21
Wen Kang, Xiao Zheng, Ping Wang, Shanyu Guo. Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitroInternational Journal of Molecular Medicine 2018;  doi: 10.3892/ijmm.2018.3532
22
Ziyu Ji, Jianlin Shen, Yujian Lan, Qian Yi, Huan Liu. Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studiesMedComm 2023; 4(4) doi: 10.1002/mco2.308
23
S&eacute;rgia Velho, Maria Sofia Fernandes, Marina Leite, Ceu Figueiredo, Raquel Seruca. Causes and consequences of microsatellite instability in gastric carcinogenesisWorld Journal of Gastroenterology 2014; 20(44): 16433-16442 doi: 10.3748/wjg.v20.i44.16433
24
Hadeel Kheraldine, Ishita Gupta, Farhan Sachal Cyprian, Semir Vranic, Halema F. Al-Farsi, Maysaloun Merhi, Said Dermime, Ala-Eddin Al Moustafa. Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathwaysCancer Cell International 2024; 24(1) doi: 10.1186/s12935-023-03195-z
25
Zhihao Zhang, Mengmeng Dou, Xiaofang Yao, Hao Tang, Zhubo Li, Xiaoyan Zhao. Potential Biomarkers in Diagnosis of Human Gastric CancerCancer Investigation 2016; 34(3): 115 doi: 10.3109/07357907.2015.1114122
26
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash. The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventionsEuropean Journal of Pharmacology 2021; 898: 173983 doi: 10.1016/j.ejphar.2021.173983
27
Euno Choi, Sun-ju Byeon, Soo Hee Kim, Hyun Ju Lee, Hyeong Ju Kwon, HyeSeong Ahn, Dong Ha Kim, Mee Soo Chang, Joseph S Pagano. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric CarcinomasPLOS ONE 2015; 10(7): e0130839 doi: 10.1371/journal.pone.0130839
28
Joana Ribeiro, Andreia Oliveira, Mariana Malta, Claudia Oliveira, Fernanda Silva, Ana Galaghar, Luís Pedro Afonso, Maria Cassiano Neves, Rui Medeiros, Pedro Pimentel-Nunes, Hugo Sousa. Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in PortugalWorld Journal of Gastroenterology 2017; 23(40): 7292-7302 doi: 10.3748/wjg.v23.i40.7292
29
Chiara Romano, Sandra Di Gregorio, Maria Stella Pennisi, Elena Tirrò, Giuseppe Broggi, Rosario Caltabiano, Livia Manzella, Martino Ruggieri, Paolo Vigneri, Antonio Di Cataldo. Multiple primary malignances managed with surgical excision: a case report with next generation sequencing analysisMolecular Biology Reports 2022; 49(9): 9059 doi: 10.1007/s11033-022-07630-8
30
Yu Sunakawa, Heinz-Josef Lenz. Molecular Classification of Gastric Adenocarcinoma: Translating New Insights from The Cancer Genome Atlas Research NetworkCurrent Treatment Options in Oncology 2015; 16(4) doi: 10.1007/s11864-015-0331-y
31
Xuechao Liu, Jianjun Liu, Haibo Qiu, Pengfei Kong, Shangxiang Chen, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Dazhi Xu, Xiaowei Sun. Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysisBMC Cancer 2015; 15(1) doi: 10.1186/s12885-015-1813-9
32
Dongmei Ji, Zhe Zhang, Lei Cheng, Jinjia Chang, Shanshan Wang, Biqiang Zheng, Rongliang Zheng, Zuojun Sun, Chenchen Wang, Zhiqing Zhang, Rujiao Liu, Xiaowei Zhang, Xin Liu, Xiaofeng Wang, Jin Li, Guillermo Velasco. The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death PathwayPLoS ONE 2014; 9(1): e85116 doi: 10.1371/journal.pone.0085116
33
Ying Zhang, Chang-Feng Li, Lian-Jun Ma, Meng Ding, Bin Zhang. MicroRNA-224 aggrevates tumor growth and progression by targeting mTOR in gastric cancerInternational Journal of Oncology 2016; 49(3): 1068 doi: 10.3892/ijo.2016.3581
34
Xiaobing Shen, Ying Zhao, Xiaowei Chen, Haixiang Sun, Mengqi Liu, Wenwen Zhang, Fei Jiang, Pengfei Li. Associations of PIK3CA mutations with clinical features and prognosis in gastric cancerFuture Oncology 2019; 15(16): 1873 doi: 10.2217/fon-2018-0335
35
Takamitsu Sasaki, Hiroki Kuniyasu, Yi Luo, Misaho Kitayoshi, Eriko Tanabe, Daisuke Kato, Satoshi Shinya, Kiyomu Fujii, Hitoshi Ohmori, Yuichi Yamashita. AKT Activation and Telomerase Reverse Transcriptase Expression are Concurrently Associated with Prognosis of Gastric CancerPathobiology 2014; 81(1): 36 doi: 10.1159/000351721
36
Gaetano Romano. The Role of the Dysfunctional Akt-Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug DevelopmentScientifica 2013; 2013: 1 doi: 10.1155/2013/317186
37
TAKAMITSU SASAKI, HIROKI KUNIYASU. Significance of AKT in gastric cancer (Review)International Journal of Oncology 2014; 45(6): 2187 doi: 10.3892/ijo.2014.2678
38
Matthew J. Olnes, Holly A. Martinson. Recent advances in immune therapies for gastric cancerCancer Gene Therapy 2021; 28(9): 924 doi: 10.1038/s41417-021-00310-y
39
Ji-Won Kim, Hye Seung Lee, Kyung Han Nam, Soyeon Ahn, Jin Won Kim, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Keun-Wook Lee. PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancerOncotarget 2017; 8(53): 90948 doi: 10.18632/oncotarget.18770
40
Vera Genitsch, Alexander Novotny, Christian A. Seiler, Dino Kröll, Axel Walch, Rupert Langer. Epstein–Barr Virus in Gastro-Esophageal Adenocarcinomas – Single Center Experiences in the Context of Current LiteratureFrontiers in Oncology 2015; 5 doi: 10.3389/fonc.2015.00073
41
AYA SHINOZAKI-USHIKU, AKIKO KUNITA, MASASHI FUKAYAMA. Update on Epstein-Barr virus and gastric cancer (Review)International Journal of Oncology 2015; 46(4): 1421 doi: 10.3892/ijo.2015.2856
42
TAKAMITSU SASAKI, YUICHI YAMASHITA, HIROKI KUNIYASU. AKT plays a crucial role in gastric cancerOncology Letters 2015; 10(2): 607 doi: 10.3892/ol.2015.3260
43
Mayo Hirabayashi, Damien Georges, Gary M. Clifford, Catherine de Martel. Estimating the Global Burden of Epstein-Barr Virus–Associated Gastric Cancer: A Systematic Review and Meta-AnalysisClinical Gastroenterology and Hepatology 2023; 21(4): 922 doi: 10.1016/j.cgh.2022.07.042
44
Pranshu Sahgal, Brandon M. Huffman, Deepa T. Patil, Walid K. Chatila, Rona Yaeger, James M. Cleary, Nilay S. Sethi. Early TP53 Alterations Shape Gastric and Esophageal Cancer DevelopmentCancers 2021; 13(23): 5915 doi: 10.3390/cancers13235915
45
Jung-Soo Pyo, Nae-Yu Kim, Dong-Wook Kang. Prognostic Implication of EBV Infection in Gastric Carcinomas: A Systematic Review and Meta-AnalysisMedicina 2023; 59(5): 834 doi: 10.3390/medicina59050834
46
Sarah B. Fisher, Kevin E. Fisher, Malcolm H. Squires, Sameer H. Patel, David A. Kooby, Bassel F. El‐Rayes, Kenneth Cardona, Maria C. Russell, Charles A. Staley, Alton B. Farris, Shishir K. Maithel. HER2 in resected gastric cancer: Is there prognostic value?Journal of Surgical Oncology 2014; 109(2): 61 doi: 10.1002/jso.23456
47
Fang Cao, Cong Zhang, Wei Han, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu, Qin Liu. p-Akt as a potential poor prognostic factor for gastric cancer: a systematic review and meta-analysisOncotarget 2017; 8(35): 59878 doi: 10.18632/oncotarget.17001
48
Qing-Hai Li, Ying-Zhao Wang, Jian Tu, Chu-Wei Liu, Yu-Jie Yuan, Run Lin, Wei-Ling He, Shi-Rong Cai, Yu-Long He, Jin-Ning Ye. Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistanceGastroenterology Report 2020; 8(3): 179 doi: 10.1093/gastro/goaa026
49
Hua Li, Shubo Chen, Hui Li, Jianxin Cui, Yunhe Gao, Dianchao Wu, Shangfeng Luan, Yan Qin, Tongshan Zhai, Dengxiang Liu, Zhibin Huo. Association between PIK3CA alteration and prognosis of gastric cancer patients: a meta-analysisOncotarget 2018; 9(7): 7651 doi: 10.18632/oncotarget.23871
50
Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng, Yihang Pan, Zhe-Sheng Chen, Yulong He. Signaling pathways and therapeutic interventions in gastric cancerSignal Transduction and Targeted Therapy 2022; 7(1) doi: 10.1038/s41392-022-01190-w
51
Joonhong Park, Han Mo Yoo, Woori Jang, Soyoung Shin, Myungshin Kim, Yonggoo Kim, Seung-Woo Lee, Jeong Goo Kim. Distribution of somatic mutations of cancer-related genes according to microsatellite instability status in Korean gastric cancerMedicine 2017; 96(25): e7224 doi: 10.1097/MD.0000000000007224
52
Antonio Pellino, Erika Riello, Floriana Nappo, Stefano Brignola, Sabina Murgioni, Selma Ahcene Djaballah, Sara Lonardi, Vittorina Zagonel, Massimo Rugge, Fotios Loupakis, Matteo Fassan. Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectivesWorld Journal of Gastroenterology 2019; 25(38): 5773-5788 doi: 10.3748/wjg.v25.i38.5773
53
Jing Shi, Yi-Ping Qu, Peng Hou. Pathogenetic mechanisms in gastric cancerWorld Journal of Gastroenterology 2014; 20(38): 13804-13819 doi: 10.3748/wjg.v20.i38.13804
54
Nick Baniak, Jenna-Lynn Senger, Shahid Ahmed, S. C. Kanthan, Rani Kanthan. Gastric biomarkers: a global reviewWorld Journal of Surgical Oncology 2016; 14(1) doi: 10.1186/s12957-016-0969-3
55
Małgorzata Skierucha, Anya NA Milne, G Johan A Offerhaus, Wojciech P Polkowski, Ryszard Maciejewski, Robert Sitarz. Molecular alterations in gastric cancer with special reference to the early-onset subtypeWorld Journal of Gastroenterology 2016; 22(8): 2460-2474 doi: 10.3748/wjg.v22.i8.2460
56
Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba. Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature reviewBMC Cancer 2016; 16(1) doi: 10.1186/s12885-016-2422-y
57
Hiroyuki Yamamoto, Kohzoh Imai. Microsatellite instability: an updateArchives of Toxicology 2015; 89(6): 899 doi: 10.1007/s00204-015-1474-0
58
Aldo Giudice, Giovanni D’Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D’Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella. Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric CarcinogenesisOxidative Medicine and Cellular Longevity 2016; 2016: 1 doi: 10.1155/2016/6021934
59
Yiseul Choi, Young San Ko, Jinju Park, Youngsun Choi, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Douk Ho Hwang, Woo Ho Kim, Byung Lan Lee. HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancerWorld Journal of Gastroenterology 2016; 22(41): 9141-9153 doi: 10.3748/wjg.v22.i41.9141
60
Adrian Murphy, Ronan J. Kelly. From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal CancerGastroenterology Research and Practice 2015; 2015: 1 doi: 10.1155/2015/896560
61
Assaf Moore, Elad Hikri, Tal Goshen-Lago, Tamar Barkan, Sara Morgenstern, Elena Brook, Annett Maderer, Wilfried Roth, Noa Gordon, Hanoch Kashtan, Baruch Brenner, Markus Moehler, Irit Ben Aharon. Young-onset gastric cancer and Epstein–Barr Virus (EBV) – a major player in the pathogenesis?BMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-6517-0