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For: Huang ZH, Li LH, Yang F, Wang JF. Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions. World J Gastroenterol 2007; 13(6): 950-954 [PMID: 17352030 DOI: 10.3748/wjg.v13.i6.950]
URL: https://www.wjgnet.com/1007-9327/full/v13/i6/950.htm
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Afsaneh Mojtabanezhad Shariatpanahi, Maryam Yassi, Mehdi Nouraie, Amirhossein Sahebkar, Fatemeh Varshoee Tabrizi, Mohammad Amin Kerachian, Osman El-Maarri. The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysisPLOS ONE 2018; 13(7): e0200735 doi: 10.1371/journal.pone.0200735
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James B Rawson, Bharati Bapat. Epigenetic biomarkers in colorectal cancer diagnosticsExpert Review of Molecular Diagnostics 2012; 12(5): 499 doi: 10.1586/erm.12.39
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Marc Tänzer, Magdalena Liebl, Michael Quante. Molecular biomarkers in esophageal, gastric, and colorectal adenocarcinomaPharmacology & Therapeutics 2013; 140(2): 133 doi: 10.1016/j.pharmthera.2013.06.005
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Xinyue Zhao. Review of Role of Epigenetics in Cancer Research2021 11th International Conference on Biomedical Engineering and Technology 2021; : 164 doi: 10.1145/3460238.3460263
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Chang Kyo Oh, Young-Seok Cho. Pathogenesis and biomarkers of colorectal cancer by epigenetic alterationIntestinal Research 2024; 22(2): 131 doi: 10.5217/ir.2023.00115
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TaeJeong Oh, Nayoung Kim, Youngho Moon, Myung Soon Kim, Benjamin D. Hoehn, Chan Hee Park, Tae Soo Kim, Nam Kyu Kim, Hyun Cheol Chung, Sungwhan An. Genome-Wide Identification and Validation of a Novel Methylation Biomarker, SDC2, for Blood-Based Detection of Colorectal CancerThe Journal of Molecular Diagnostics 2013; 15(4): 498 doi: 10.1016/j.jmoldx.2013.03.004
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R Mayor, L Casadomé, D Azuara, V Moreno, S J Clark, G Capellà, M A Peinado. Long-range epigenetic silencing at 2q14.2 affects most human colorectal cancers and may have application as a non-invasive biomarker of diseaseBritish Journal of Cancer 2009; 100(10): 1534 doi: 10.1038/sj.bjc.6605045
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Marjolaine A. Pelissier-Rota, Nicolas T. Chartier, Muriel R. Jacquier-Sarlin. Intercellular Communication in Cancer2015; : 53 doi: 10.1007/978-94-017-7380-5_4
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Dalma Müller, Balázs Győrffy. DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancerBiochimica et Biophysica Acta (BBA) - Reviews on Cancer 2022; 1877(3): 188722 doi: 10.1016/j.bbcan.2022.188722
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Yoon Dae Han, Tae Jeong Oh, Tae-Ha Chung, Hui Won Jang, Youn Nam Kim, Sungwhan An, Nam Kyu Kim. Early detection of colorectal cancer based on presence of methylated syndecan-2 (SDC2) in stool DNAClinical Epigenetics 2019; 11(1) doi: 10.1186/s13148-019-0642-0
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Su Man Lee, Jae Yong Park, Dong Sun Kim. Methylation of TMEFF2 Gene in Tissue and Serum DNA from Patients with Non-Small Cell Lung CancerMolecules and Cells 2012; 34(2): 171 doi: 10.1007/s10059-012-0083-5
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Dong Tang, Daorong Wang, Hongbo Li. Combination analysis of hypermethylated SFRP1 and SFRP2 gene in fecal as a novel epigenetic biomarker panel for colorectal cancer screeningJournal of Nanjing Medical University 2008; 22(2): 96 doi: 10.1016/S1007-4376(08)60020-9
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Stefan David, Stephen J. Meltzer. Pre-Invasive Disease: Pathogenesis and Clinical Management2011; : 41 doi: 10.1007/978-1-4419-6694-0_4
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Linda J.W. Bosch, Beatriz Carvalho, Remond J.A. Fijneman, Connie R. Jimenez, Herbert M. Pinedo, Manon van Engeland, Gerrit A. Meijer. Molecular Tests for Colorectal Cancer ScreeningClinical Colorectal Cancer 2011; 10(1): 8 doi: 10.3816/CCC.2011.n.002
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Yoshinaga Okugawa, William M. Grady, Ajay Goel. Epigenetic Alterations in Colorectal Cancer: Emerging BiomarkersGastroenterology 2015; 149(5): 1204 doi: 10.1053/j.gastro.2015.07.011
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Chang Woo Kim, Hyunjin Kim, Hyoung Rae Kim, Bong-Hyeon Kye, Hyung Jin Kim, Byung Soh Min, Tae Jeong Oh, Sungwhan An, Suk-Hwan Lee. Colorectal cancer screening using a stool DNA-based SDC2 methylation test: a multicenter, prospective trialBMC Gastroenterology 2021; 21(1) doi: 10.1186/s12876-021-01759-9
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Jürgen Veeck, Erik Noetzel, Nuran Bektas, Edgar Jost, Arndt Hartmann, Ruth Knüchel, Edgar Dahl. Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancerMolecular Cancer 2008; 7(1) doi: 10.1186/1476-4598-7-83
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Y. Koga, M. Yasunaga, Y. Moriya, T. Akasu, S. Fujita, S. Yamamoto, H. Baba, Y. Matsumura. Detection of the DNA Point Mutation of Colorectal Cancer Cells Isolated from Feces Stored Under Different ConditionsJapanese Journal of Clinical Oncology 2008; 39(1): 62 doi: 10.1093/jjco/hyn129
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Metin Sen, Oztürk Ozdemir, Mustafa Turan, Sema Arici, Fazilet Yildiz, Binnur Koksal, Fahrettin Goze. Epigenetic Inactivation of Tumor Suppressor SFRP2 and Point Mutation in KRAS Proto-Oncogene in Fistula - Associated Mucinous Type Anal Adenocarcinoma: Report of Two CasesInternal Medicine 2010; 49(15): 1637 doi: 10.2169/internalmedicine.49.3249
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Terje Ahlquist, Guro E Lind, Vera L Costa, Gunn I Meling, Morten Vatn, Geir S Hoff, Torleiv O Rognum, Rolf I Skotheim, Espen Thiis-Evensen, Ragnhild A Lothe. Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markersMolecular Cancer 2008; 7(1) doi: 10.1186/1476-4598-7-94
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S. Kristiansen, G. Sölétormos. Medical Epigenetics2016; : 459 doi: 10.1016/B978-0-12-803239-8.00025-9
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M Alizade Naini, P Mokarram, S Kavousipour, N Zare, A Atapour, M Hassan Zarin, G Mehrabani, M Borji. Sensitive and Noninvasive Detection of Aberrant SFRP2 and MGMT-B Methylation in Iranian Patients with Colon PolypsAsian Pacific Journal of Cancer Prevention 2016; 17(4): 2185 doi: 10.7314/APJCP.2016.17.4.2185
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G.L. Wiesner, T.P. Slavin, J.S. Barnholtz-Sloan. Essentials of Genomic and Personalized Medicine2010; : 457 doi: 10.1016/B978-0-12-374934-5.00036-2
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Ashley G. Rivenbark, William B. Coleman. Toxicology and Epigenetics2012; : 317 doi: 10.1002/9781118349045.ch16
25
Dao-Rong Wang, Dong Tang. Hypermethylated <italic>SFRP2</italic> gene in fecal DNA is a high potential biomarker for colorectal cancer noninvasive screeningWorld Journal of Gastroenterology 2008; 14(4): 524-531 doi: 10.3748/wjg.14.524
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Qihua Yang, Tao Huang, Guoliang Ye, Bojun Wang, Xinjun Zhang. Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysisScientific Reports 2016; 6(1) doi: 10.1038/srep33339
27
Saeid Ghavami, Mozhdeh Zamani, Mazaher Ahmadi, Mehran Erfani, Sanaz Dastghaib, Mahsa Darbandi, Sara Darbandi, Omid Vakili, Morvarid Siri, Beniamin Oskar Grabarek, Dariusz Boroń, Maryam Zarghooni, Emilia Wiechec, Pooneh Mokarram. Epigenetic regulation of autophagy in gastrointestinal cancersBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2022; 1868(11): 166512 doi: 10.1016/j.bbadis.2022.166512
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Jingxin Ye, Jianfeng Zhang, Weifeng Ding. DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicineExploration of Targeted Anti-tumor Therapy 2024; 5(1): 34 doi: 10.37349/etat.2024.00203
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Andreas Herbst, Frank T. Kolligs. Detection of DNA hypermethylation in remote media of patients with colorectal cancer: new biomarkers for colorectal carcinomaTumor Biology 2012; 33(2): 297 doi: 10.1007/s13277-012-0346-y
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Micaela Freitas, Fábio Ferreira, Sónia Carvalho, Fernanda Silva, Paula Lopes, Luís Antunes, Sofia Salta, Francisca Diniz, Lúcio Lara Santos, José Flávio Videira, Rui Henrique, Carmen Jerónimo. A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathwayJournal of Translational Medicine 2018; 16(1) doi: 10.1186/s12967-018-1415-9
31
Chengguang Sui, Jianzhong Ma, Qun Chen, Yang Yang. The variation trends of SFRP2 methylation of tissue, feces, and blood detection in colorectal cancer developmentEuropean Journal of Cancer Prevention 2016; 25(4): 288 doi: 10.1097/CEJ.0000000000000185
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S. L. Rasmussen, H. B. Krarup, K. G. Sunesen, I. S. Pedersen, P. H. Madsen, O. Thorlacius‐Ussing. Hypermethylated DNA as a biomarker for colorectal cancer: a systematic reviewColorectal Disease 2016; 18(6): 549 doi: 10.1111/codi.13336
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Ping-ping Wu, Ji-hong Zou, Ri-ning Tang, Yao Yao, Cheng-zhong You. Detection and clinical significance of DLC1 gene methylation in serum DNA from colorectal cancer patientsChinese Journal of Cancer Research 2011; 23(4): 283 doi: 10.1007/s11670-011-0283-0
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Chengguang Sui, Guang Wang, Qun Chen, Jianzhong Ma. Variation risks of SFRP2 hypermethylation between precancerous disease and colorectal cancerTumor Biology 2014; 35(10): 10457 doi: 10.1007/s13277-014-2313-2
35
Maartje Massen, Kim Lommen, Kim A. D. Wouters, Johan Vandersmissen, Wim van Criekinge, James G. Herman, Veerle Melotte, Leo J. Schouten, Manon van Engeland, Kim M. Smits. Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkersClinical Epigenetics 2022; 14(1) doi: 10.1186/s13148-022-01273-z
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Linda J.W. Bosch, Frank A. Oort, Maarten Neerincx, Carolina A.J. Khalid-de Bakker, Jochim S. Terhaar sive Droste, Veerle Melotte, Daisy M.A.E. Jonkers, Ad A.M. Masclee, Sandra Mongera, Madeleine Grooteclaes, Joost Louwagie, Wim van Criekinge, Veerle M.H. Coupé, Chris J. Mulder, Manon van Engeland, Beatriz Carvalho, Gerrit A. Meijer. DNA Methylation of Phosphatase and Actin Regulator 3 Detects Colorectal Cancer in Stool and Complements FITCancer Prevention Research 2012; 5(3): 464 doi: 10.1158/1940-6207.CAPR-11-0315
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Khatere Mokhtari, Maryam Peymani, Mohsen Rashidi, Kiavash Hushmandi, Kamran Ghaedi, Afshin Taheriazam, Mehrdad Hashemi. Colon cancer transcriptomeProgress in Biophysics and Molecular Biology 2023; : 49 doi: 10.1016/j.pbiomolbio.2023.04.002
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Tae Jeong Oh, Hyun Il Oh, Yang Yei Seo, Dongjun Jeong, Changjin Kim, Hyoun Woo Kang, Yoon Dae Han, Hyun Cheol Chung, Nam Kyu Kim, Sungwhan An. Feasibility of quantifying SDC2 methylation in stool DNA for early detection of colorectal cancerClinical Epigenetics 2017; 9(1) doi: 10.1186/s13148-017-0426-3
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Ningning Zhao, Chuanxi Lai, Yunfei Wang, Sheng Dai, Hongcang Gu. Understanding the role of DNA methylation in colorectal cancer: Mechanisms, detection, and clinical significanceBiochimica et Biophysica Acta (BBA) - Reviews on Cancer 2024; 1879(3): 189096 doi: 10.1016/j.bbcan.2024.189096
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Aitor Rodriguez-Casanova, Nicolás Costa-Fraga, Aida Bao-Caamano, Rafael López-López, Laura Muinelo-Romay, Angel Diaz-Lagares. Epigenetic Landscape of Liquid Biopsy in Colorectal CancerFrontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.622459
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C. Kurkjian, S. Kummar, A.J. Murgo. DNA Methylation: Its Role in Cancer Development and TherapyCurrent Problems in Cancer 2008; 32(5): 187 doi: 10.1016/j.currproblcancer.2008.08.002
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Jürgen Veeck, Peter J Wild, Thomas Fuchs, Peter J Schüffler, Arndt Hartmann, Ruth Knüchel, Edgar Dahl. Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancerBMC Cancer 2009; 9(1) doi: 10.1186/1471-2407-9-217
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Witold Kycler, Bronisława Szarzyńska, Cezary Łoziński, Konstanty Korski, Katarzyna Lamperska. Analysis of O6-methylguanine-DNA methyltransferase methylation status in sporadic colon polypsReports of Practical Oncology & Radiotherapy 2012; 17(1): 13 doi: 10.1016/j.rpor.2011.11.002
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Yaping Cao, Guodong Zhao, Mufa Yuan, Xiaoyu Liu, Yong Ma, Yang Cao, Bei Miao, Shuyan Zhao, Danning Li, Shangmin Xiong, Minxue Zheng, Sujuan Fei. KCNQ5 and C9orf50 Methylation in Stool DNA for Early Detection of Colorectal CancerFrontiers in Oncology 2021; 10 doi: 10.3389/fonc.2020.621295
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Leonie van Dam, Ernst J. Kuipers, Monique E. van Leerdam. Performance improvements of stool-based screening testsBest Practice & Research Clinical Gastroenterology 2010; 24(4): 479 doi: 10.1016/j.bpg.2010.03.009
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Pooneh Mokarram, Nazanin Zare, Hamed Jafari, Soudabeh Kavousi Pour, Mahdi Barazesh, Mahvash Alizade Naini. The Methylation Status of MGMT and SFRP2 Genes in Iranian Patients With PolypsThrita 2015; 4(2) doi: 10.5812/thrita.28601v2
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Hu Zhang, Jian Qi, Ya-Qiong Wu, Ping Zhang, Jun Jiang, Qi-Xian Wang, You-Qing Zhu. Accuracy of early detection of colorectal tumours by stool methylation markers: A meta-analysisWorld Journal of Gastroenterology 2014; 20(38): 14040-14050 doi: 10.3748/wjg.v20.i38.14040
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Meng Xue, San Chuan Lai, Zhi Peng Xu, Liang Jing Wang. Noninvasive DNA methylation biomarkers in colorectal cancer: A systematic reviewJournal of Digestive Diseases 2015; 16(12): 699 doi: 10.1111/1751-2980.12299
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Rong-Lin Zhai, Fei Xu, Pei Zhang, Wan-Li Zhang, Hui Wang, Ji-Liang Wang, Kai-Lin Cai, Yue-Ping Long, Xiao-Ming Lu, Kai-Xiong Tao, Guo-Bin Wang. The Diagnostic Performance of Stool DNA Testing for Colorectal CancerMedicine 2016; 95(5): e2129 doi: 10.1097/MD.0000000000002129
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CHUN-GANG HE, QIN-YUAN HUANG, LI-SHENG CHEN, ZHI-AN LING, HONG-GEN WU, HONG-QIANG DENG. p33ING1b methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesionsOncology Letters 2014; 7(5): 1639 doi: 10.3892/ol.2014.1923
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Ashley G Rivenbark, William B Coleman. Practical applications for epigenetic biomarkers in cancer diagnosticsExpert Opinion on Medical Diagnostics 2007; 1(1): 17 doi: 10.1517/17530059.1.1.17
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Jun Yu, Yang Xie, Mengying Li, Fenfang Zhou, Zhenyang Zhong, Yuting Liu, Feng Wang, Jian Qi. Association between SFRP promoter hypermethylation and different types of cancer: A systematic review and meta‑analysisOncology Letters 2019;  doi: 10.3892/ol.2019.10709
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Erica Lana, Marie-Elisabeth Brun, Isabelle Rivals, Janick Selves, Sylvain Kirzin, Andriy Lutsyk, Vasily Gordiyuk, Frédéric Bibeau, Alla Rynditch, Albertina De Sario. BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced AdenomasCancers 2009; 1(1): 3 doi: 10.3390/cancers1010003
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Eivor Alette Laugsand, Siv Sellæg Brenne, Frank Skorpen. DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samplesInternational Journal of Colorectal Disease 2021; 36(2): 239 doi: 10.1007/s00384-020-03757-x
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Ulrike Haug, Moritz N Wente, Christoph M Seiler, Ralf Jesnowski, Hermann Brenner. Stool testing for the early detection of pancreatic cancer: rationale and current evidenceExpert Review of Molecular Diagnostics 2008; 8(6): 753 doi: 10.1586/14737159.8.6.753
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Feng Chen, Lijuan Pei, Siyao Liu, Yan Lin, Xinyin Han, Erhong Meng, Xintong Wang, Shuai Hong, Dongliang Wang, Feide Liu, Yang Fei, Guangda Wang. Identification of a Novel Immune-Related CpG Methylation Signature to Predict Prognosis in Stage II/III Colorectal CancerFrontiers in Genetics 2021; 12 doi: 10.3389/fgene.2021.684349
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Nayeralsadat Fatemi, Sascha Tierling, Hamidreza Aboulkheyr Es, Maryam Varkiani, Ehsan Nazemalhosseini Mojarad, Hamid Asadzadeh Aghdaei, Jörn Walter, Mehdi Totonchi. DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicineInternational Journal of Cancer 2022; 151(12): 2068 doi: 10.1002/ijc.34186
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Rongbin Liu, Xuan Su, Yakang Long, Dalei Zhou, Xiao Zhang, Zulu Ye, Jiangjun Ma, Tao Tang, Fang Wang, Caiyun He. A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenomaMutation Research/Reviews in Mutation Research 2019; 779: 45 doi: 10.1016/j.mrrev.2019.01.003
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Keigo Yokoi, Keishi Yamashita, Masahiko Watanabe. Analysis of DNA Methylation Status in Bodily Fluids for Early Detection of CancerInternational Journal of Molecular Sciences 2017; 18(4): 735 doi: 10.3390/ijms18040735
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Mahir Gachabayov, Edward Lebovics, Aram Rojas, Daniel M Felsenreich, Rifat Latifi, Roberto Bergamaschi. Performance evaluation of stool DNA methylation tests in colorectal cancer screening: a systematic review and meta‐analysisColorectal Disease 2021; 23(5): 1030 doi: 10.1111/codi.15521
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Lixing Wang, Yu Liu, Duohan Zhang, Xiaoliang Xiong, Tingting Hao, Lili Zhong, Yinlong Zhao. Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening: a meta-analysisBMC Gastroenterology 2022; 22(1) doi: 10.1186/s12876-022-02395-7
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Giles O. Elliott, Ian T. Johnson, Jane Scarll, Jack Dainty, Elizabeth A. Williams, D. Garg, Amanda Coupe, David M. Bradburn, John C. Mathers, Nigel J. Belshaw. Quantitative profiling of CpG island methylation in human stool for colorectal cancer detectionInternational Journal of Colorectal Disease 2013; 28(1): 35 doi: 10.1007/s00384-012-1532-5
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K. F. Newton, W. Newman, J. Hill. Review of biomarkers in colorectal cancerColorectal Disease 2012; 14(1): 3 doi: 10.1111/j.1463-1318.2010.02439.x
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Y.-X. Luo, D.-K. Chen, S.-X. Song, L. Wang, J.-P. Wang. Aberrant methylation of genes in stool samples as diagnostic biomarkers for colorectal cancer or adenomas: A meta-analysisInternational Journal of Clinical Practice 2011; 65(12): 1313 doi: 10.1111/j.1742-1241.2011.02800.x
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Farid E. Ahmed, Mostafa M. Gouda, Nancy C. Ahmed, Yicheng Long. Use of Microfluidic Assays to Develop Reliable and Economic Nucleic Acid Application Technologies, Employing MicroRNAs for the Diagnostic Screening of Colon Cancer in Human Stool in Low-Resource SettingsInternational Journal of Nutrition 2020; 6(1): 44 doi: 10.14302/issn.2379-7835.ijn-20-3418
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Steven H. Itzkowitz. Stool DNA Testing for Colorectal Cancer: Development and AdvancesIntestinal Research 2012; 10(2): 134 doi: 10.5217/ir.2012.10.2.134
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Farid E. Ahmed, Mostafa M. Gouda, Nancy C. Ahmed, Murat Kara. Use of Microfluidic Assays to Develop Reliable and Economic Nucleic Acid Application Technologies, Employing MicroRNAs for the Diagnostic Screening of Colon Cancer in Human Stool in Low-Resource SettingsInternational Journal of Nutrition 2020; 5(4): 1 doi: 10.14302/issn.2379-7835.ijn-19-3123
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Satoshi Nagata, Tomofumi Hamada, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Yuji Kanmura, Masahiro Nomura, Yoshiaki Kamikawa, Suguru Yonezawa, Kazumasa Sugihara. Aberrant DNA methylation of tumor‐related genes in oral rinseCancer 2012; 118(17): 4298 doi: 10.1002/cncr.27417
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Qing Cao, Ye Tian, Zhiyi Deng, Fangfang Yang, Erfei Chen. Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic ImplicationsInternational Journal of Molecular Sciences 2024; 25(6): 3358 doi: 10.3390/ijms25063358
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Jennifer Ng, Jun Yu. Promoter Hypermethylation of Tumour Suppressor Genes as Potential Biomarkers in Colorectal CancerInternational Journal of Molecular Sciences 2015; 16(2): 2472 doi: 10.3390/ijms16022472
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Gerhard Jung, Eva Hernández-Illán, Leticia Moreira, Francesc Balaguer, Ajay Goel. Epigenetics of colorectal cancer: biomarker and therapeutic potentialNature Reviews Gastroenterology & Hepatology 2020; 17(2): 111 doi: 10.1038/s41575-019-0230-y
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G.L. Wiesner, T.P. Slavin, J.S. Barnholtz-Sloan. Genomic and Personalized Medicine2009; : 879 doi: 10.1016/B978-0-12-369420-1.00073-1
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Barbara Kinga Barták, Alexandra Kalmár, Bálint Péterfia, Árpád V. Patai, Orsolya Galamb, Gábor Valcz, Sándor Spisák, Barnabás Wichmann, Zsófia Brigitta Nagy, Kinga Tóth, Zsolt Tulassay, Péter Igaz, Béla Molnár. Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samplesEpigenetics 2017; 12(9): 751 doi: 10.1080/15592294.2017.1356957