Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Apr 28, 2020; 8(2): 98-108
Published online Apr 28, 2020. doi: 10.13105/wjma.v8.i2.98
Treatment strategies and preventive methods for drug-resistant Helicobacter pylori infection
Ru-Jia Li, Yuan-Yuan Dai, Chun Qin, Xiao-Hua Li, Yan-Chun Qin, Yong Pan, Yong-Yi Huang, Zan-Song Huang, Yan-Qiang Huang
Ru-Jia Li, Yuan-Yuan Dai, Chun Qin, Xiao-Hua Li, Yan-Chun Qin, Yong Pan, Yong-Yi Huang, Zan-Song Huang, Yan-Qiang Huang, Research Center for Prevention and Treatment of Drug Resistant Microbial Infections, Youjiang Medical University for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China
Author contributions: Li RJ searched the literature and wrote the first draft; Dai YY, Qin C, Li XH, Qin YC, Pan Y, Huang YY, and Huang ZS revised the manuscript; Huang YQ revised and finalized the manuscript.
Supported by National Natural Science Foundation of China, No. 81760739 and No. 31460023.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Qiang Huang, MD, PhD, Professor, Research Center for Prevention and Treatment of Drug Resistant Microbial Infections, Youjiang Medical University for Nationalities, No. 98, Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com
Received: December 26, 2019
Peer-review started: December 26, 2019
First decision: January 19, 2020
Revised: March 17, 2020
Accepted: March 19, 2020
Article in press: March 19, 2020
Published online: April 28, 2020
Core Tip

Core tip: The resistance rate of Helicobacter pylori is increasing and there is an urgent need to develop better treatment strategies. We review the current progress in the field with regard to prevention of drug-resistant bacterial infection, effective diagnosis and standardized treatment, rational application of antibacterial drugs, and prevention of drug-resistant bacterial transmission. The factors causing drug resistance are suggested to be eliminated so as to ensure the success of the first-line treatment of patients with drug resistance, whose accurate treatment is based on individual drug history and drug-sensitivity testing results. Traditional Chinese medicine has good effects in the treatment of drug-resistant bacterial infection and should be more widely applied.