Zhou Y, Zhou HC, Peng H, Zhang ZH. Primary small cell neuroendocrine carcinoma of the right posterior tongue. World J Meta-Anal 2020; 8(4): 285-291 [DOI: 10.13105/wjma.v8.i4.285]
Corresponding Author of This Article
Zhi-Hong Zhang, MD, Chairman, Chief Doctor, Professor, Surgeon, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. ghoahfoi@sina.com
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yu Zhou, Hui Peng, Zhi-Hong Zhang, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Hang-Cheng Zhou, Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Author contributions: Zhou Y performed the majority of the writing and prepared the figures and tables; Zhou H-C provided pathological technical support; Peng H performed the writing, review and editing of the manuscript; Zhang Z-H designed the outline and coordinated the writing of the paper; all authors have read and approve the final manuscript.
Conflict-of-interest statement: We have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhi-Hong Zhang, MD, Chairman, Chief Doctor, Professor, Surgeon, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. ghoahfoi@sina.com
Received: March 11, 2020 Peer-review started: March 11, 2020 First decision: June 18, 2020 Revised: July 30, 2020 Accepted: August 22, 2020 Article in press: August 22, 2020 Published online: August 28, 2020
Abstract
Small cell neuroendocrine carcinoma (SNEC) is an extremely aggressive tumor and mainly occurs in the lung. Primary extra-pulmonary SNEC is rare. To date, only 11 primary SNECs occurring in the oral cavity have been reported in the English literature. We describe a case of primary SNEC of the right posterior tongue in a 46-year-old man. The patient had stage IVA disease and received adjuvant chemotherapy, followed by radical surgery and radiotherapy. He remained tumor-free for 20 mo before death due to gastrointestinal metastasis. The relevant literature on the 11 previously reported patients was reviewed, and the clinical features, histopathological characteristics, differential diagnosis and therapeutic strategies of this rare tumor were analyzed.
Core Tip: Primary extra-pulmonary small cell neuroendocrine carcinoma (SNEC) is extremely rare. There are only 11 primary SNECs occurring in the oral cavity reported in the English literature. This time, we describe a case of primary SNEC of the right posterior tongue in a 46-year-old man. The treatment of this patient is described in detail. The relevant literature of the 11 previously reported patients was reviewed, and the clinical features, histopathological characteristics, differential diagnosis and therapeutic strategies of this rare tumor were analyzed.
