Risk factors for long-term prognosis of hepatocellular carcinoma patients after anatomic hepatectomy

Table 1 Baseline characteristics of study participants (n = 74)

Category	Numbers of patients	1 (yr)		3 (yr)
		χ2	P	χ2	P
Age, yr		0.732	0.694	0.56	0.756
≤ 60	42
> 60	32
Sex		0.037	0.848	0.352	0.553
Male	54
Female	20
Diabetes		0.073	0.788	3.044	0.081
Yes	12
No	62
Hypertension		0.021	0.883	0.099	0.754
Yes	23
No	51
Hepatic cirrhosis		3.653	0.056	8.864	0.003
Yes	33
No	41
Jaundice		10.610	0.001	12.118	0.0001
Yes	18
No	56
Portal vein tumor thrombus		1.602	0.206	0.749	0.387
Yes	7
No	67
Maximal tumor diameter, cm		8.325	0.004	5.111	0.024
≤ 5	41
> 5	33
Tumor number		1.754	0.185	0.134	0.715
Single	58
At least two	16
Tumor stage		22.402	0.0001	25.982	0.0001
1	30
2	15
3	14
4	15
BCLC stage		0.265	0.607	0.125	0.724
0	51
A	23
Alpha-fetoprotein, ng/mL		0.412	0.521	0.035	0.851
≤ 400	62
> 400	12
Albumin, g		0.053	0.818	1.004	0.316
≤ 35	8
> 35	66
AST, U/L		0.487	0.485	0.868	0.351
≤ 80	67
> 80	7

BCLC: Barcelona clinic liver cancer; AST: Aspartate aminotransferase.

Table 2 Univariate analyses of intraoperative and postoperative factors associated with 1-year and 3-year recurrence-free survival of hepatocellular carcinoma patients

Category	Number of patients	1 (yr)		3 (yr)
		χ2	P	χ2	P
Operation duration, h		0.026	0.873	0.045	0.832
≤ 3	6
3-5	17
> 5	51
Hepatic occlusion duration, min		0.368	0.544	0.007	0.932
≤ 30	41
> 30	33
Central venous pressure, mmHg		1.335	0.248	0.089	0.765
< 5	37
≥ 5	37
Hypotension		5.479	0.019	4.963	0.026
Yes	47
No	27
Hypotension frequency		3.855	0.050	3.490	0.062
≤ 3	44
> 3	30
Hypotension duration, min		3.342	0.068	2.134	0.144
≤ 30	38
> 30	36
Blood loss, mL		6.943	0.008	12.287	0.002
< 800	56
≥ 800	18
Fluid infusion, mL		11.453	0.022	9.936	0.042
≤ 1500	3
1500-3000	36
3000-4500	20
4500-6000	7
> 6000	8
Blood transfusion		3.888	0.049	4.275	0.039
Yes	24
No	50
Vasoactive drugs		0.089	0.766	0.049	0.824
Yes	13
No	61
Postoperative infection		4.322	0.038	4.224	0.040
Yes	29
No	45
Adjuvant therapy		3.204	0.202	1.654	0.437
None	64
Chemotherapy	7
Radiotherapy	3

Table 3 Multivariate analyses of the intraoperative and postoperative factors associated with 3-year recurrence-free survival of hepatocellular carcinoma patients

Category	Multivariate
	B	SE	χ2	df	P value	Exp (B)	95%CI
Hepatic cirrhosis	-1.071	0.525	4.165	1	0.041	0.343	0.123-0.958
Tumor stage	0.639	0.178	12.842	1	0.001	1.894	1.336-2.687
Hypotension	0.905	0.477	3.607	1	0.050	2.472	0.971-6.292
Blood loss	0.904	0.448	4.069	1	0.044	2.469	1.026-5.944

B: Regression coefficient; SE: Standard error; df: Degree of freedom; Exp (B): Ratio; CI: Confidence interval.