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©The Author(s) 2025.
World J Clin Cases. Jul 26, 2025; 13(21): 103841
Published online Jul 26, 2025. doi: 10.12998/wjcc.v13.i21.103841
Published online Jul 26, 2025. doi: 10.12998/wjcc.v13.i21.103841
Table 1 Comparison of clinicopathological features and immunohistochemical expression of endometrioid endometrial carcinoma between the two groups, n (%)
| MELF EEC (n = 60) | No MELF EEC (n = 145) | P value | |
| Age | 0.002 | ||
| ≤ 50 | 9 (15) | 52 (35.86) | |
| > 50 | 51 (85) | 93 (64.14) | |
| Tumor size | 0.000 | ||
| ≤ 2 cm | 10 (16.67) | 67 (46.21) | |
| > 2 cm | 50 (83.33) | 78 (53.79) | |
| Tumor grade | |||
| 1 | 22 (36.67) | 89 (61.38) | 0.000 |
| 2 | 36 (60.00) | 39 (26.90) | |
| 3 | 2 (3.33) | 17 (11.72) | |
| 2023 FIGO staging | |||
| I | 33 (55.00) | 105 (72.41) | 0.011 |
| II | 16 (26.67) | 29 (20.00) | |
| III | 11 (18.33) | 8 (5.52) | |
| IV | 0 (0) | 3 (2.07) | |
| Myometrial invasion | 0.020 | ||
| < 1/2 | 33 (55.00) | 104 (71.72) | |
| ≥ 1/2 | 27 (45.00) | 41 (28.28) | |
| Cervical stromal involvement | |||
| Negative | 49 (81.67) | 127 (87.59) | 0.278 |
| Positive | 11 (18.33) | 18 (12.41) | |
| LNM | |||
| Negative | 47 (78.33) | 138 (95.17) | 0.000 |
| Positive | 13 (21.67) | 7 (4.83) | |
| Micrometastasis | 7 | 1 | |
| Macrometastasis | 6 | 6 | |
| LVSI | |||
| Absent | 31 (51.67) | 125 (91.04) | 0.000 |
| Present | 29 (48.33) | 20 (8.96) | |
| < 5/slice | 18 (30.00) | 14 (9.66) | |
| ≥ 5/slice | 11 (18.33) | 6 (4.14) | |
| ER | 0.988 | ||
| ≤ 50% | 22 (36.67) | 53 (36.55) | |
| > 50% | 38 (63.33) | 92 (63.45) | |
| PR | 0.204 | ||
| ≤ 50% | 18 (30.00) | 57 (39.31) | |
| > 50% | 42 (70.00) | 88 (60.69) | |
| CXCR4 | / | ||
| Negative | 0 | 145 (100.00) | |
| Positive | 60 (100.00) | 0 |
Table 2 Comparison of immunohistochemical expression in different regions of endometrioid endometrial carcinoma with microcystic, elongated, and fragmented infiltration, n (%)
| Cases | High expression of CXCR4 | High expression of ER | High expression of PR | |
| EEC main area | 60 | 11 (18.33) | 38 (63.33) | 42 (70.00) |
| MELF invasion area | 60 | 49 (81.67) | 22 (36.67) | 18 (30.00) |
| P value | 0.000 | 0.000 |
- Citation: Wang JX, Shen DH, Zhang XB. CXCR4 expression and clinicopathological features of endometrial endometrioid carcinoma with the microcystic, elongated, and fragmented pattern. World J Clin Cases 2025; 13(21): 103841
- URL: https://www.wjgnet.com/2307-8960/full/v13/i21/103841.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v13.i21.103841