Breast non-mass-like lesions on contrast-enhanced ultrasonography: Feature analysis, breast image reporting and data system classification assessment

Figure 1 Fifty-three-year-old woman with a non-mass lesion in her left breast. A: Grayscale ultrasound image revealing a non-ductal non-mass-like lesion pattern without microcalcification. The original Breast Imaging Reporting and Data System (BI-RADS) category is 4a; B: On contrast-enhanced ultrasonography, the lesion exhibited synchronous enhancement without scope expansion. According to our readjusted BI-RADS method, the BI-RADS category of this lesion was reduced to three categories. The final pathology was adenosis.

Figure 2 Forty-five-year-old woman with a non-mass lesion in her right breast. A: Grayscale ultrasound image revealing a non-ductal non-mass-like lesion pattern without microcalcification. The original Breast Imaging Reporting and Data System (BI-RADS) category is 4a; B: On contrast-enhanced ultrasonography, the lesion exhibited hyper-enhancement without scope expansion. According to our readjusted BI-RADS method, the BI-RADS category of this lesion remained BI-RADS 4a. The final pathology was sclerosing adenosis.

Figure 3 Fifty-two-year-old woman with a non-mass lesion in her right breast. A: Grayscale ultrasound image revealing a ductal non-mass-like lesion pattern without microcalcification. The original Breast Imaging Reporting and Data System (BI-RADS) category is 4b; B: On contrast-enhanced ultrasonography, the lesion exhibited hyper-enhancement and scope expansion. According to our readjusted BI-RADS method, the BI-RADS category of this lesion remained BI-RADS 4c. The final pathology was intraductal carcinoma in situ.

Figure 4 Receiver-operating characteristic curves for ultrasonography, ultrasonography + contrast-enhanced ultrasound, and contrast-enhanced ultrasound + Breast Imaging Reporting and Data System. The area under the curve was 0.752 for ultrasonography, 0.877 for ultrasonography + contrast-enhanced ultrasound, and 0.903 for contrast-enhanced ultrasound + Breast Imaging Reporting and Data System. US: Ultrasonography; CEUS: Contrast-enhanced ultrasound; BI-RADS: Breast Imaging Reporting and Data System.