Sofosbuvir/Ribavirin therapy for patients experiencing failure of ombitasvir/paritaprevir/ritonavir + ribavirin therapy: Two cases report and review of literature

Figure 1 Ultrasonography findings of the right ulnar intercarpal joints in patient 2. A: Power Doppler imaging. There were clear synovial blood flow signals (arrows) with localization of the synovial thickening; B: B-mode imaging. Synovial thickening was observed as a low echoic lesion (surrounded by arrowheads).

Figure 2 Clinical course of patient 1 and patient 2. The serum hepatitis C virus RNA levels rapidly decreased and became undetectable in both of the cases. Both of the cases achieved a sustained virological response at 12 wk after the treatment. In Patient 2, the serum alanine aminotransferase (ALT) level transiently increased during the combination therapy with sofosbuvir and ribavirin. In Patient 2, the serum ALT levels decreased compared to the pretreatment levels after the start of the combination therapy. HCV: Hepatitis C virus; ALT: Alanine aminotransferase; SOF/RBV: Sofosbuvir and ribavirin; OBV/PTV/r+RBV: ombitasvir/paritaprevir/ritonavir plus ribavirin.