Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature

Figure 1 Pathological analysis of the surgical specimen (hematoxylin and eosin stain, original magnification, 40 ×). A: The tumor was composed of blunt finger-like processes lined by pseudostratified columnar cells with frequent goblet cells (arrow); B: Intracellular and extracellular abundant mucin was seen (arrow); C: The carcinomatous areas consisted of dysplastic glands and some of the glands presented with high-grade intraepithelial neoplasia (arrow).

Figure 2 Immunohistochemical analysis of the surgical specimen (magnification, 200 ×). A: Carcinoembryonic antigen was stained positive; B: Cytokeratin 7 was stained positive; C: Cytokeratin 20 was stained positive; D: Epithelial membrane antigen was stained positive; E: The positive ratio of Ki-67 was 60%; F: p53 was stained positive.