Multicomponent metaplastic breast cancer with four histological components: A case report

Figure 1 Tumor and histopathological features. A: Gross specimen obtained after segmental resection of the breast mass, showing the cut surface of the lesion after central incision; B: Histopathological features of mixed metaplastic breast cancer; C: Histopathological features of squamous cell carcinoma (× 100); D: Histopathological features of high-grade ductal carcinoma in situ (× 100); E: Histopathological features of invasive ductal carcinoma (× 100); F: Histopathological features of spindle cell carcinoma (× 100); G: Immunohistochemical staining showing negative expression of estrogen receptor in breast cancer tissue (× 200); H: Immunohistochemical staining showing negative HER2 expression in breast cancer tissue (× 200); I: Immunohistochemical staining showing negative PR expression in breast cancer tissue (× 200); J: Immunohistochemical staining showing positive CK5/6 expression in breast cancer tissue (× 20); K: Immunohistochemical staining revealed positive expression of P40 in breast cancer tissues (× 20); L: Immunohistochemical staining revealed positive expression of P63 in breast cancer tissues (× 20).