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Tamboli Z, Srivastava A, Dhayal IR, Singh S. Laparoscopic nephrectomy in crossed-fused inferior ectopic kidneys - Defusing complexities: A case series. J Minim Access Surg 2025:01413045-990000000-00140. [PMID: 40197669 DOI: 10.4103/jmas.jmas_14_24] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/12/2024] [Accepted: 06/17/2024] [Indexed: 04/10/2025] Open
Abstract
BACKGROUND Crossed fused renal ectopia manifests as an operative challenge to the minimally invasive urologist. Provided that certain preset steps are meticulously followed and the anatomy is understood, it is not a difficult task to operate on these cases. PATIENTS AND METHODS This is a retrospective study of 15 cases at our Dr. RMLIMS, Lucknow over a period of 5 years. RESULTS The mean operative time was 117.3 minutes and the mean blood loss was 99.3 ml. Two arteries were encountered in 53.3 % of cases, but they can vary in number from a single artery to even six, as found in our series. Two veins were found in 46.6 % of cases, and even up to four veins can be found. CONCLUSIONS Tackling a case of crossed fused inferior renal ectopia by laparoscopic simple nephrectomy is possible with ease and confidence, provided that certain steps are carefully followed to minimize the possibility of complications and conversion to open surgery.
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Affiliation(s)
- Zain Tamboli
- Department of Urology and Renal Transplantation, Dr. RMLIMS, Lucknow, Uttar Pradesh, India
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Elmogassabi A, Gul T, Tallai B, Alrayashi M, Abdelkareem M, Ibrahim M, Baker A, Ebrahim M, Alnawasra H, Alhabash S, Salah M. Ureteric Stone Management in Crossed-Fused Renal Ectopia With Bilateral Duplex-Collecting System. Case Rep Urol 2024; 2024:2662107. [PMID: 39421531 PMCID: PMC11486533 DOI: 10.1155/2024/2662107] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2024] [Accepted: 09/02/2024] [Indexed: 10/19/2024] Open
Abstract
Crossed-fused renal ectopia (CFRE) is a rare congenital anomaly where both kidneys are fused on the same side. We report a case of a 52-year-old male patient who presented with central abdominal pain associated with hematuria and dysuria, with a history of left open ureterolithotomy. Abdominal computed tomography (CT) showed an 18-mm left distal ureteric stone and a CFRE with a bilateral duplex-collecting system. Left ureteroscopy and laser lithotripsy with magnetic double-J stent insertion were carried out successfully, and the patient was discharged on the same day in fair general condition.
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Affiliation(s)
- Abdoulhafid Elmogassabi
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Tawiz Gul
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
- College of Medicine, Qatar University, Doha, Qatar
| | - Bela Tallai
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
- College of Medicine, Qatar University, Doha, Qatar
| | - Maged Alrayashi
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Mohamed Abdelkareem
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Mohammed Ibrahim
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Abu Baker
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Mohammed Ebrahim
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Hossameldin Alnawasra
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Salvan Alhabash
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
| | - Morshed Salah
- Urology Section, Surgery Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar
- College of Medicine, Qatar University, Doha, Qatar
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Slinkard PT, Anson A, Specchi S, Frau Tascon M, Muñiz-Moris L, Penninck D, Ondreka NE. Imaging features of renal ectopia and fusion in 13 cats. J Feline Med Surg 2023; 25:1098612X231196810. [PMID: 37791875 PMCID: PMC10812021 DOI: 10.1177/1098612x231196810] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/05/2023]
Abstract
CASE SERIES SUMMARY A retrospective multicenter case series of renal fusion anomalies in cats was investigated. The aim of this study was to describe the imaging characteristics (radiography, ultrasonography and CT) of renal ectopia and fusion in cats. A total of 13 feline patients (median age 9 years) were included in this multicentric retrospective study. Ultrasound was available in 12/13 cases, radiographs in 4/13 cases and CT in 3/13 cases. Of the 13 cases, seven were left to right fusions, four were right to left fusions, one was on the midline and one was in the pelvic inlet. Adopting a human classification system, there were five lump kidneys, four disc kidneys, one horseshoe kidney, one caudal ectopia, one L-shaped kidney and one pelvic kidney. In 2/13 cases, additional congenital malformations were noted, including an azygous continuation of the caudal vena cava and a peritoneal-pericardial diaphragmatic hernia. RELEVANCE AND NOVEL INFORMATION This study provides further description of the imaging findings in feline patients with fused renal ectopia. The morphologic characteristics of the fused kidneys in cats appear similar to what is published in the human literature. Renal fusion might be an incidental finding in cats, but further investigations are necessary to determine their clinical relevance.
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Affiliation(s)
- Powell T Slinkard
- Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA
| | - Augstina Anson
- Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA
| | - Swan Specchi
- Ospedale Veterinario I Portoni Rossi Anicura Italy, Bologna, Italy
| | - Maria Frau Tascon
- Fundació Hospital Clinic Veterinari, Facultat de Veterinària, Universitat Autònoma de Barcelona, Barcelona, Spain
| | | | - Dominique Penninck
- Department of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, USA
| | - Nele Eley Ondreka
- Department of Veterinary Clinical Sciences, Small Animal Clinic-Surgery, Justus-Liebig-University, Giessen, Germany
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4
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Sarhan O, El Helaly A, Al Otay A, Al Bedaiwi K, Al Ghanbar M, Nakshabandi Z. Crossed fused renal ectopia: Diagnosis and prognosis as a single-center experience. J Pediatr Surg 2021; 56:1632-1637. [PMID: 33004190 DOI: 10.1016/j.jpedsurg.2020.08.030] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/05/2020] [Revised: 08/22/2020] [Accepted: 08/24/2020] [Indexed: 10/23/2022]
Abstract
BACKGROUND Crossed fused renal ectopia (CFRE) is a rare congenital malformation. Renal bladder ultrasound (RBUS) is a good tool for establishing the diagnosis, however, additional imaging with a voiding cystourethrogram (VCUG) and dimercaptosuccinic acid scan (DMSA) might be required. We assessed the need for postnatal evaluation and the long-term consequences in patients with this diagnosis. METHODS A retrospective review of the records of all patients diagnosed with CFRE between 2004 and 2014 was done. We included all patients who underwent postnatal evaluation with RBUS, DMSA and VCUG. Long-term radiological and functional outcomes were assessed. RESULTS A total of 29 patients with CFRE were identified. Majority of cases were detected antenatally (79%) and left to right crossed ectopia constituted the majority of cases (65%). RBUS revealed associated hydronephrosis (HN) in 11 patients (38%). DMSA scans confirmed the diagnosis in all patients and showed impaired renal function in 10 ectopic kidneys (34%). Vesicoureteral reflux was detected in 12 patients (41%); one third of them needed surgical intervention. Extra-urinary anomalies were present in 14 patients (48%) mainly of cardiac origin. After a mean follow-up of 4.5 years, 4 patients (14%) with extra-urinary anomalies developed chronic kidney disease and two of them died. CONCLUSIONS Crossed fused renal ectopia is commonly associated with both urinary and extraurinary malformations. Postnatal RBUS is usually sufficient for diagnosis, however, additional imaging may aid for confirming the diagnosis and detection of associated urinary anomalies. Presence of extra-urinary malformations with crossed fused ectopia carries a higher risk of morbidity. TYPE OF THE STUDY Retrospective study [diagnostic/prognostic study]. LEVEL OF EVIDENCE Level IV.
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Affiliation(s)
- Osama Sarhan
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia; Urology and Nephrology Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
| | - Ahmed El Helaly
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
| | - Abdulhakim Al Otay
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
| | - Khaled Al Bedaiwi
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
| | - Mustafa Al Ghanbar
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
| | - Ziad Nakshabandi
- Pediatric Urology Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia
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Ogbetere FE. Left-to-right crossed fused renal ectopia with pyelonephritis mimicking appendix mass. Urol Ann 2021; 13:73-75. [PMID: 33897169 PMCID: PMC8052908 DOI: 10.4103/ua.ua_67_20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2020] [Revised: 07/05/2020] [Accepted: 08/25/2020] [Indexed: 11/22/2022] Open
Abstract
Crossed fused renal ectopia (CFRE) is an uncommon developmental anomaly of the genitourinary system whereby the two kidneys are located on the same side of the body and joined together, while the ureter of the ectopic kidney still enters the bladder in its normal side. CFRE has variable clinical presentations and usually discovered incidentally when patients are investigated for abdominal complaints. Treatment may be conservative when renal function is preserved with no associated symptomatic urological complications. Highlighted here is the unusual presentation of left-to-right CFRE with acute pyelonephritis as an appendix mass in a 19-year-old female.
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Affiliation(s)
- Friday Emeakpor Ogbetere
- Urology Division, Department of Surgery, Edo University, Iyamho, Edo State, Nigeria.,Department of Surgery, Central Hospital, Auchi, Edo State, Nigeria
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Gao X, Fang Z, Lu C, Shen R, Dong H, Sun Y. Management of staghorn stones in special situations. Asian J Urol 2020; 7:130-138. [PMID: 32257806 PMCID: PMC7096693 DOI: 10.1016/j.ajur.2019.12.014] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/27/2019] [Revised: 08/05/2019] [Accepted: 10/18/2019] [Indexed: 12/17/2022] Open
Abstract
Staghorn stones have always been a challenge for urologists, especially in some special situations, such as horseshoe kidney, ectopic kidney, paediatric kidney, and solitary kidney. The treatment of these staghorn stones must be aggressive because they can lead to renal function loss and serious complications. The gold-standard management for staghorn stones is surgical treatment with the aim of clearing the stones and preserving renal function. Treatment methods for staghorn stones have developed rapidly, such as extracorporeal shock wave lithotripsy, retrograde intrarenal surgery, percutaneous nephrolithotomy and laparoscopy and open surgery. Whether the standard procedures for staghorn stones can also apply to these stones in special situations is still not agreed upon. The decision should be made individually according to the circumstances of the patient. In this review, we evaluates the previous studies and comments on the management of staghorn stones under special situations in the hope of guiding the optimal choice for urologists.
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Affiliation(s)
- Xiaofeng Gao
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
| | - Ziyu Fang
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
| | - Chaoyue Lu
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
| | - Rong Shen
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
| | - Hao Dong
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
| | - Yinghao Sun
- Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China
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Elbouti A, Rafai M, Jidane S, Belkouch A, Bakkali H, Belyamani L. [Crossed renal ectopia discovered incidentally: about one case report]. Pan Afr Med J 2019; 33:178. [PMID: 31565139 PMCID: PMC6756803 DOI: 10.11604/pamj.2019.33.178.11152] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2016] [Accepted: 11/20/2016] [Indexed: 11/11/2022] Open
Abstract
Crossed renal ectopia is a rare congenital abnormality, in which the two kidneys are located in the same side. One of the ureters, whose length is adapted to the kidney seat, crosses the median line to implant in the bladder on the opposite side. Renal fusion of the two parenchymas is common and this abnormality is most often asymptomatic and fortuitously discovered. We report the case of a 36-year old patient with no previous pathological history, presenting with crossed renal ectopia incidentally discovered after acute cholecystitis complicated by perivescicular abscess. On the basis of this observation and of the data from the literature, we here discuss the etiopathogenic, clinical, radiological and therapeutic features of this malformation.
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Affiliation(s)
- Anass Elbouti
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
| | - Mostafa Rafai
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
| | - Said Jidane
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
| | - Ahmed Belkouch
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
| | - Hicham Bakkali
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
| | - Lahcen Belyamani
- Pôle des Urgences Médico-chirurgicales, Hôpital Militaire d'Instruction Médicale V, Faculté de Médecine et de Pharmacie de Rabat, Université Mohammed V, Rabat, Maroc
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8
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Loganathan AK, Bal HS. Crossed fused renal ectopia in children: a review of clinical profile, surgical challenges, and outcome. J Pediatr Urol 2019; 15:315-321. [PMID: 31331806 DOI: 10.1016/j.jpurol.2019.06.019] [Citation(s) in RCA: 13] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/03/2019] [Accepted: 06/20/2019] [Indexed: 11/30/2022]
Abstract
INTRODUCTION Crossed fused renal ectopia is a rare congenital malformation, wherein both kidneys are present unilaterally, with the ureter of the crossed kidney opening into the bladder on the contralateral side. It has varied presentation from incidental detection to renal impairment. In this largest series of crossed fused renal ectopia, the authors assessed the clinical profile of these children and also attempted to shed light on the challenges in the surgical management. METHODS It is a retrospective study conducted from January 2009 to July 2018, among patients evaluated for crossed fused ectopia, in the Department of Pediatric Surgery, Christian Medical College, Vellore. Electronic medical records of 36 children were reviewed. Imaging modalities and operative interventions were recorded. Results were analyzed. RESULTS A total of 36 children were found to have crossed fused ectopia, with male preponderance. Most children presented within one year of age with urinary tract infection being the commonest cause. The most common associated anomaly was anorectal malformation. Ultrasound abdomen and pelvis, micturating cystourethrogram, and radionucleotide scans were the imaging modalities preferred for diagnosis and follow-up. Left-to-right ectopia was more common with inferior ectopic variant being the most common. The predominant urological problems include pelviureteric junction obstruction, vesicoureteric junction obstruction, and vescioureteric reflux. Ureteric re-implant was the most common surgery performed followed by pyeloplasty. Pelvi-pelvostomy, uretero-ureterostomy, bladder augment with Mitrofanoff, and other procedures were performed for select cases. CONCLUSION Crossed fused renal ectopia is a challenging entity which requires individualized management plans based on the predominant urological anomaly and the functional status. Surgical options are diverse and are guided toward the symptomatic urological problem with focus on preserving the renal function. The long-term prognosis is good in these children.
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Affiliation(s)
- A K Loganathan
- Department of Pediatric Surgery, Christian Medical College, Vellore, India
| | - H S Bal
- Department of Pediatric Surgery, Christian Medical College, Vellore, India.
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Choi T, Yoo KH, Song R, Lee DG. Lump type crossed fused renal ectopia with bilateral vesicoureteral reflux: A case report. World J Clin Cases 2019; 7:773-777. [PMID: 30968043 PMCID: PMC6448078 DOI: 10.12998/wjcc.v7.i6.773] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/09/2019] [Revised: 01/31/2019] [Accepted: 02/18/2019] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND Crossed fused renal ectopia is a rare congenital anomaly of the ascent of the kidney. This anomaly may be observed as a solitary kidney during initial evaluation. A solitary kidney must be evaluated for associated anomalies such as duplication, horseshoe kidney, or crossed renal ectopia.
CASE SUMMARY An anomaly was observed in a 9-mo-old male child who was subsequently diagnosed with crossed fused renal ectopia and vesicoureteral reflux (VUR). In this condition, recurrent febrile urinary tract infection can be a serious problem, and can easily cause renal damage due to relatively short ureters and high pressure in the kidney.
CONCLUSION To prevent urosepsis and preserve renal function, early diagnosis and proper management including surgical correction should be considered for the management of renal ectopia with VUR.
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Affiliation(s)
- Taesoo Choi
- Koo Han, Yoo, Dong-Gi Lee, Department of Urology, School of Medicine, Kyung Hee University, Seoul 05278, South Korea
| | | | - Ran Song
- Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul 05278, South Korea
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Jallouli W, Sellami A, Chaker K, Bibi M, Ben Chehida MA, Gargouri MM, Abid K, Ben Rhouma S, Nouira Y. About a case of ureteropelvic junction obstruction in L-shaped cross-fused kidney. Urol Case Rep 2018; 20:98-99. [PMID: 30105208 PMCID: PMC6077839 DOI: 10.1016/j.eucr.2018.07.021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/26/2018] [Revised: 07/25/2018] [Accepted: 07/26/2018] [Indexed: 10/31/2022] Open
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Chan SS, Ntoulia A, Khrichenko D, Back SJ, Tasian GE, Dillman JR, Darge K. Role of magnetic resonance urography in pediatric renal fusion anomalies. Pediatr Radiol 2017; 47:1707-1720. [PMID: 28840306 DOI: 10.1007/s00247-017-3927-5] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/27/2017] [Revised: 05/10/2017] [Accepted: 06/09/2017] [Indexed: 11/30/2022]
Abstract
Renal fusion is on a spectrum of congenital abnormalities that occur due to disruption of the migration process of the embryonic kidneys from the pelvis to the retroperitoneal renal fossae. Clinically, renal fusion anomalies are often found incidentally and associated with increased risk for complications, such as urinary tract obstruction, infection and urolithiasis. These anomalies are most commonly imaged using ultrasound for anatomical definition and less frequently using renal scintigraphy to quantify differential renal function and assess urinary tract drainage. Functional magnetic resonance urography (fMRU) is an advanced imaging technique that combines the excellent soft-tissue contrast of conventional magnetic resonance (MR) images with the quantitative assessment based on contrast medium uptake and excretion kinetics to provide information on renal function and drainage. fMRU has been shown to be clinically useful in evaluating a number of urological conditions. A highly sensitive and radiation-free imaging modality, fMRU can provide detailed morphological and functional information that can facilitate conservative and/or surgical management of children with renal fusion anomalies. This paper reviews the embryological basis of the different types of renal fusion anomalies, their imaging appearances at fMRU, complications associated with fusion anomalies, and the important role of fMRU in diagnosing and managing children with these anomalies.
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Affiliation(s)
- Sherwin S Chan
- Department of Radiology, Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.
| | - Aikaterini Ntoulia
- Division of Body Imaging, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
| | - Dmitry Khrichenko
- Division of Body Imaging, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
| | - Susan J Back
- Division of Body Imaging, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
| | - Gregory E Tasian
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Division of Urology, Department of Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
| | - Jonathan R Dillman
- Division of Thoracoabdominal Imaging, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
| | - Kassa Darge
- Division of Body Imaging, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
- Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
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Bhattar R, Maheshwari A, Tomar V, Yadav SS. Crossed Fused Ectopic Kidney: A Case Report. J Clin Diagn Res 2017; 11:PD11-PD12. [PMID: 28969201 DOI: 10.7860/jcdr/2017/26944.10434] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/23/2017] [Accepted: 05/31/2017] [Indexed: 11/24/2022]
Abstract
Crossed fused ectopic kidney is an unusual congenital malformation of the urinary tract. This condition is usually identified in the autopsy specimen rather than in general clinical scenario. In this condition, both kidneys are located on one side of the midline and are fused with each other. This condition is generally asymptomatic and usually diagnosed as incidental finding. We came across a case of crossed fused left to right ectopia with inferior infusion with nephroptosis. Generally, in cases of crossed fused renal ectopia, one kidney is lower than the other one but in our report, both kidneys were present at the same level. Initially it was thought as cake kidney, but on careful inspection diagnosis of crossed fused left to right ectopia with inferior infusion was made. During workup of abdominal pain, this finding was detected with no gross abnormality except for a tiny calculus. After detailed discussion with the patient, regular follow up was done without any active intervention and during that period he remained clinically and radiologically stable. So in these conditions active intervention is not always mandatory and patient may remain asymptomatic without any intervention.
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Affiliation(s)
- Rohit Bhattar
- Mch Urology Resident, Department of Urology and Renal Transplantation, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
| | - Anuradha Maheshwari
- Clinical Associate, Department of Anaesthesia, Eternal Hospital, Jaipur, Rajasthan, India
| | - Vinay Tomar
- Professor and Head, Department of Urology and Renal Transplantation, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
| | - Sher Singh Yadav
- Professor and Head, Department of Urology and Renal Transplantation, Sawai Man Singh Medical College, Jaipur, Rajasthan, India
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13
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Crossed fused renal ectopia: case report and review of the literature. J Ultrasound 2017; 20:333-337. [PMID: 29204238 DOI: 10.1007/s40477-017-0245-6] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2016] [Accepted: 03/16/2017] [Indexed: 10/19/2022] Open
Abstract
Crossed fused renal ectopia is a rare congenital anomaly, and is mostly detected incidentally. A 45-year-old man, during investigation for recurrent abdominal pain, was found to have an empty left renal fossa and right crossed renal ectopia with fusion on ultrasonography. In the present case, there were no abnormalities and/or alteration of the renal function. Abdominal tomography scan with contrast medium confirmed the diagnosis. Ectopic kidney is often associated with other abnormal situations such as agenesis, vascular malformation, incontinence, a palpable abdominal mass, urinary tract infection, high incidence of stone formation, and genital anomalies. Through this case report, we emphasize the importance of adequate imaging.
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14
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Seo SH, Lee HA, Suh SI, Choi R, Park IC, Hyun C. Crossed fused renal ectopia in a Persian cat. JFMS Open Rep 2017; 3:2055116917695875. [PMID: 28491454 PMCID: PMC5415293 DOI: 10.1177/2055116917695875] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
Case summary This report describes a rare case of crossed fused renal ectopia (CFRE) in a cat. A mature intact male Persian cat presented with bloody nasal discharge and ascites. Diagnostic studies revealed an ectopic left kidney fused with an orthotopic right kidney and a concurrent feline infectious peritonitis (FIP) infection. The FIP was responsible for clinical signs in this cat, while clinical signs associated with CFRE were not obvious. Despite receiving intensive treatment, the cat died. A post-mortem examination was not performed because the owners declined approval. Relevance and novel information To the best of our knowledge, this is the first report of L-shaped CFRE in a cat. In addition, this report describes the CT features of L-shaped CFRE in a cat.
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Affiliation(s)
- Sang-Hyuk Seo
- VIP Animal Medical Center, Seoul, Korea.,Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea
| | | | - Sang-Il Suh
- Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea
| | - Ran Choi
- Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea
| | - In-Chul Park
- Section of Diagnostic Imaging, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea
| | - Changbaig Hyun
- Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University, Chuncheon, Korea
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Naseri M. Cross-fused renal ectopia associated with vesicoureteral reflux; a case report. J Renal Inj Prev 2016; 5:200-2. [PMID: 27689123 PMCID: PMC5039989 DOI: 10.15171/jrip.2016.42] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/28/2016] [Accepted: 07/26/2016] [Indexed: 12/03/2022] Open
Abstract
Crossed renal ectopia is a rare urinary system anomaly which mostly is asymptomatic and is diagnosed incidentally. Urinary obstruction, infection, and neoplasia of the urinary system and nephrolithiasis are main complications of this anomaly. A 6-year-old boy admitted to the hospital with colicky abdominal pain and nausea. Abdominal examination revealed tenderness in right lower quadrant. Urine analysis and culture were normal. Kidney ultrasonography showed right kidney in pelvis cavity with no kidney tissue in left side. TC 99-DMSA scan demonstrated no radiotracer accumulation in the normal renal area. Radiotracer accumulation was seen in the pelvis area with a deviation to the left. Voiding cystoureterogram revealed right sided grade II vesicoureteral reflux. Severe urological anomalies in children may be asymptomatic or have nonspecific symptoms such as abdominal pain.
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Affiliation(s)
- Mitra Naseri
- Pediatric Nephrology Department, Dr Sheikh Children Hospital, Mashhad University of Medical sciences, Mashhad, Iran
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16
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Crossed Fused Renal Ectopia Diagnosed After Discovering an Absent Left Kidney by Point-of-Care Ultrasound. Pediatr Emerg Care 2016; 32:56-7. [PMID: 26720068 DOI: 10.1097/pec.0000000000000671] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
Abstract
We report an incidental diagnosis of crossed fused renal ectopia diagnosed in a patient initially evaluated with an educational point-of-care ultrasound (US). We review the US technique, sonographic findings, and the relevant literature regarding renal US.
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17
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Tandem kidney. APOLLO MEDICINE 2015. [DOI: 10.1016/j.apme.2015.05.016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022] Open
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18
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Musiienko A, Simpson JAD, Murphy D, Thomson B, Heriot A. Low anterior resection adjacent to a pancake kidney: case report. ANZ J Surg 2015; 87:E333-E334. [PMID: 26011689 DOI: 10.1111/ans.13198] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022]
Affiliation(s)
- Anton Musiienko
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | | | - Declan Murphy
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | - Benjamin Thomson
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
| | - Alexander Heriot
- Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
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19
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The Rarest of the Rare: Crossed Fused Renal Ectopia of the Superior Ectopia Type. Case Rep Nephrol 2015; 2015:742419. [PMID: 26064722 PMCID: PMC4429221 DOI: 10.1155/2015/742419] [Citation(s) in RCA: 15] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2015] [Accepted: 03/25/2015] [Indexed: 11/19/2022] Open
Abstract
Crossed fused renal ectopia is a rare congenital anomaly of the urinary system where one kidney crosses over to opposite side and the parenchyma of the two kidneys fuse. Herein, we present an atypical CFRE case whose renal anatomy does not exactly match any of the already defined CFRE types. Both of the kidneys are ectopic with the crossed ectopic right kidney lying superiorly and fused to the upper pole of the left kidney. Renal arteries were originating from the common iliac arteries. A focal 90% stenosis was observed on the right main renal artery. The patient is borderline hypertensive.
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20
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Yalcin EG, He Y, Orhan D, Pazzagli C, Emiralioglu N, Has C. Crucial role of posttranslational modifications of integrin α3 in interstitial lung disease and nephrotic syndrome. Hum Mol Genet 2015; 24:3679-88. [PMID: 25810266 DOI: 10.1093/hmg/ddv111] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/22/2015] [Accepted: 03/23/2015] [Indexed: 01/06/2023] Open
Abstract
Interstitial lung disease, nephrotic syndrome and junctional epidermolysis bullosa is an autosomal recessive multiorgan disorder caused by mutations in the gene for the integrin α3 subunit (ITGA3). The full spectrum of manifestations and genotype-phenotype correlations is still poorly characterized. Here, we uncovered the disease-causing role and the molecular mechanisms underlying a homozygous ITGA3 mutation leading to the single amino acid substitution, p.R463W. The patient suffered from respiratory distress and episodes of cyanosis with onset in the first week of life and had a nephrotic syndrome. Although there was no clinical evidence for cutaneous fragility, the analysis of a skin sample and of skin epithelial cells enabled the direct assessment of the authentic mutant protein. We show that the mutation altered the conformation of the extracellular β-propeller domain of the integrin α3 subunit preventing correct processing of N-linked oligosaccharides, heterodimerization with β1 integrin and maturation through cleavage into heavy and light chains in the Golgi. Confocal microscopy demonstrated that the mutant protein accumulated intracellularly, but it was not present in focal adhesions or on the cell membrane as shown by flow cytometry. These findings highlight that single amino acid changes in the integrin α3 subunit may crucially alter the structure and complex processing of this integrin, completely preventing its functionality. The present report also underscores that ITGA3 mutations may account for atypical cases solely with early onset respiratory and renal involvement.
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Affiliation(s)
| | - Yinghong He
- Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany and
| | - Diclehan Orhan
- Department of Pediatric Pathology, Hacettepe University Faculty of Medicine, Ankara, Turkey
| | - Chiara Pazzagli
- Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany and Spemann Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Freiburg, Germany
| | | | - Cristina Has
- Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany and
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21
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Bhojwani N, Hartman JB, Ahmed M, Morgan R, Davidson JC. Management of ureteral obstruction in crossed fused renal ectopia: A case report. Can Urol Assoc J 2014; 8:E752-4. [PMID: 25408820 DOI: 10.5489/cuaj.2050] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/19/2022]
Abstract
Crossed fused renal ectopia is a rare congenital malformation. We describe a case in which a 58-year-old male with left-sided crossed fused renal ectopia presented with urinary bladder outlet obstruction due to metastatic prostate adenocarcinoma. Glomerular filtration rate (GFR) was 13 mL/min, creatinine 4 mg/dL, and blood urea nitrogen (BUN) 58 mg/dL. The patient underwent successful image-guided placement of percutaneous nephrostomy tubes which were later converted to nephroureteral stents. Labs improved to a GFR of 28 mL/min, creatinine of 2.4 mg/dL, and BUN of 41 mg/dL. In this case standard image-guided renal decompression techniques were effective in treating a patient with crossed fused renal ectopia.
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Affiliation(s)
- Nicholas Bhojwani
- Department of Radiology, University Hospitals Case Medical Center, Cleveland, OH
| | | | - Manzoor Ahmed
- Division of Vascular and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, OH
| | - Robert Morgan
- Case Western Reserve University School of Medicine, Cleveland, OH; ; Explorys Inc., Cleveland, OH
| | - Jon C Davidson
- Division of Vascular and Interventional Radiology, University Hospitals Case Medical Center, Cleveland, OH
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22
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Diagnosis of rare association of orthotopic multicystic dysplasia with crossed fused renal ectopia. Case Rep Urol 2014; 2014:140850. [PMID: 24839577 PMCID: PMC4009279 DOI: 10.1155/2014/140850] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2014] [Accepted: 03/08/2014] [Indexed: 11/17/2022] Open
Abstract
Orthotopic multicystic dysplastic kidney with crossed fused ectopia is a rare congenital anomaly. This congenital anomaly may give an appearance of a solitary kidney morphology during the initial imaging evaluation. A solitary kidney should be carefully evaluated for the presence of duplication, horseshoe configuration, or crossed renal ectopy. Vesicoureteral reflux is a common finding associated with a multicystic dysplastic kidney. We present an infant with an orthotopic multicystic dysplastic kidney and an inferiorly placed crossed fused ectopic kidney. The presence of a complex congenital anomaly may warrant further evaluation with cross-sectional imaging to depict the anatomy and structure.
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Affiliation(s)
- Kavita Bhatt
- Imaging Institute, Cleveland Clinic, Cleveland, Ohio
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24
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Solanki S, Bhatnagar V, Gupta AK, Kumar R. Crossed fused renal ectopia: Challenges in diagnosis and management. J Indian Assoc Pediatr Surg 2013; 18:7-10. [PMID: 23599575 PMCID: PMC3628252 DOI: 10.4103/0971-9261.107006] [Citation(s) in RCA: 45] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/08/2022] Open
Abstract
Aim: Crossed fused renal ectopia is a rare congenital malformation, which is reported to be usually asymptomatic but may have varied presentations. This survey was conducted to study the clinical profile and the challenges posed in the management of this entity. Materials and Methods: Retrospective analysis of 6 patients diagnosed to have crossed fused renal ectopia during 1997-2010. The diagnosis was confirmed during surgical exploration in one patient. In one patient it was detected on antenatal ultrasonography and in the other 4 patients it was detected during investigations for abdominal pain, abdominal mass, anorectal malformation and urinary tract infection. Results: The left moiety was crossed and fused with the right moiety in 4 cases. Ultrasonography was found to be a good screening investigation with useful diagnostic contributions from CT scans, radionuclide scintigraphy and magnetic resonance urography. Micturating cystourethrography revealed presence of VUR in 4 cases, 3 of whom have undergone ureteric reimplantation. Two patients required pyeloplasty for pelviureteric junction obstruction; in one of these patients the upper ureter was entrapped in the isthmus. In one patient, a non-functioning moiety resulted in nephrectomy. All children were asymptomatic at last follow-up with stable renal functions. Conclusions: Crossed fused renal ectopia was detected in most patients during investigation for other problems. It was found more commonly in boys. The left moiety was crossed to the right in the majority of cases. Associated urological problems were found in most cases and required the appropriate surgical management.
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Affiliation(s)
- Shailesh Solanki
- Department of Pediatric Surgery, All India Institute Medical Sciences, New Delhi, India
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Mally AD, Fox JA, Cannon GC. Ureteral Ectopia Inserting into Ipsilateral Epididymis Resulting in Inflammatory Paratesticular Tumor. Urology 2012; 80:710-3. [DOI: 10.1016/j.urology.2012.04.037] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/08/2012] [Revised: 04/17/2012] [Accepted: 04/20/2012] [Indexed: 11/25/2022]
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26
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Chang PL, Mrazek-Pugh B, Blumenfeld YJ. Prenatal diagnosis of cross-fused renal ectopia: does color Doppler and 3-dimensional sonography help? JOURNAL OF ULTRASOUND IN MEDICINE : OFFICIAL JOURNAL OF THE AMERICAN INSTITUTE OF ULTRASOUND IN MEDICINE 2011; 30:578-580. [PMID: 21460160 DOI: 10.7863/jum.2011.30.4.578] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/30/2023]
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27
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Liu L, Yang J, Zhu L, Yi L, Zhu B, Song W, Zhang W, Gong Y. Crossed-fused Renal Ectopia Associated With Inverted-Y Ureteral Duplication, Ectopic Ureter, and Bicornuate Uteruses. Urology 2010; 75:1175-7. [DOI: 10.1016/j.urology.2010.02.037] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/01/2010] [Revised: 02/09/2010] [Accepted: 02/15/2010] [Indexed: 12/11/2022]
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