Baishideng Publishing Group

Toyoshima O, Nishizawa T, Yoshida S, Aoki T, Nagura F, Sakitani K, Tsuji Y, Nakagawa H, Suzuki H, Koike K. Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer. World J Gastrointest Endosc 2021; 13(5): 125-136 [DOI: 10.4253/wjge.v13.i5.125]

"Thank you for allowing us to publish our paper titled “Biomarkers for hepatocellular carcinoma based on body fluids and feces” ..." [Read more]

"Thank you for allowing us to publish our paper titled “Biomarkers for hepatocellular carcinoma based on body fluids and feces” (Manuscript NO. 61866) in World Journal of Gastrointestinal Oncology. We are very satisfied with the manuscript editing and publishing process as well as the peer review process. And we greatly appreciate the efficient, professional and rapid processing of our paper by your team as well as reviewers’ positive and constructive comments." [Collapse]

Guan MC, Ouyang W, Wang MD, Liang L, Li N, Fu TT, Shen F, Lau WY, Xu QR, Huang DS, Zhu H, Yang T. Biomarkers for hepatocellular carcinoma based on body fluids and feces. World J Gastrointest Oncol 2021; 13(5): 351-365 [DOI: 10.4251/wjgo.v13.i5.351]

"A very comprehensive and robust review and editing system"

Asaad P, O’Connor A, Hajibandeh S, Hajibandeh S. Meta-analysis and trial sequential analysis of randomized evidence comparing general anesthesia vs regional anesthesia for laparoscopic cholecystectomy. World J Gastrointest Endosc 2021; 13(5): 137-154 [DOI: 10.4253/wjge.v13.i5.137]

"The column of 'Selected studies (Cohort)" in Table 1 showed some "-" mark. The author wish to show the number of cohorts as ( ). ..." [Read more]

"The column of 'Selected studies (Cohort)" in Table 1 showed some "-" mark. The author wish to show the number of cohorts as ( ). Replace "-" into "( )", please." [Collapse]

Bae JM. Sex as an effect modifier in the association between alcohol intake and gastric cancer risk. World J Gastrointest Oncol 2021; 13(5): 453-461 [DOI: 10.4251/wjgo.v13.i5.453]

"Baishideng was the first company who accepted my paper and I will try my best to submit more and more high quality manuscript to the ..." [Read more]

"Baishideng was the first company who accepted my paper and I will try my best to submit more and more high quality manuscript to the website." [Collapse]

Li C, Wang Q, Jiang KW. What is the best surgical procedure of transverse colon cancer? An evidence map and minireview. World J Gastrointest Oncol 2021; 13(5): 391-399 [DOI: 10.4251/wjgo.v13.i5.391]

"Overall we are very satisfied and happy to work with the publishers again for future articles."

King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE. Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers. World J Gastrointest Oncol 2021; 13(5): 312-331 [DOI: 10.4251/wjgo.v13.i5.312]

"On the whole, we are very satisfied with the service of your magazine！"

Dong XH, Dai D, Yang ZD, Yu XO, Li H, Kang H. S100 calcium binding protein A6 and associated long noncoding ribonucleic acids as biomarkers in the diagnosis and staging of primary biliary cholangitis. World J Gastroenterol 2021; 27(17): 1973-1992 [DOI: 10.3748/wjg.v27.i17.1973]

"no"

Wang CC, Tsai MC, Sung WW, Yang TW, Chen HY, Wang YT, Su CC, Tseng MH, Lin CC. Risk of cholangiocarcinoma in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography or cholecystectomy: A population based study. World J Gastrointest Oncol 2019; 11(3): 238-249 [PMID: 30918596 DOI: 10.4251/wjgo.v11.i3.238]

"no"

Chia KJ, Lin LH, Sung MT, Su TM, Huang JF, Lee HL, Sung WW, Lee TH. Acute spontaneous thoracic epidural hematoma associated with intraspinal lymphangioma: A case report. World J Clin Cases 2021; 9(14): 3411-3417 [DOI: 10.12998/wjcc.v9.i14.3411]

"Dear Editorial Team Thank you for the opportunity. Kudos!! To the Editorial team for a very transparent process of article ..." [Read more]

"Dear Editorial Team Thank you for the opportunity. Kudos!! To the Editorial team for a very transparent process of article processing. There is some problem with E-mail server. I did not receive any e-mail during the process of peer review, revisions or final processing. Kindly check this one out. Only other comment is on publication process, which could have been faster. However COVID-19 has affected many processes, we understand the delay. Regards Dr Prashant Nasa" [Collapse]

Nasa P, Chaudhary S, Shrivastava PK, Singh A. Euglycemic diabetic ketoacidosis: A missed diagnosis. World J Diabetes 2021; 12(5): 514-523 [DOI: 10.4239/wjd.v12.i5.514]

"While publishing, we were requested to provide an evidence that all the grant we mentioned in the manuscript are valid. This is first ..." [Read more]

"While publishing, we were requested to provide an evidence that all the grant we mentioned in the manuscript are valid. This is first time ever a journal asked me to provide such information, which made me feeling disappointed. I would also appreciate a better communication process with the editorial office. Not all my emails were answered. Moreover, we never received any notification via email once the peer-review process was completed. Not sure if this misleading communication happened due to our IT department restrictions for the outside emails or this is the journal's normal way to communicate." [Collapse]

Mitrofanova A, Burke G, Merscher S, Fornoni A. New insights into renal lipid dysmetabolism in diabetic kidney disease. World J Diabetes 2021; 12(5): 524-540 [DOI: 10.4239/wjd.v12.i5.524]

"Nice job. Pleasure to contribute to World Journals."

Montada-Atin T, Prasad GVR. Recent advances in new-onset diabetes mellitus after kidney transplantation. World J Diabetes 2021; 12(5): 541-555 [DOI: 10.4239/wjd.v12.i5.541]

"Dear Editors, All authors are satisfied with the entire process from submission to editing. The F6 platform has a very friendly user ..." [Read more]

"Dear Editors, All authors are satisfied with the entire process from submission to editing. The F6 platform has a very friendly user interface, and all steps in general flowed smoothly. We would also like to thank the reviewers for their insightful comments and the speed of the peer review process." [Collapse]

Rojas A, Lindner C, Gonzàlez I, Morales MA. Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients. World J Diabetes 2021; 12(5): 590-602 [DOI: 10.4239/wjd.v12.i5.590]

"We are satisfied with all the procedure. This is an effective journal."

Miao XY, Wang XL, Lyu ZH, Ba JM, Pei Y, Dou JT, Gu WJ, Du J, Guo QH, Chen K, Mu YM. Paget’s disease of bone: Report of 11 cases. World J Clin Cases 2021; 9(14): 3478-3486 [DOI: 10.12998/wjcc.v9.i14.3478]

"As an author of the manuscript published in WJD I am satisfied with the review and publishing process."

Cigrovski Berkovic M, Bilic-Curcic I, La Grasta Sabolic L, Mrzljak A, Cigrovski V. Fear of hypoglycemia, a game changer during physical activity in type 1 diabetes mellitus patients. World J Diabetes 2021; 12(5): 569-577 [DOI: 10.4239/wjd.v12.i5.569]

"no comments"

Di Ciaula A, Portincasa P. Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children: An ecologic study. World J Diabetes 2021; 12(5): 673-684 [DOI: 10.4239/wjd.v12.i5.673]

"Peer review process seems a bit slower compared to when I serve as a reviewer for your journal."

Onyishi CN, Ilechukwu LC, Victor-Aigbodion V, Eseadi C. Impact of spiritual beliefs and faith-based interventions on diabetes management. World J Diabetes 2021; 12(5): 630-641 [DOI: 10.4239/wjd.v12.i5.630]

"The overall submission and processing system is very well organized, the revision and the publishing procedure is straightforward, ..." [Read more]

"The overall submission and processing system is very well organized, the revision and the publishing procedure is straightforward, thanks for the support in the work, Best Regards" [Collapse]

Chinnici CM, Russelli G, Bulati M, Miceli V, Gallo A, Busà R, Tinnirello R, Conaldi PG, Iannolo G. Mesenchymal stromal cell secretome in liver failure: Perspectives on COVID-19 infection treatment. World J Gastroenterol 2021; 27(17): 1905-1919 [DOI: 10.3748/wjg.v27.i17.1905]

"We are pleased with the process of the publication."

Heda R, Yazawa M, Shi M, Bhaskaran M, Aloor FZ, Thuluvath PJ, Satapathy SK. Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect. World J Gastroenterol 2021; 27(17): 1864-1882 [DOI: 10.3748/wjg.v27.i17.1864]

"The peer review comments were fair. The submission process was smooth. Overall, I have no complaints with the peer review or submission ..." [Read more]

"The peer review comments were fair. The submission process was smooth. Overall, I have no complaints with the peer review or submission process." [Collapse]

Caicedo L, Wasuwanich P, Rivera A, Lopez MS, Karnsakul W. Chilaiditi syndrome in pediatric patients - Symptomatic hepatodiaphragmatic interposition of colon: A case report and review of literature. World J Clin Pediatr 2021; 10(3): 40-47 [DOI: 10.5409/wjcp.v10.i3.40]

5640 items Read more >>

Article Quality Tracking-Peer-Review

"This is a very interesting study to demonstrate the association between alcohol intake and gastric cancer development. As the most ..." [Read more]

"This is a very interesting study to demonstrate the association between alcohol intake and gastric cancer development. As the most important risk factor of gastric cancer is Helicobacter pylori infection, infection rate of H. pylori would influence the result of this study. I consider that the association between alcohol intake and gastric cancer is more significant in area where infection rate is low, for example, in Western countries. Further study to evaluate the association with H. pylori infection is strongly expected in the future. " [Collapse]

Bae JM. Sex as an effect modifier in the association between alcohol intake and gastric cancer risk. World J Gastrointest Oncol 2021; 13(5): 453-461 [DOI: 10.4251/wjgo.v13.i5.453]

"In this review article the authors summarized the most recent advances in the application of AI and machine learning technologies ..." [Read more]

"In this review article the authors summarized the most recent advances in the application of AI and machine learning technologies in the diagnosis and risk prediction, assessment of disease severity, and prediction of clinical outcomes in patients with IBD. The article is very well conceived and contains very important and the-state-of the-art information. The three very extensive and superbly designed tables: Table 1: AI in diagnosis and risk prediction of IBD; Table 2: AI in assessment of disease severity in IBD and Table 3: AI in prediction of therapy response and clinical outcomes in IBD are excellent and provide the newest available information. These are very important because despite several IBD treatment options available to clinicians, there are no effective biomarkers or tools to predict response to therapy or to guide selection of alternative therapies after a failed response. Also, there is also an unmet clinical need to predict long term clinical outcomes in IBD such as colon cancer. The article is very well written and is in my opinion a must read for all physician caring for the IBD patients. " [Collapse]

Gubatan J, Levitte S, Patel A, Balabanis T, Wei MT, Sinha SR. Artificial intelligence applications in inflammatory bowel disease: Emerging technologies and future directions. World J Gastroenterol 2021; 27(17): 1920-1935 [DOI: 10.3748/wjg.v27.i17.1920]

"major problems Study is retrospective. In the abstract under results ,no mention about the blood pressure given Study population ..." [Read more]

"major problems Study is retrospective. In the abstract under results ,no mention about the blood pressure given Study population is good for obesity. However a significant number of them had no hypertension. Among those the improvement is only modest. " [Collapse]

Samuel GO, Lambert K, Asagbra E, Harvin G, Ibegbu E. Impact of intragastric balloon on blood pressure reduction: A retrospective study in Eastern North Carolina. World J Gastrointest Endosc 2021; 13(5): 115-124 [DOI: 10.4253/wjge.v13.i5.115]

"Nice study. Validation of propsed Lauren predictive background score will be interesting. "

"Well written manuscript."

"Interesting paper, whose findings are of wide interest for the scientific community. Congratulations to authors."

Bae JM. Sex as an effect modifier in the association between alcohol intake and gastric cancer risk. World J Gastrointest Oncol 2021; 13(5): 453-461 [DOI: 10.4251/wjgo.v13.i5.453]

"A manuscript of importance but in its specific field"

Elsayed M, Loya M, Galt J, Schuster DM, Bercu ZL, Newsome J, Brandon D, Benenati S, Behbahani K, Duszak R, Sethi I, Kokabi N. Same day yttrium-90 radioembolization with single photon emission computed tomography/computed tomography: An opportunity to improve care during the COVID-19 pandemic and beyond. World J Gastrointest Oncol 2021; 13(5): 440-452 [DOI: 10.4251/wjgo.v13.i5.440]

"The most appreciated part of this interesting paper is the statistical analysis, which has been properly performed. The overall message ..." [Read more]

"The most appreciated part of this interesting paper is the statistical analysis, which has been properly performed. The overall message is of interest." [Collapse]

Elshaarawy O, Aman A, Zakaria HM, Zakareya T, Gomaa A, Elshimi E, Abdelsameea E. Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis. World J Gastrointest Oncol 2021; 13(5): 424-439 [DOI: 10.4251/wjgo.v13.i5.424]

"An interesting report. More tables and figures may be of greater help in the comprehesion of the main messages."

McCaughan H, Boyle S, McGoran JJ. Update on the management of the gastrointestinal effects of radiation. World J Gastrointest Oncol 2021; 13(5): 400-408 [DOI: 10.4251/wjgo.v13.i5.400]

"This is a very clear mini-review, short but well-structured manuscript. Although the discussion of the main topics might be more ..." [Read more]

"This is a very clear mini-review, short but well-structured manuscript. Although the discussion of the main topics might be more detailed, the most important topic have been described. Congratulations to the authors." [Collapse]

"Comprehensive review, appreciated for the important messages with clinical implications."

"Excellent study. Congratulations to authors. The topic is very important, too."

"Liquid biopsy is a very hot topic in oncology. it has, first of all, diagnostic, prognostic and predictive roles. This manuscript ..." [Read more]

"Liquid biopsy is a very hot topic in oncology. it has, first of all, diagnostic, prognostic and predictive roles. This manuscript is comprehensive but the structure cannot be appreciated so much by many readers, since an organization/structure of manuscript divided by the three main topic above indicated would help in improving the comprehension by the readers. More space shoudl be dedicated to the topic of liquid biopsy introduction into clinical practice." [Collapse]

Rompianesi G, Di Martino M, Gordon-Weeks A, Montalti R, Troisi R. Liquid biopsy in cholangiocarcinoma: Current status and future perspectives. World J Gastrointest Oncol 2021; 13(5): 332-350 [DOI: 10.4251/wjgo.v13.i5.332]

"This is a nice mini-review, with a comprehensive part on histology. the only considerations that i can move regards genetic syndromes. ..." [Read more]

"This is a nice mini-review, with a comprehensive part on histology. the only considerations that i can move regards genetic syndromes. Some of the tumor types you described arise in the context of genetic syndrome (e.g. neurofibromatosis type 1), thus more attention should be paid to this aspects, ideally with a specific paragraph on this peculiar genetic setting." [Collapse]

Arslan ME, Li H, Fu Z, Jennings TA, Lee H. Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis. World J Gastrointest Oncol 2021; 13(5): 409-423 [DOI: 10.4251/wjgo.v13.i5.409]

"How is it possible to write "caner" and not "cancer" in the title? Authors should read carefully their own manuscripts. otherwise ..." [Read more]

"How is it possible to write "caner" and not "cancer" in the title? Authors should read carefully their own manuscripts. otherwise the manuscript is comprehensive. I would see more figures and not so complicated. In the paragraph on TGF-beta, some sentences regarding SMAD4 would be appreciated." [Collapse]

Matsuoka T, Yashiro M. Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. World J Gastrointest Oncol 2021; 13(5): 366-390 [DOI: 10.4251/wjgo.v13.i5.366]

"The present review mainly talked about the characteristics of insulin resistance in different tissues. Ovaries and the adrenal glands ..." [Read more]

"The present review mainly talked about the characteristics of insulin resistance in different tissues. Ovaries and the adrenal glands are two examples of tissues remaining sensitive to insulin actions where insulin may contribute to increased androgen secretion leading to androgen excess disorders. Therefore, they conclude that the role and contribution of hyperinsulinemia triggered by (selective) insulin resistance has paramount importance for elucidating the pathogenesis of these disorders and establishing the right patient for insulin sensitizer therapy. All the sections sounds great. " [Collapse]

Unluhizarci K, Karaca Z, Kelestimur F. Role of insulin and insulin resistance in androgen excess disorders. World J Diabetes 2021; 12(5): 616-629 [DOI: 10.4239/wjd.v12.i5.616]

"The application of AI in solid tumor is evaluated. The topic and investigation of AI application is very important."

Shao Y, Zhang YX, Chen HH, Lu SS, Zhang SC, Zhang JX. Advances in the application of artificial intelligence in solid tumor imaging. Artif Intell Cancer 2021; 2(2): 12-24 [DOI: 10.35713/aic.v2.i2.12]

"The topic on application of AI in colorectal cancer is very important. "

Alloro R, Sinagra E. Artificial intelligence and colorectal cancer: How far can you go? Artif Intell Cancer 2021; 2(2): 7-11 [DOI: 10.35713/aic.v2.i2.7]

"It is generally a good review. The authors mainly discussed the chronic care model (CCM) in relation to the diabetes ..." [Read more]

"It is generally a good review. The authors mainly discussed the chronic care model (CCM) in relation to the diabetes pay-for-performance (P4P) program in Taiwan in the present review. They introduce the 6 components of the CCM and provide a detailed description of each of the activities in the P4P program implemented in Taiwan, mapping them onto the 6 components of the CCM. And described in detail about the definition of the CCM component, the general activities implemented and empirical practices based on hospital or local government cases. Finally they analyzed the possible successful features of this P4P program and its challenges and future directions. The good points are worthy of others to learn. " [Collapse]

Chen TT, Oldenburg B, Hsueh YS. Chronic care model in the diabetes pay-for-performance program in Taiwan: Benefits, challenges and future directions. World J Diabetes 2021; 12(5): 578-589 [DOI: 10.4239/wjd.v12.i5.578]

"Euglycemia diabetic ketoacidosis (DKA) is an interesting topic, especially with the increasing application of SGLT-2 inhibitors. ..." [Read more]

"Euglycemia diabetic ketoacidosis (DKA) is an interesting topic, especially with the increasing application of SGLT-2 inhibitors. Neglects of such condition would be lead to a bad outcome for those high risk diabetic patients. As the authors said, SGLT-2 inhibitors are the latest group of medications added to treat patients with DM. Their promotion in type 2 DM is due to clinical trials suggesting protection against major adverse cardiovascular events and reduced hospitalization for heart failure and deaths. SGLT-2 inhibitors have also been shown to slow chronic kidney disease progression in type 2 DM. However, we absolutely need to pay great attention to high risk patients, like tell the patient drink more water and take enough carbonate, not prescribing this kind drug to those already with low carbonate." [Collapse]

Nasa P, Chaudhary S, Shrivastava PK, Singh A. Euglycemic diabetic ketoacidosis: A missed diagnosis. World J Diabetes 2021; 12(5): 514-523 [DOI: 10.4239/wjd.v12.i5.514]

6509 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 3704

Peer-reviewers: 40311

Manuscripts received today: 0

Manuscript reviews today: 18

Unhandled manuscripts today: 115

Active peer-reviewers today: 46

Reviewer acceptance today: 8

Reviewer refusals today: 7

Total accepted manuscripts: 20798

Total rejected manuscripts: 25918

Total peer-reviewers: 657801

Total submissions: 17833

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

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All Journal Articles

Miao XY, Wang XL, Lyu ZH, Ba JM, Pei Y, Dou JT, Gu WJ, Du J, Guo QH, Chen K, Mu YM. Paget’s disease of bone: Eleven case reports. World J Clin Cases 2021; 9(14): 3478-3486

2021-05-16 | Browse: 390 | Download: 56

Moon SK, Yoo JJ, Kim SG, Kim YS. Extremely rare case of necrotizing gastritis in a patient with autoimmune hepatitis: A case report. World J Clin Cases 2021; 9(14): 3472-3477

2021-05-16 | Browse: 346 | Download: 42

Jiang D, Tang GD, Lai MY, Huang ZN, Liang ZH. Cronkhite-Canada syndrome with steroid dependency: A case report. World J Clin Cases 2021; 9(14): 3466-3471

2021-05-16 | Browse: 324 | Download: 42

Chen XX, Shao SJ, Wan H. Diabetic mastopathy in the elderly easily misdiagnosed as breast cancer: A case report and review of literature. World J Clin Cases 2021; 9(14): 3458-3465

2021-05-16 | Browse: 326 | Download: 33

Du R, Jiang F, Wang ZY, Kang YQ, Wang XY, Du Y. Pure Large-cell neuroendocrine carcinoma originating from the endometrium: A case report. World J Clin Cases 2021; 9(14): 3449-3457

2021-05-16 | Browse: 330 | Download: 48

Zhang YT, Liu J, Pan XB, Gao YD, Hu YF, Lin L, Cheng HJ, Chen GY. Successful treatment in infantile hepatitis B with lamivudine: A case report. World J Clin Cases 2021; 9(14): 3442-3448

2021-05-16 | Browse: 329 | Download: 47

Chooah O, Ding J, Fei JL, Xu FY, Yue T, Pu CL, Hu HJ. Radiological insights of ectopic thyroid at the porta hepatis: A case report and review of literature. World J Clin Cases 2021; 9(14): 3432-3441

2021-05-16 | Browse: 370 | Download: 43

Inoue H, Ochiai T, Kubo H, Yamamoto Y, Morimura R, Ikoma H, Otsuji E. Laparoscopic cholecystectomy for gangrenous cholecystitis in around nineties: Two case reports. World J Clin Cases 2021; 9(14): 3424-3431

2021-05-16 | Browse: 343 | Download: 38

Meyer A, Carvalho BJ, Medeiros KA, Pipek LZ, Nascimento F, Suzuki M, Munhoz J, Iuamoto LR, Carneiro-D'Alburquerque LA, Andraus W. Change in neoadjuvant chemotherapy could alter the prognosis of patients with pancreatic adenocarcinoma: A case report. World J Clin Cases 2021; 9(14): 3418-3423

2021-05-16 | Browse: 419 | Download: 44

2021-05-16 | Browse: 316 | Download: 37

Zheng W, Yin QQ, Hui TC, Wu WH, Wu QQ, Huang HJ, Chen MJ, Yan R, Huang YC, Pan HY. Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of literature. World J Clin Cases 2021; 9(14): 3403-3410

2021-05-16 | Browse: 297 | Download: 36

Zhu JH, Li M, Liang Y, Wu JH. Tenosynovial giant cell tumors involving the cervical spine: A case report. World J Clin Cases 2021; 9(14): 3394-3402

2021-05-16 | Browse: 345 | Download: 42

Huette P, Abou Arab O, Jounieaux V, Guilbart M, Belhout M, Haye G, Dupont H, Beyls C, Mahjoub Y. Almitrine for COVID-19 critically ill patients – a vascular therapy for a pulmonary vascular disease: Three case reports. World J Clin Cases 2021; 9(14): 3385-3393

2021-05-16 | Browse: 338 | Download: 33

Lee HL, Fu CK. Acute cholangitis detected ectopic ampulla of Vater in the antrum incidentally: A case report. World J Clin Cases 2021; 9(14): 3379-3384

2021-05-16 | Browse: 296 | Download: 36

Huang GH, Tang JA, Yang TY, Liu Y. Floating elbow combining ipsilateral distal multiple segmental forearm fractures: A case report. World J Clin Cases 2021; 9(14): 3372-3378

2021-05-16 | Browse: 270 | Download: 34

Sun LJ, Li Y, Qiao W, Yu JH, Ren WD. Incremental value of three-dimensional and contrast echocardiography in the evaluation of endocardial fibroelastosis and multiple cardiovascular thrombi: A case report. World J Clin Cases 2021; 9(14): 3365-3371

2021-05-16 | Browse: 320 | Download: 40

Li J, Fang X, Yu FC, Du B. Recurrent perimesencephalic nonaneurysmal subarachnoid hemorrhage within a short period of time: A case report. World J Clin Cases 2021; 9(14): 3356-3364

2021-05-16 | Browse: 379 | Download: 35

Wu ZW, Sha Y, Chen Q, Hou J, Sun Y, Lu WK, Chen J, Yu LJ. Novel intergenic KIF5B-MET fusion variant in a patient with gastric cancer: A case report. World J Clin Cases 2021; 9(14): 3350-3355

2021-05-16 | Browse: 295 | Download: 32

Zhou W, Zhang WJ, Zhao GQ, Li K. Bone cement implantation syndrome during hip replacement in a patient with pemphigus and Parkinson’s disease: A case report. World J Clin Cases 2021; 9(14): 3342-3349

2021-05-16 | Browse: 324 | Download: 41

Song Q, Sun XF, Wu XL, Dong Y, Wang L. Skeletal muscle metastases of hepatocellular carcinoma: A case report and review of literature. World J Clin Cases 2021; 9(14): 3334-3341

2021-05-16 | Browse: 324 | Download: 42

43689 items Read more >>

Featured Articles

Alqahtani JS. Patient-ventilator asynchrony in Saudi Arabia: Where we stand? World J Crit Care Med 2021; 10(3): 58-60

2021-05-08 | Browse: 7 | Download: 0

Tahtabasi M, Hosbul T, Karaman E, Akin Y, Kilicaslan N, Gezer M, Sahiner F. Frequency of hepatic steatosis and its association with the pneumonia severity score on chest computed tomography in adult COVID-19 patients. World J Crit Care Med 2021; 10(3): 47-57

2021-05-08 | Browse: 5 | Download: 0

Pothiawala S, Yong CK, Charles R. Inhaling muscle spray: A rising trend of abuse. World J Crit Care Med 2021; 10(3): 43-46

2021-05-08 | Browse: 8 | Download: 4

Smirnov AA, Kiriltseva MM, Lyubchenko ME, Nazarov VD, Botina AV, Burakov AN, Lapin SV. Peroral endoscopic myotomy in a pregnant woman diagnosed with mitochondrial disease: A case report . World J Gastrointest Endosc 2021; 13(5): 155-160

2021-05-08 | Browse: 6 | Download: 0

2021-05-08 | Browse: 7 | Download: 0

2021-05-07 | Browse: 15 | Download: 21

Arslan ME, Li H, Fu Z, Jennings TA, Lee H. Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis. World J Gastrointest Oncol 2021; 13(5): 409-423

2021-05-07 | Browse: 11 | Download: 12

Matsuoka T, Yashiro M. Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. World J Gastrointest Oncol 2021; 13(5): 366-390

2021-05-07 | Browse: 10 | Download: 7

Rompianesi G, Di Martino M, Gordon-Weeks A, Montalti R, Troisi R. Liquid biopsy in cholangiocarcinoma: Current status and future perspectives. World J Gastrointest Oncol 2021; 13(5): 332-350

2021-05-07 | Browse: 13 | Download: 7

King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE. Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers. World J Gastrointest Oncol 2021; 13(5): 312-331

2021-05-07 | Browse: 9 | Download: 9

Di Ciaula A, Portincasa P. Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children: An ecologic study. World J Diabetes 2021; 12(5): 673-684

2021-05-06 | Browse: 13 | Download: 14

Michalakis K, Ilias I. COVID-19 and hyperglycemia/diabetes. World J Diabetes 2021; 12(5): 642-650

2021-05-06 | Browse: 18 | Download: 6

2021-05-06 | Browse: 18 | Download: 5

Sharma R, Tiwari S. Renal gluconeogenesis in insulin resistance: A culprit for hyperglycemia in diabetes. World J Diabetes 2021; 12(5): 556-568

2021-05-06 | Browse: 20 | Download: 5

Nasa P, Chaudhary S, Shrivastava PK, Singh A. Euglycemic diabetic ketoacidosis: A missed diagnosis. World J Diabetes 2021; 12(5): 514-523

2021-05-06 | Browse: 11 | Download: 2

Becker MW, Schwambach KH, Lunardelli M, Blatt CR. Overview of drug induced liver injury in Brazil: What is the role of public health policy on the evidence? World J Gastrointest Pharmacol Ther 2021; 12(3): 40-55

2021-04-30 | Browse: 25 | Download: 33

2021-04-29 | Browse: 46 | Download: 40

Kostopoulou E, Skiadopoulos S, Partsalaki I, Rojas Gil AP, Spiliotis BE. Repetitiveness of the oral glucose tolerance test in children and adolescents. World J Clin Pediatr 2021; 10(3): 29-39

2021-04-29 | Browse: 27 | Download: 56

4262 items Read more >>

Published Articles Processes

Alqahtani JS. Patient-ventilator asynchrony in Saudi Arabia: Where we stand? World J Crit Care Med 2021; 10(3): 58-60

2021-05-08 | Browse: 6 | Download: 0

2021-05-08 | Browse: 7 | Download: 0

Pothiawala S, Yong CK, Charles R. Inhaling muscle spray: A rising trend of abuse. World J Crit Care Med 2021; 10(3): 43-46

2021-05-08 | Browse: 8 | Download: 0

2021-05-08 | Browse: 9 | Download: 0

2021-05-08 | Browse: 6 | Download: 0

2021-05-08 | Browse: 8 | Download: 4

Bae JM. Sex as an effect modifier in the association between alcohol intake and gastric cancer risk. World J Gastrointest Oncol 2021; 13(5): 453-461

2021-05-07 | Browse: 8 | Download: 28

2021-05-07 | Browse: 11 | Download: 36

2021-05-07 | Browse: 8 | Download: 32

Arslan ME, Li H, Fu Z, Jennings TA, Lee H. Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis. World J Gastrointest Oncol 2021; 13(5): 409-423

2021-05-07 | Browse: 8 | Download: 22

McCaughan H, Boyle S, McGoran JJ. Update on the management of the gastrointestinal effects of radiation. World J Gastrointest Oncol 2021; 13(5): 400-408

2021-05-07 | Browse: 13 | Download: 24

Li C, Wang Q, Jiang KW. What is the best surgical procedure of transverse colon cancer? An evidence map and minireviews. World J Gastrointest Oncol 2021; 13(5): 391-399

2021-05-07 | Browse: 8 | Download: 24

Matsuoka T, Yashiro M. Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. World J Gastrointest Oncol 2021; 13(5): 366-390

2021-05-07 | Browse: 9 | Download: 26

2021-05-07 | Browse: 8 | Download: 24

Rompianesi G, Di Martino M, Gordon-Weeks A, Montalti R, Troisi R. Liquid biopsy in cholangiocarcinoma: Current status and future perspectives. World J Gastrointest Oncol 2021; 13(5): 332-350

2021-05-07 | Browse: 9 | Download: 26

King R, Hayes C, Donohoe CL, Dunne MR, Davern M, Donlon NE. Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers. World J Gastrointest Oncol 2021; 13(5): 312-331

2021-05-07 | Browse: 7 | Download: 22

Di Ciaula A, Portincasa P. Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children: An ecologic study. World J Diabetes 2021; 12(5): 673-684

2021-05-06 | Browse: 10 | Download: 16

Bódi N, Mezei D, Chakraborty P, Szalai Z, Barta BP, Balázs J, Rázga Z, Hermesz E, Bagyánszki M. Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia. World J Diabetes 2021; 12(5): 658-672

2021-05-06 | Browse: 13 | Download: 16

Umano GR, Di Sessa A, Guarino S, Gaudino G, Marzuillo P, Miraglia del Giudice E. Telemedicine in the COVID-19 era: Taking care of children with obesity and diabetes mellitus. World J Diabetes 2021; 12(5): 651-657

2021-05-06 | Browse: 11 | Download: 11

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Reader Comments

"This review focused on these blood, urine, and feces-based biomarkers including proteins, metabolites, circulating nucleic acids, ..." [Read more]

"This review focused on these blood, urine, and feces-based biomarkers including proteins, metabolites, circulating nucleic acids, circulating tumor cells, extracellular vesicles, and gut microbiota on clinical application of these biomarkers.It provided a better strategy for early clinical diagnosis of HCC,but some methods should be further studied and clarified." [Collapse]

" This manuscript provides a comprehensive review of the main anti-tumor targets based on molecular alterations in patients with ..." [Read more]

" This manuscript provides a comprehensive review of the main anti-tumor targets based on molecular alterations in patients with colorectal, esophageal and gastric cancer. In general, well written, and the information presented in the tables and figures is very complete. There is little discussion about the importance of these molecular targets in progression or response treatment. There are spelling errors in the text. For example, in the title -caner instead of cancer " [Collapse]

"This article discussed the feasibility of LB in patients with CCA, and provided the possibility for early diagnosis of CCA.The next ..." [Read more]

"This article discussed the feasibility of LB in patients with CCA, and provided the possibility for early diagnosis of CCA.The next step is to promote the development of clinical precision medicine." [Collapse]

"As the authors mentioned, AI is a breakthrough technology in recent medicine and is expected to play an active role in various fields, ..." [Read more]

"As the authors mentioned, AI is a breakthrough technology in recent medicine and is expected to play an active role in various fields, not only the colorectal cancer field. However, AI can provide the answer but not the process by which the answer was derived. Therefore, over-reliance on AI may hinder the improvement of the abilities and skills of physicians, especially beginners. AI is only a supplementary tool not a mainstay; thus, full reliance on AI should be avoided. Humans should provide the diagnosis of lesions and treatment of patients. If we understand this and adopt well with AI applications, AI can be a good adjunctive tool in various medical situations." [Collapse]

Alloro R, Sinagra E. Artificial intelligence and colorectal cancer: How far can you go? Artif Intell Cancer 2021; 2(2): 7-11 [DOI: 10.35713/aic.v2.i2.7]

"The theme of this paper is very interest. In a later article, the authors can further discuss the relationship between the ..." [Read more]

"The theme of this paper is very interest. In a later article, the authors can further discuss the relationship between the Hypoxia-induced ncRNAs and the tumour microenvironment of gastroesophageal cancers. " [Collapse]

"Overall this is a good read that provides concise yet informative article about Euglycemic DKA. With the wide use of SGLT ..." [Read more]

"Overall this is a good read that provides concise yet informative article about Euglycemic DKA. With the wide use of SGLT inhibitors as a first line of therapy of type-2 diabetes, more case reports are published reporting euglycemic DKA. The challenge as explained by the authors that this is condition that is traditionally diagnosed by exclusion. As such, many cases can be misdiagnosed and not treated properly. The article provides a good summary of the possible underlying causes of euglycemic DKA, discuss proper diagnosis and outlines the treatment. The authors concludes with the importance to educate patients with diabetes who are receiving SGLT inhibitors as part of their therapy. The provided table and diagram that summarized the risk factors and possible mechanisms are very helpful. I wished if the authors expanded the section on SGLT-inhibitors to include a separate section for type-1 diabetes and another section type-2 diabetes. Readers can get easily mixed up. It is important to stay alert that FDA did not approve the utilization of SGLT-inhibitors yet in patients with type-1 diabetes. Although, the risk of development of euglycemic DKA are way higher in type-1 diabetes, the majority of case reports are mainly associated with patients with type-2 diabetes. That distinction should have been made clear to the average reader. Thanks for providing this article to fill the gap in our readership about this important disease condition." [Collapse]

Nasa P, Chaudhary S, Shrivastava PK, Singh A. Euglycemic diabetic ketoacidosis: A missed diagnosis. World J Diabetes 2021; 12(5): 514-523 [DOI: 10.4239/wjd.v12.i5.514]

"I've read it and it is very intrigue."

Ríos-Ríos WJ, Sosa-Luis SA, Torres-Aguilar H. Current advances in using tolerogenic dendritic cells as a therapeutic alternative in the treatment of type 1 diabetes. World J Diabetes 2021; 12(5): 603-615 [DOI: 10.4239/wjd.v12.i5.603]

"This complex review highlights the importance of AI in diagnosis and management of IBD patients. Although clinical assessment by the ..." [Read more]

"This complex review highlights the importance of AI in diagnosis and management of IBD patients. Although clinical assessment by the gastroenterologist remains the gold atandard, AI and its applications could improve daily clinical practice after validation in large prospective studies." [Collapse]

"1. Could you please provide photos of uterine specimens? As far as I am concerned, most neuroendocrine carcinoma of the female ..." [Read more]

"1. Could you please provide photos of uterine specimens? As far as I am concerned, most neuroendocrine carcinoma of the female reproductive organs originate from the cervix. 2. Please describe the tumor markers in detail. 3. The final diagnosis stage is FIGO IIIc due to positive ascites cytology? 4.The article mentioned that the patient did not perform lymphadenectomy because of obesity, however, the cervical neuroendocrine carcinoma is prone to lymph node metastasis. Did the lymph node be explored during the operation? Please give the patient's BMI." [Collapse]

Du R, Jiang F, Wang ZY, Kang YQ, Wang XY, Du Y. Pure large cell neuroendocrine carcinoma originating from the endometrium: A case report. World J Clin Cases 2021; 9(14): 3449-3457 [DOI: 10.12998/wjcc.v9.i14.3449]

"We read with interest a retrospective cross-sectional study by Yang et al, who reviewed 266 patients with hepatitis B associated ..." [Read more]

"We read with interest a retrospective cross-sectional study by Yang et al, who reviewed 266 patients with hepatitis B associated cirrhosis receiving Nucleos(t)ide analogs (NAs) antiviral therapy and found that age ≥60 years, smoking history, family history of HBV-associated hepatocellular carcinoma (HCC), fasting blood glucose (FBG)≥6.16mmol/L, lamivudine(LAM) resistance and HBV DNA negativity are independent risk factors for progression to HCC in HBV-associated cirrhosis during antiviral therapy for NA. Although antiviral therapy inhibited HBV DNA synthesis, there was no significant reduction in the incidence of HCC. Widespread use of NA antiviral therapy has been shown in the study to significantly reduce liver disease mortality, but this may increase life expectancy and the risk of HCC, leading to an increased burden of HCC in HBV epidemic population. As treatment approaches evolve, it is important to understand the risk factors for patients to progress to HCC, even if they have been cured of chronic HBV infection. This is especially important for patients with cirrhosis, who are thought to be most likely to develop HCC. Therefore, these findings of Yang et al have a very important positive effect on reducing the incidence of HCC. Study shows obesity is associated with liver damage and further accelerate the development of HCC. In Yang's study, there was no data on the number of patients with fatty liver disease or BMI. It is reasonable to propose whether obesity is an independent risk factor for HCC in NA-treated patients with chronic hepatitis (CHB) associated cirrhosis, and we believe this important issue should be further investigated. Interestingly, Yang and his colleagues examined serum AFP levels in patients with progression to HCC. 65 patients with serum AFP<20μg/L had space occupation lesions and were diagnosed with HCC by MRI enhancement, histopathology, and liver DSA examination. Therefore, Yang et al suggest that serum AFP levels are of little value for early detection of HCC. AFP is the most used biomarker in HCC monitoring, but AFP is also elevated in some conditions, such as acute and chronic hepatitis, intrahepatic cholangiocarcinoma, and gonadal embryoma. So, its specificity is weakened, and AFP is not considered an ideal diagnostic biomarker for HCC. Although Yang et al have proved that AFP cannot be used for early monitoring of HCC in HBV-related cirrhosis patients receiving NA treatment, the problem of lacking biomarkers for monitoring HBV and early diagnosis of HCC still exists. Considerable efforts are currently devoted to identifying promising biomarkers for the diagnosis of HCC Research. Such as serum HBV RNA or hepatitis B core-related antigen (HBcrAg) for the monitoring of HBV activities, M2BPGi for predicting HCC occurrence in CHB patients with cirrhosis. However, the current data suggest that no single biomarker is likely to have the best sensitivity and specificity. In other words, extended explorations are needed in terms of early detection. It has been reported that with prolonged NA Treatment (Median Period 126 months), cccDNA can be significantly reduced. So, the value of Yang's study would be higher if the observations lasted longer. Besides, attention should be paid to the problem of drug resistance of NA. During the treatment of NA, drug resistance of patients needs to be detected in time, and additional or appropriate nucleoside (acid) analogs should be considered for continuous viral suppression. " [Collapse]

Yang DH, Wang WP, Zhang Q, Pan HY, Huang YC, Zhang JJ. Hepatocellular carcinoma progression in hepatitis B virus-related cirrhosis patients receiving nucleoside (acid) analogs therapy: A retrospective cross-sectional study. World J Gastroenterol 2021; 27(17): 2025-2038 [DOI: 10.3748/wjg.v27.i17.2025]

"The study is a well-designed, retrospective cross-sectional study with the outcome study were dependent and or independent variables ..." [Read more]

"The study is a well-designed, retrospective cross-sectional study with the outcome study were dependent and or independent variables that had a contributing on HCC progression on HBV-cirrhotic during AN-therapy. The AFP level may not be used as a marker of malignancy progression, but only for screening progression of the disease. this study results mentioning on Serum AFP has limited ability to diagnose HBV-related HCC." [Collapse]

"The manuscript is a review article. The main topic is about the possibility of metformin as an anti-metabolic syndrome that can use ..." [Read more]

"The manuscript is a review article. The main topic is about the possibility of metformin as an anti-metabolic syndrome that can use as a treatment choice for GI cancer as a high light for next research. So, I think this review is very interesting and can promote a new perspective in the therapeutic era in GI cancer. " [Collapse]

Cunha Júnior AD, Bragagnoli AC, Costa FO, Carvalheira JBC. Repurposing metformin for the treatment of gastrointestinal cancer. World J Gastroenterol 2021; 27(17): 1883-1904 [DOI: 10.3748/wjg.v27.i17.1883]

"The mini review of a meaningful study for daily practice of polypectomy, ESD and EMR. I suggest to accpeted "

Sbeit W, Khoury T, Mari A. Diagnostic approach to faecal incontinence: What test and when to perform? World J Gastroenterol 2021; 27(15): 1553-1562 [PMID: 33958842 DOI: 10.3748/wjg.v27.i15.1553]

"The paper is concise, well-written, without spelling or grammar errors. The scientific value of this article would have been even ..." [Read more]

"The paper is concise, well-written, without spelling or grammar errors. The scientific value of this article would have been even greater with a prospective study." [Collapse]

"the paper is overall good but need some changes to make it presentable"

Ip WY, Yeung FK, Yung SPF, Yu HCJ, So TH, Vardhanabhuti V. Current landscape and potential future applications of artificial intelligence in medical physics and radiotherapy. Artif Intell Med Imaging 2021; 2(2): 37-55 [DOI: 10.35711/aimi.v2.i2.37]

"The sentences are repeated in the abstract and the introduction. It is suggested that the same thing can be explained in different ..." [Read more]

"The sentences are repeated in the abstract and the introduction. It is suggested that the same thing can be explained in different way / rephrase the text. Too much text has been used in the tables, usually tabulated results are precise. Different font types are used in the article. The structure of the article is not appealing. " [Collapse]

Yakar M, Etiz D. Artificial intelligence in radiation oncology. Artif Intell Med Imaging 2021; 2(2): 13-31 [DOI: 10.35711/aimi.v2.i2.13]

"SARS-CoV-2 infection in people with pre-existing liver disease: Further research is warranted Henu Kumar Verma1* and Bhaskar ..." [Read more]

"SARS-CoV-2 infection in people with pre-existing liver disease: Further research is warranted Henu Kumar Verma1* and Bhaskar L.V.K.S. 1. Developmental and Stem Cell Biology Lab, Institute of Experimental Endocrinology and Oncology CNR, Naples, Italy Email: henu.verma@yahoo.com 2. Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India. Email: lvksbhaskar@gmail.com Conﬂicts of Interest: The authors declare no conﬂict of interest. *Corresponding Author Dr. Henu Kumar Verma Researcher Institute of Experimental Endocrinology and Oncology CNR, Naples, Italy Mobile: +91 9770476810/ +39 3922185508 http://orcid.org/0000-0003-1130-8783 Email: henu.verma@yahoo.com henu.verma@ieos.cnr.it A Commentary on “Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges.” Dear Editor Recently we have seen a paper entitled “Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges” contributed by Ali et al. in your well-regarded journal “World J Gastroenterol” [1]. Regarding this paper, we would like to draw your attention to several valuable and interesting aspects. The current scenario is that the second wave of the SARS-CoV-2 (COVID-19) pandemic is much more aggressive, with many more cases reported in various countries. As of April 2021, nearly 2.5-million deaths worldwide have been attributed to COVID-19. Based on the geographical distribution of the COVID-19 pandemic, it was found that in areas with a higher frequency, such as China, the rate of SARS-CoV-2 infected patients with liver impairment is also higher [2]. Most COVID-19 hospitalized patients have elevated liver biomarkers, primarily aminotransferase and bilirubin, which cause multi-organ failure [3, 4]. A recent review paper published in World J Gastroenterol by Ali et al. [1] shows great public health interest. In their article authors elegantly described the impact of SARS-CoV-2 on hepatic impairment conditions. Besides, they focused on several current studies that indicated the role of a hyperinflammatory state known as “cytokine storm” concerning the ACE2 receptor as the main factor for the high rate of SARS‐CoV‐2 spreading and mortality and its putative therapies [5]. The SARS-CoV-2 directly enters the host cell through surface receptors and binds to angiotensin-converting enzyme 2 (ACE2) [6]. Accumulating evidence indicated that the hepatic sharing of ACE2 after virus entry into the host cell. The underlying mechanisms of liver injury in COVID-19 patients are currently indistinguishable. RNAseq data from the human liver protein database shown that ACE2 was overexpressed in COVID19 patients. This analysis revealed a 59.7 % increase in ACE2 expression in cholangiocytes as compared to 2.6 % in hepatocytes, indicating that SARS-CoV-2 may directly bind to the ACE2 receptor and the liver may be a good host for SARS-CoV-2 [7, 8]. Histological analysis of liver biopsies of COVID-19 patients revealed moderate microvascular steatosis, mild lobular, portal activity, and T cell overexpression showing the liver injury could have been caused by either SARS-CoV-2 infection or treatment [3, 9]. A hospital-based study in China revealed elevated levels of proinflammatory cytokines, chemokines, and growth factors in COVID-19 patients compared to healthy adults [10, 11]. Further, the patients with severe COVID-19 show hepatic dysfunction or liver disorders, including chronic liver disease (CLD), hepatitis viruses [types B, C, D, and E], hepatotropic virus infection, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis with elevated platelets, neutrophils, and lymphocytes counts, resulting in the worst outcomes from Acute respiratory distress syndrome [12, 13]. There is no consensus among researchers regarding liver damage in COVID-19 patients; some studies proposed immediate cytopathic effect of the virus on hepatocytes or biliary epithelium via ACE receptors [14, 15] and others postulated inflammatory and immune-mediated liver failure in patients with multiple-organ damage [16]. However, hepatic inflammation involving cytokine activation was well-documented. A case study of COVID-19 patients demonstrated that the CRP of 20 mg/L and a lymphocyte count of 1.1 109/L were independent risk factors for liver injury [17]. The liver contains Kupffer cells, which have a high number of macrophages in the body and are cytokine producers. According to one study in Non-Alcoholic Fatty Liver Disease (NAFLD) patients, the macrophagic state's polarisation is altered, which has been linked to increased inflammatory cytokines response to SARS-CoV-2 [16]. Regardless of the precise definition, combinations of clinical manifestation and inflammatory markers (elevated plasma levels of CRP, LDH, IL-6, IL-1, TNF-α, and ferritin) could be used to define the “cytokine storm syndrome” COVID-19 patients [18-20]. Treatment with anti-IL-6 receptor monoclonal antibodies (sarilumab and tocilizumab), anti-IL-6 monoclonal antibodies (siltuximab), interleukin-1 (IL-1) Inhibitors (Anakinra, Rilonacept, and Canakinumab) and tumour necrosis factor-alpha (TNF α) inhibitors (adalimumab, etanercept and infliximab) showed promising results against SARS-CoV-2-induced cytokine storm [21-23]. In addition, corticosteroids that are known to alter the NF-kB pathway which is central to the cytokine storm were used in managing the severe SARS and MERS patients [24]. As cytokine storm is a critical life-threatening condition and has prognostic and therapeutic implications, the clinicians must recognize cytokine storm earlier to avoid intensive care admission and multi-organ damage. Reference: 1. Ali FEM, M.Z., Ali MM, Ghogar OM., Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. World J Gastroenterol, 2021. 27(15): p. 1531-1552. 2. Feng, G., et al., COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies. J Clin Transl Hepatol, 2020. 8(1): p. 18-24. 3. Sun, J., et al., COVID-19 and liver disease. Liver Int, 2020. 40(6): p. 1278-1281. 4. Zhang, C., L. Shi, and F.S. Wang, Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol, 2020. 5(5): p. 428-430. 5. Yongzhi, X., COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue. Emerg Microbes Infect, 2021. 10(1): p. 266-276. 6. Krishnamurthy, S., R.F. Lockey, and N. Kolliputi, Soluble ACE2 as a potential therapy for COVID-19. American Journal of Physiology-Cell Physiology, 2021. 320(3): p. C279-C281. 7. Lindskog, C., The potential clinical impact of the tissue-based map of the human proteome. Expert Rev Proteomics, 2015. 12(3): p. 213-5. 8. Chai, X., et al., Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection. bioRxiv, 2020: p. 2020.02.03.931766. 9. Ji, D., et al., Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study. J Hepatol, 2020. 73(2): p. 451-453. 10. Huang, C., et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 2020. 395(10223): p. 497-506. 11. Li, J., et al., Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China. Virus Res, 2020. 286: p. 198043. 12. Tian, D. and Q. Ye, Hepatic complications of COVID-19 and its treatment. J Med Virol, 2020. 92(10): p. 1818-1824. 13. Kudaravalli, P., et al., Case series and review of liver dysfunction in COVID-19 patients. Eur J Gastroenterol Hepatol, 2020. 32(9): p. 1244-1250. 14. Roedl, K., et al., Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect? Ann Intensive Care, 2021. 11(1): p. 44. 15. Huang, C., et al., Molecular and cellular mechanisms of liver dysfunction in COVID-19. Discov Med, 2020. 30(160): p. 107-112. 16. Xu, Z., et al., Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med, 2020. 8(4): p. 420-422. 17. Li, L., et al., Risk factors related to hepatic injury in patients with corona virus disease 2019. medRxiv, 2020: p. 2020.02.28.20028514. 18. Chen, G., et al., Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest, 2020. 130(5): p. 2620-2629. 19. Qin, C., et al., Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis, 2020. 71(15): p. 762-768. 20. Verma, H.K., Radiological and clinical spectrum of COVID-19: A major concern for public health. World J Radiol, 2021. 13(3): p. 53-63. 21. Atal, S. and Z. Fatima, IL-6 Inhibitors in the Treatment of Serious COVID-19: A Promising Therapy? Pharmaceutical medicine, 2020. 34(4): p. 223-231. 22. Sarzi-Puttini, P., et al., COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome? Clin Exp Rheumatol, 2020. 38(2): p. 337-342. 23. Rizk, J.G., et al., Pharmaco-Immunomodulatory Therapy in COVID-19. Drugs, 2020. 80(13): p. 1267-1292. 24. Tang, Y., et al., Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies. Front Immunol, 2020. 11: p. 1708. " [Collapse]

Ali FEM, Mohammedsaleh ZM, Ali MM, Ghogar OM. Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges. World J Gastroenterol 2021; 27(15): 1531-1552 [PMID: 33958841 DOI: 10.3748/wjg.v27.i15.1531]

"The application of AI in radiation oncology is very important."

Yakar M, Etiz D. Artificial intelligence in radiation oncology. Artif Intell Med Imaging 2021; 2(2): 13-31 [DOI: 10.35711/aimi.v2.i2.13]

"Which manufacturers of artificial intelligence systems did you evaluate ?There are not enough endoscopic images of polyps and tumors ..." [Read more]

"Which manufacturers of artificial intelligence systems did you evaluate ?There are not enough endoscopic images of polyps and tumors detected by the artificial intelligence system." [Collapse]

Alloro R, Sinagra E. Artificial intelligence and colorectal cancer: How far can you go? Artif Intell Cancer 2021; 2(2): 7-11 [DOI: 10.35713/aic.v2.i2.7]

"This topic is of great interest, and deemed to be furtherly investigated during a long period. However, the authors have not outlined ..." [Read more]

"This topic is of great interest, and deemed to be furtherly investigated during a long period. However, the authors have not outlined and described it as a sense and right way. AI, sometimes, can resolve the difficulties other advanced technologies or human could not do. Thus in this review authors should throw great effort to describe and clear what and how AI does process the images, by recognizing the diversity of the graphic grayscale, special molecules, or even some metal ions, which will distingusih the targets from surroundings." [Collapse]

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