Baishideng Publishing Group

Serenari M, Neri J, Marasco G, Larotonda C, Cappelli A, Ravaioli M, Mosconi C, Golfieri R, Cescon M. Two-stage hepatectomy with radioembolization for bilateral colorectal liver metastases: A case report. World J Hepatol 2021; 13(2): 261-269

"Thanks for your evaluation survey. I think that some requirement for submitting the manuscript, such as Non-native English editing and biostatistics certificates, should be optional!"

Hedayati-Moghaddam MR, Soltanian H, Ahmadi-Ghezeldasht S. Occult hepatitis C virus infection in the Middle East and Eastern Mediterranean countries: A systematic review and meta-analysis. World J Hepatol 2021; 13(2): 242-260

"We are very satisfied with WJG"

Jiang WT, Yang J, Xie Y, Guo QJ, Tian DZ, Li JJ, Shen ZY. Simultaneous partial splenectomy during liver transplantation for advanced cirrhosis patients combined with severe splenomegaly and hypersplenism. World J Gastroenterol 2021; 27(7): 654-665

"The present article contains both antiviral and pharmacological aspects of entecavir, the manuscript should be reviewed by the editors and reviewers with expertise in the subject area for this manuscript. However, there are very few peer reviewers who have profound knowledge of hepatitis B treatment and pharmacology. During the publication process, the editors made great efforts to find suitable peer reviewers, which led to the publication of this article. I sincerely thank the editors for their efforts."

Yin GQ, Li J, Zhong B, Yang YF, Wang MR. New therapeutic options for persistent low-level viremia in patients with chronic hepatitis B virus infection: Increase of entecavir dosage. World J Gastroenterol 2021; 27(8): 666-676

"This is a very pleasant submission process. BPG is a professional publishing company with a fast review cycle, constructive opinions, serious and responsible editors, and an open and transparent publishing process."

Huang YC, Yang NN, Chen HC, Huang YL, Yan WT, Yang RX, Li N, Zhang S, Yang PP, Feng ZZ. Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients. World J Gastroenterol 2021; 27(7): 624-640

"I on behalf of myself and my co-authors would like to thank the team at World Journal of Radiology"

Kochhar AS, Sidhu MS, Bhasin R, Kochhar GK, Dadlani H, Sandhu J, Virk B. Cone beam computed tomographic evaluation of pharyngeal airway in North Indian children with different skeletal patterns. World J Radiol 2021; 13(2): 40-52

"The publishing rule should be more clear for the authors. Big change or update need to inform the authors."

Yang M, Zhang CY. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. World J Gastroenterol 2021; 27(8): 677-691

"The authors express their sincere gratitude to the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and electronic editor for the high-quality and prompt execution of the work."

Zhao JD, Li Y, Sun M, Yu CJ, Li JY, Wang SH, Yang D, Guo CL, Du X, Zhang WJ, Cheng RD, Diao XC, Fang ZH. Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats. World J Gastroenterol 2021; 27(8): 708-724

"We are satisfied with most of the process, especially your rapid response. You all have answered our question as soon as possible. Thank you for your kind process of the publication."

Cho SY, Cho E, Park CH, Kim HJ, Koo JY. Septic shock due to Granulicatella adiacens after endoscopic ultrasound-guided biopsy of a splenic mass: A case report. World J Gastroenterol 2021; 27(8): 751-759

"GOOD!"

Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ. Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis. World J Stem Cells 2020; 12(11): 1396-1409

"It was a great publishing experience."

Ma L, Li X. Meeting report of the editorial board meeting for World Journal of Hepatology 2021. World J Hepatol 2021; 13(2): 162-165

"-"

Zhang H, Zhu YQ, Wu YQ, Zhang P, Qi J. Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer. World J Gastroenterol 2014; 20(20): 6329-6335

"Dear editor: Please make correction like below. On the online full-text article, in Introduction section, line 2, Please delete "-" from "...liver transplant-ation[1,2]. ... " to "...liver transplantation[1,2]. ..." Thanks."

Kanda T, Sasaki R, Masuzaki R, Moriyama M. Artificial intelligence and machine learning could support drug development for hepatitis A virus internal ribosomal entry sites. Artif Intell Gastroenterol 2021; 2(1): 1-9

"We would like to thank BPG for accepting and improving our manuscript! Much appreciated."

Lana JFSD, da Fonseca LF, Macedo RDR, Mosaner T, Murrell W, Kumar A, Purita J, de Andrade MAP. Platelet-rich plasma vs bone marrow aspirate concentrate: An overview of mechanisms of action and orthobiologic synergistic effects. World J Stem Cells 2021; 13(2): 155-167

"Thank you for editors and reviewers' support for our manuscript."

Zhu HS, Li D, Li C, Huang JX, Chen SS, Li LB, Shi Q, Ju XL. Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion. World J Stem Cells 2021; 13(2): 177-192

"Thanks for your professional and effective work."

Chen C, Huang XL, Gao DQ, Li YW, Qian SX. Chronic myelomonocytic leukemia-associated pulmonary alveolar proteinosis: A case report and review of literature. World J Clin Cases 2021; 9(5): 1156-1167

"It's always a pleasure to work with BPG. We are very thankfull for the oportunity."

Sampaio MM, Santos MLC, Marques HS, Gonçalves VLS, Araújo GRL, Lopes LW, Apolonio JS, Silva CS, Santos LKS, Cuzzuol BR, Guimarães QES, Santos MN, de Brito BB, da Silva FAF, Oliveira MV, Souza CL, de Melo FF. Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs: A literature review. World J Clin Oncol 2021; 12(2): 69-94

"None"

Manfredi C, Fernández-Pascual E, Linares-Espinós E, Couñago F, Martínez-Salamanca JI. New frontiers in focal therapy for prostate cancer: Prostate-specific membrane antigen positron emission tomography/magnetic resonance imaging. World J Clin Oncol 2021; 12(2): 61-68

"None"

López-Campos F, González-San Segundo C, Conde-Moreno AJ, Couñago F. Metastatic hormone-sensitive prostate cancer: How should it be treated? World J Clin Oncol 2021; 12(2): 43-49

"None"

Zhan GF, Wang Y, Yang N, Luo AL, Li SY. Digestive system involvement of infections with SARS-CoV-2 and other coronaviruses: Clinical manifestations and potential mechanisms. World J Gastroenterol 2021; 27(7): 561-575

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Article Quality Tracking-Peer-Review

"Tnank you for the manuscript. It is very inteesting and usefull"

"This article is interesting, group of patiets id large enough. Statistical analysis is very good. The method is new a interesting."

"I think this is a case report on neonatal systemic infection with Stenotrophomas maltophilia. I think the authors reported clincal information of thee case in detail. However, the lesson from these cases and the message of the article is unclear to me. Because it seems these cases underscore the importance of antibiogram and sensitivity tests."

Behera B. Stenotrophomonas maltophilia, an emerging pathogen in newborns: Three case reports and a review of the literature. World J Clin Infect Dis 2021; 11(1): 11-18

"Congratulations of finishing the tough task of reviewing literature. The few things I would like to highlight to bring into your notice. 1) There are minor language concerns, like for months or monthly, inappropriate abbreviations are used like 'mo' and 'moly'. 2) The flow of articles finally reviewed, the given table and text, gives ambiguous impression. As it says in text that total 117 paper and additional 7 papers found and after screening 37 +7=44, which were screened and 11 excluded (what was reason for this exclusion), and how many duplicate entries were removed? As exclusion of 23 papers finally is well mentioned, but not for other excluded papers. Kindly make it more comprehensible. 3) Conclusion is heavy in words, strays from article title, as such no primary or secondary goals of review are defined. Reading conclusion makes it little dull, can be made crisp and interesting. Apart from that, I think article is fairly structured, well reviewed and good work. Thank you. "

Hennessy O, Egan L, Joyce M. Subtotal colectomy in ulcerative colitis—long term considerations for the rectal stump. World J Gastrointest Surg 2021; 13(2): 198-209

"This is an interesting review by Yang and Zhang (MN 60749), summarizing current thoughts on the development and progression of nonalcoholic fatty liver disease (NAFLD), and the potential pathogenic role of G protein-coupled receptors (GPCRs). With this review, the authors offer an updated view on the role of GPCRs in the regulation of nutrient metabolism, and its potential effects on NAFLD development and progression. GPCR-mediated signaling and its association with lipid synthesis, lipid and glucose metabolism, and production of extracellular matrix (ECM) proteins, are discussed in the context of liver metabolism. The text is clear and well structured, and the manuscript contains figures and tables of good quality and informative. The article refers to the most important and the latest references in the field, reflecting the accuracy and rigorousness of the authors. The chosen subject is original, and presents interesting thoughts that could prove helpful for future advances in the field of NAFLD, concerning mechanisms of disease and new therapeutic targets. In addition to introducing the therapeutic potential of GPCR-mediated signaling in liver disease, the review presents information on ongoing related preclinical and clinical trials. "

Yang M, Zhang CY. G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment. World J Gastroenterol 2021; 27(8): 677-691

"A case report highlighting the importance of multi pronged management of advanced malignancies. "

"This paper is methodologically wrong. The definition of occult HCV is inaccurately given. Occult hepatitis C virus (HCV) infection (OCI), first described in 2004, is defined as the presence of HCV RNA in hepatocytes or peripheral blood mononuclear cells without detectable HCV RNA in the serum. https://pubmed.ncbi.nlm.nih.gov/29951360/"

"An important study on the knowledge gaps between specialists and generalists. This needs to be amplified and solutions for such are not adequately provided by the authors. "

Wessels DH, Rosenberg Z. Awareness of non-alcoholic steatohepatitis and treatment guidelines: What are physicians telling us? World J Hepatol 2021; 13(2): 233-241

"Without the use of biopsy confirmed liver histology the study has very little to offer. Both investigations offered - fibroscan and the serum markers are not validated enough to come to study conclusions as mentioned by authors. "

Martinez-Castillo M, Hernandez-Barragan A, Flores-Vasconcelos I, Galicia-Moreno M, Rosique-Oramas D, Perez-Hernandez JL, Higuera-De la Tijera F, Montalvo-Jave EE, Torre-Delgadillo A, Cordero-Perez P, Muñoz-Espinosa L, Kershenobich D, Gutierrez-Reyes G. Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients. World J Hepatol 2021; 13(2): 218-232

"An interesting prospect, but authors do not clarify the clinical translation. The samples included were very heterogenous and use of antifibrotic agents to confirm proof of concept was lacking. "

Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Massault PP, Scatton O, Vaillant JC, Morozov VA, Pol S, Lagaye S. Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs. World J Hepatol 2021; 13(2): 187-217

"thanks for the excullent Meeting report of World Journal of Hepatology"

Ma L, Li X. Meeting report of the editorial board meeting for World Journal of Hepatology 2021. World J Hepatol 2021; 13(2): 162-165

"The authors have presented an exhaustive review on an important and much neglected topic."

Tantau AI, Mandrutiu A, Pop A, Zaharie RD, Crisan D, Preda CM, Tantau M, Mercea V. Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies. World J Hepatol 2021; 13(2): 166-186

"No comments."

Ma L, Li X. Meeting report of the editorial board meeting for World Journal of Hepatology 2021. World J Hepatol 2021; 13(2): 162-165

"1,The two CT images are not on the same level, so it is difficult to compare whether the tumor in the left liver has been reduced. 2, Liver metastasis of colon cancer can be resected locally, and for liver resection without liver disease basis, FLR/TFLV greater than 35% in enough."

"This review by Kanda and colleagues deals with the important issue of artificial intelligence for the development of antiviral drugs for hepatitis A virus (HAV) infection. Artificial intelligence, including machine learning and deep learning, is a promising field in the process of drug discovery in general. The authors present data on potential drug targets for HAV and suggest the potential role of AI in drug development for this virus. My two main objections relate to the content and structure of the manuscript. The authors could probable structure differently the manuscript: Present initially some data on the implementation of artificial intelligence for the development of drugs in hepatitis B and hepatitis C virus infection and not general on diagnosis and treatment of those viruses. And subsequently present detailed data on the virology of HAV and stress on possible viral targets that could be used for treatment for the future. "

"The work is very interesting and well prepared."

"Good novelty. However, the price for OTCS is high which limits the utliztion in clinical practise."

Guo JT, Zhang JJ, Wu YF, Liao Y, Wang YD, Zhang BZ, Wang S, Sun SY. Endoscopic full-thickness resection using an over-the-scope device: A prospective study. World J Gastroenterol 2021; 27(8): 725-736

"I strongly appreciate the approach in describing what is currently known regarding the ortobiologics effect in degenerative MSK diseases at molecular level as well as giving a rationale for combining some of them for enhanced effect. Even though the title of the article is a little bit misleading (as not only PRP is described but as well BMAC and its combination with PRP) I find this paper very useful for both clinicians and dresearchers "

"The authors studied the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C (CHC). This study was a prospective, cross-sectional, multicenter study. CHC patients were categorized in fibrosis grades through FibroTest®and/or FibroScan® and they measured Serum MMP-2, -7, and -9 by western blot and multiplex suspension array assays. Collagenolytic and gelatinase activity was determined through the Azocoll substrate and zymogram test, whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot assays. The qualitative variables were analyzed using the chi-square test, and the continuous parameters were analyzed using the Mann-Whitney U test. They used GraphPad Prism Software V6 for statistics. They found that high concentrations of inactive MMPs were present in the serum of CHC patients, reflecting the impossibility to restrain liver fibrosis progression. MMPs could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC. This manuscript was written well, they presented results in organized manner and the methods were also effective. Overall, this manuscript will provide information about role of MMPs in liver fibrosis progression of chronic hepatitis C patients. But there is no new information and the role of MMPs in liver fibrosis of HCV patients has already been reported. Moreover, HCV cure is well established. "

"Thank you for submitting your work with World journal of Gastrointestinal Surgery. It was quite interesting to read this article, as personally I feel 'fistula in ano' is a understated problem and what makes is more complex is recurrence rates after all sort of various treatment options available. As a pilot study it is good effort from your team, is the concept of pleurodesis the inspiration behind this? As two are different tissue lines, of course, however idea seems to be working. I appreciate the methodology, statistical tests applied, language and references, where I do not think any issues are there. However, I wonder how the patients were convinced for this new method of treatment while there are so many other options already there, were they informed about all other options, and in spite of that, was there any patient who refused or chose other options? Another critical area is why to combine inflammatory and non-inflammatory disease together? As both behave differently, as it will be common sense to assume the safety of this approach, yet, in IBD attempting this versus using medical management, answer needs to be explored with further studies. Thank you very much."

Villiger R, Cabalzar-Wondberg D, Zeller D, Frei P, Biedermann L, Schneider C, Scharl M, Rogler G, Turina M, Rickenbacher A, Misselwitz B. Perianal fistulodesis – A pilot study of a novel minimally invasive surgical and medical approach for closure of perianal fistulae. World J Gastrointest Surg 2021; 13(2): 187-197

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Peer-Reviewers and Manuscript Statistics