Baishideng Publishing Group

Berry CA. Nuances of oblique lumbar interbody fusion at L5-S1: Three case reports. World J Orthop 2021; 12(6): 445-455 [DOI: 10.5312/wjo.v12.i6.445]

"The whole process from submission to publication online of the manuscript is satisfied basically."

Jin CB, Yang L. Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases. World J Clin Cases 2021; 9(18): 4617-4626 [DOI: 10.12998/wjcc.v9.i18.4617]

"Nill"

Liu P, Liu Y, Ke CN, Li WS, Liu YM, Xu S. Therapeutic effect of autologous concentrated growth factor on lower-extremity chronic refractory wounds: A case report. World J Clin Cases 2021; 9(18): 4797-4802 [DOI: 10.12998/wjcc.v9.i18.4797]

"The peer review process was slow and the feedback could have been more helpful. Although the issues with the publication fee were ..." [Read more]

"The peer review process was slow and the feedback could have been more helpful. Although the issues with the publication fee were eventually addressed, it took a great deal of work on my part to rectify this error and it was VERY hard to get ahold of anyone at the publishing company." [Collapse]

Michaels TI, Stone E, Singal S, Novakovic V, Barkin RL, Barkin S. Brain reward circuitry: The overlapping neurobiology of trauma and substance use disorders. World J Psychiatr 2021; 11(6): 222-231 [DOI: 10.5498/wjp.v11.i6.222]

"There was considerable delay between the 1st acceptance of the Ms (Dec 2020) and the initial re-submission with editorial changes ..." [Read more]

"There was considerable delay between the 1st acceptance of the Ms (Dec 2020) and the initial re-submission with editorial changes requested (Jan - Feb 2021) - however the subsequent follow up to continue the process onto final Galley Proof and acceptance for publication took a further 4 months. Consequently, the article - which was the precedent part of the article submitted at the same time but published in March is now published in June and the delay seemed unusual. I am pleased with the overall process and the Journal. I do however feel that an ENDNOTE format for referencing and citation that can be downloaded and fit the required Journal criteria would be of great assistance to Authors - as currently a manual process is ultimately required. This would facilitate the existing automated Referencing by AI software used. I hope these constructive critiques may assist you. It is a good Journal with very broad and interesting topics. Thank you" [Collapse]

Gabel CP, Guy B, Mokhtarinia HR, Melloh M. Slacklining: A narrative review on the origins, neuromechanical models and therapeutic use. World J Orthop 2021; 12(6): 360-375 [DOI: 10.5312/wjo.v12.i6.360]

"Thank you for your consideration. We believe that this journal confirms its overall high quality level."

Di Sessa A, Lanzaro F, Zarrilli S, Picone V, Guarino S, Miraglia del Giudice E, Marzuillo P. COVID-19 and pediatric fatty liver disease: Is there interplay? World J Gastroenterol 2021; 27(22): 3064-3072 [DOI: 10.3748/wjg.v27.i22.3064]

"It was a very pleasant experience. The F6Publishing system is easy to use. Thanks to editors and reviewers."

An RP, Li DY, Xiang XL. Role of theories in school-based diabetes care interventions: A critical review. World J Clin Cases 2021; 9(18): 4709-4720 [DOI: 10.12998/wjcc.v9.i18.4709]

"I'm satisfied with the manuscript editing and publishing process."

Zicaro JP, Garcia-Mansilla I, Zuain A, Yacuzzi C, Costa-Paz M. Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament? Prospective comparative study. World J Orthop 2021; 12(6): 423-432 [DOI: 10.5312/wjo.v12.i6.423]

"This is a very good magazine. The reviewers and editors are very rigorous and serious, and I am very satisfied"

Wang Y, Hou ZJ, Wang HZ, Hu M, Li YX, Zhang Z. Comparison of ocular axis and corneal diameter between entropion and non-entropion eyes in children with congenital glaucoma. World J Clin Cases 2021; 9(18): 4637-4643 [DOI: 10.12998/wjcc.v9.i18.4637]

"The reviewers and the editors are all professional. Hope to publish other papers with you. Thanks."

Wu WY, Dong JJ, Huang XC, Chen ZJ, Chen XL, Dong QT, Bai YY. AWGS2019 vs EWGSOP2 for diagnosing sarcopenia to predict long-term prognosis in Chinese patients with gastric cancer after radical gastrectomy . World J Clin Cases 2021; 9(18): 4668-4680 [DOI: 10.12998/wjcc.v9.i18.4668]

"During the editorial process, some messages from BPG Editorial Office (editorialoffice@wjgnet.com), I did not recived directly in ..." [Read more]

"During the editorial process, some messages from BPG Editorial Office (editorialoffice@wjgnet.com), I did not recived directly in my hotmail account. Thanks." [Collapse]

Moran S, López-Sánchez M, Milke-García MDP, Rodríguez-Leal G. Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis. World J Gastroenterol 2021; 27(22): 3050-3063 [DOI: 10.3748/wjg.v27.i22.3050]

"Thanks. The process of publication was smooth."

Huang CT, Liang YJ. Anti-tumor effect of statin on pancreatic adenocarcinoma: From concept to precision medicine. World J Clin Cases 2021; 9(18): 4500-4505 [DOI: 10.12998/wjcc.v9.i18.4500]

"The overall review process seemed to have taken very long but once the manuscript was accepted, the process moved quickly. Please ..." [Read more]

"The overall review process seemed to have taken very long but once the manuscript was accepted, the process moved quickly. Please review the submission portal interface as the navigation is not streamlined. I was really satisfied with the Manuscript Operations feature, I think that is a wonderful way to keep the submitting author informed." [Collapse]

Schiller NC, Sama AJ, Spielman AF, Donnally III CJ, Schachner BI, Damodar DM, Dodson CC, Ciccotti MG. Trends in leadership at orthopaedic surgery sports medicine fellowships. World J Orthop 2021; 12(6): 412-422 [DOI: 10.5312/wjo.v12.i6.412]

"We are very satisfied with this submission. We appreciate the efforts of the assistant editor, science editor, peer reviewers, ..." [Read more]

"We are very satisfied with this submission. We appreciate the efforts of the assistant editor, science editor, peer reviewers, editorial director, journal editor-in-chief, company editor-in-chief, language editor and production editor." [Collapse]

Xie C, Shen YM, Chen QH, Bian C. Primary mesonephric adenocarcinoma of the fallopian tube: A case report. World J Clin Cases 2021; 9(18): 4741-4747 [DOI: 10.12998/wjcc.v9.i18.4741]

"It was a very pleasant experience."

Yang FC, Xu F, Wang TN, Chen GX. Roles of vitamin A in the regulation of fatty acid synthesis. World J Clin Cases 2021; 9(18): 4506-4519 [DOI: 10.12998/wjcc.v9.i18.4506]

"I think the better communication with the corresponding author and the handling editors may enhance the editorial ..." [Read more]

"I think the better communication with the corresponding author and the handling editors may enhance the editorial process. Thanks Dr. Ashktorab" [Collapse]

Mokarram P, Dalivand MM, Pizuorno A, Aligolighasemabadi F, Sadeghdoust M, Sadeghdoust E, Aduli F, Oskrochi G, Brim H, Ashktorab H. Clinical characteristics, gastrointestinal manifestations and outcomes of COVID-19 patients in Iran; does the location matters? World J Clin Cases 2021; 9(18): 4654-4667 [DOI: 10.12998/wjcc.v9.i18.4654]

"I found to get the paper published in WJG is a totally very new experience for me. I have to fill out numerous forms and make many ..." [Read more]

"I found to get the paper published in WJG is a totally very new experience for me. I have to fill out numerous forms and make many declarations, which weren’t that pleasant." [Collapse]

Jiang ZN, Ahmed SMU, Wang QC, Shi HF, Tang XW. Quinone oxidoreductase 1 is overexpressed in gastric cancer and associated with outcome of adjuvant chemotherapy and survival. World J Gastroenterol 2021; 27(22): 3085-3096 [DOI: 10.3748/wjg.v27.i22.3085]

"The overall process of submission and publication was very good. The only problem I found was that I frequently do not receive the ..." [Read more]

"The overall process of submission and publication was very good. The only problem I found was that I frequently do not receive the emails from the editorial office, and therefore some alerts go unnoticed, and my coauthors have to forward me the emails they receive." [Collapse]

Duque A, Mediano MFF, De Lorenzo A, Rodrigues Jr LF. Cardiovascular autonomic neuropathy in diabetes: Pathophysiology, clinical assessment and implications. World J Diabetes 2021; 12(6): 855-867 [DOI: 10.4239/wjd.v12.i6.855]

"Thank you for your support"

Valva P, Ríos DA, De Matteo E, Preciado MV. Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage. World J Gastroenterol 2016; 22(4): 1367-1381 [PMID: 26819506 DOI: 10.3748/wjg.v22.i4.1367]

"We are very much satisfied with the entire publication process. It has been a great pleasure working with the team of World Journal ..." [Read more]

"We are very much satisfied with the entire publication process. It has been a great pleasure working with the team of World Journal of Diabetes and we hope to do so again in the future. Thanks" [Collapse]

Palui R, Pramanik S, Mondal S, Ray S. Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus. World J Diabetes 2021; 12(6): 706-729 [DOI: 10.4239/wjd.v12.i6.706]

5921 items Read more >>

Article Quality Tracking-Peer-Review

"Since gastric cancer is an aggressive malignancy with a 5-year survival rate <40%, the topic is of interest. Gastric cancer is still ..." [Read more]

"Since gastric cancer is an aggressive malignancy with a 5-year survival rate <40%, the topic is of interest. Gastric cancer is still the sixth most common malignancy and remains the fourth leading cause of cancer-related deaths worldwide. Artificial intelligence (AI) has emerged in the gastric cancer field because of its potent efficient computational power and learning capacities in areas such as image-based diagnosis and prognosis prediction. AI-assisted diagnosis includes pathology, endoscopy, and computerized tomography and prognosis, including recurrence, metastasis, and survival prediction. Therefore, the authors' intention was good, and the paper was reasonably conceived and executed. However, the authors focused mainly on the AI intelligence applications in predicting Helicobacter pylori infection (Table 1; it should be pointed out that not all gastric cancers are Hp related) and AI applications in the prediction of invasion depth and differentiation of cancerous areas from noncancerous areas Table 2). Perhaps these were main reason why this paper was rated by the reviewers as C = good. The authors did not cite in the references a significant, excellent paper published in World J Gastroenterol. 2020 by Peng-Hui Niu – see below. Peng-Hui Niu, Lu-Lu Zhao, Hong-Liang Wu, Dong-Bing Zhao, and Ying-Tai Chen. Artificial intelligence in gastric cancer: Application and future perspectives. World J Gastroenterol. 2020 Sep 28; 26(36): 5408–5419. PMCID: PMC7520602 PMID: 33024393 The figures and tables are well designed. " [Collapse]

Hsiao YJ, Wen YC, Lai WY, Lin YY, Yang YP, Chien Y, Yarmishyn AA, Hwang DK, Lin TC, Chang YC, Lin TY, Chang KJ, Chiou SH, Jheng YC. Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer. World J Gastroenterol 2021; 27(22): 2979-2993 [DOI: 10.3748/wjg.v27.i22.2979]

"The article is devoted to the diagnosis and treatment of one of the most aggressive malignant tumors - pancreatic cancer (PC). The ..." [Read more]

"The article is devoted to the diagnosis and treatment of one of the most aggressive malignant tumors - pancreatic cancer (PC). The article discusses the issues of etiology, clinical manifestations, modern methods of diagnosis and treatment of PC. The authors discuss not only routine methods for diagnosing PC, but also the latest methods for visualizing the pathological process in an organ, such as "pancreatoscopy", "optical endomicroscopy", "intraductal ultrasound" (IDUS), the determination of the molecular profiling of tumors, and others. The article also discusses modern approaches to the treatment of PC. The criteria of resectability and protocols for the PC treatment presented in the article seem to be important, but it seems somewhat redundant that the authors cite the TNM classification of PC. Unfortunately, the authors practically do not touch upon the issues of prostate cancer screening, the criteria for identifying risk groups for which an in-depth study is required. Overall, the article is written in excellent English, relevant and up-to-date. The information contained in the article can be useful for clinicians involved in the diagnosis and treatment of prostate cancer. " [Collapse]

Zeeshan MS, Ramzan Z. Current controversies and advances in the management of pancreatic adenocarcinoma. World J Gastrointest Oncol 2021; 13(6): 472-494 [DOI: 10.4251/wjgo.v13.i6.472]

"A concisely written and well-structured manuscript, without spelling/grammar mistakes. The topic debated is of a great interest ..." [Read more]

"A concisely written and well-structured manuscript, without spelling/grammar mistakes. The topic debated is of a great interest especially for patients with CDI recurrences and not only. Recently, patients diagnosed with IBS and IBD can benefit from FMT, but we need complex and prospective studies in order to use this method in clinical practice with good results and with less side effects. Thank you." [Collapse]

El-Salhy M, Patcharatrakul T, Gonlachanvit S. Fecal microbiota transplantation for irritable bowel syndrome: An intervention for the 21^st century. World J Gastroenterol 2021; 27(22): 2921-2943 [DOI: 10.3748/wjg.v27.i22.2921]

"Oblique retroperitoneal access to L5-S1 in the lateral decubitus position is possible through three different approaches: ..." [Read more]

"Oblique retroperitoneal access to L5-S1 in the lateral decubitus position is possible through three different approaches: intra-bifurcation, left pre-psoas and right pre-psoas approaches. The authors stated that while the right-sided pre-psoas approach has been shown to be safe and feasible in some studies, they strongly advised gaining apprpriate experience prior to adopting this technique. They also mentioned that in early cases and in patients with challenging vascular anatomy, posterior alternatives may be considered. The problem is that the paper only include thre case reports." [Collapse]

Berry CA. Nuances of oblique lumbar interbody fusion at L5-S1: Three case reports. World J Orthop 2021; 12(6): 445-455 [DOI: 10.5312/wjo.v12.i6.445]

"Both arthroereisis (AR) procedures used for the treatment of juvenile flexible flatfoot, subtalar AR and calcaneo-stop (CS) ameliorated ..." [Read more]

"Both arthroereisis (AR) procedures used for the treatment of juvenile flexible flatfoot, subtalar AR and calcaneo-stop (CS) ameliorated clinical and radiological parameters. Considering the complications, calcaneo-stop screws had a slightly better rate than subtalar AR. The systematic review was really important because it demonstrated that both surgical techniques are effective." [Collapse]

Vescio A, Testa G, Amico M, Lizzio C, Sapienza M, Pavone P, Pavone V. Arthroereisis in juvenile flexible flatfoot: Which device should we implant? A systematic review of literature published in the last 5 years. World J Orthop 2021; 12(6): 433-444 [DOI: 10.5312/wjo.v12.i6.433]

"In this study 40 patients with partial tears of the anterior cruciate ligament experienced PRP injections. Overall, 67% of patients ..." [Read more]

"In this study 40 patients with partial tears of the anterior cruciate ligament experienced PRP injections. Overall, 67% of patients with this type of lesion return to sports in a mean of 4 months without clinical instability either with or without an intra-articular PRP injection. The addition of PRP alone was not sufficient to enhance any of the outcome measures evaluated, including MRI images and clinical evaluation. The series must be expanded to get enough statistical power to draw scientifically sound conclusions." [Collapse]

"According to the authors of this paper, now, the field of orthopaedics has lower percentages of females and minorities in leadership ..." [Read more]

"According to the authors of this paper, now, the field of orthopaedics has lower percentages of females and minorities in leadership roles. Therefore, I fully agree with them that gender and racial diversity of these specialties should be a continued focus. " [Collapse]

"The problem of this important paper is that it only inludes 23 patients affected with osteoarthritis or avascular necrosis. However, ..." [Read more]

"The problem of this important paper is that it only inludes 23 patients affected with osteoarthritis or avascular necrosis. However, they showed that cementless humeral head resurfacing (HHR) showed a good resul with a failure rate of 16% in a 7.4 year follow-up. Let me recommend the authors of this paper to expand their series." [Collapse]

Chillemi C, Paglialunga C, De Giorgi G, Proietti R, Carli S, Damo M. Outcome and revision rate of uncemented humeral head resurfacing: Mid-term follow-up study. World J Orthop 2021; 12(6): 403-411 [DOI: 10.5312/wjo.v12.i6.403]

"This paper compared with individuals in the general population with a matched comorbidity profile, patients with dermatomyositis and ..." [Read more]

"This paper compared with individuals in the general population with a matched comorbidity profile, patients with dermatomyositis and polymyositis who underwent primary THA. They foudn that such patients are at an augmented risk of potentially serious ninety-day complications (pneumonia and pulmonary embolism) and incur similar total costs following surgery. " [Collapse]

Rosas S, Schallmo M, Gowd AK, Akelman MR, Luo TD, Emory CL, Plate JF. Dermatomyositis and polymyositis in total hip arthroplasty. World J Orthop 2021; 12(6): 395-402 [DOI: 10.5312/wjo.v12.i6.395]

"These authors have reported that both corthopedic surgeons and patients with hip fracture must acknowledge the risks of COVID-19 as ..." [Read more]

"These authors have reported that both corthopedic surgeons and patients with hip fracture must acknowledge the risks of COVID-19 as part of a detailed informed consent process. These risks are lower respiratory tract infection, acute respiratory distress syndrome, deep vein thrombosis and pulmonary embolism, increased requirement for intensive care admission, longer inpatient stay and a higher risk of mortality" [Collapse]

Cuthbert R, Ferguson D, Kayani B, Haque S, Ali A, Parkar A, Bates P, Vemulapalli K. Evidence-based approach to providing informed consent for hip fracture surgery during the COVID-19 era. World J Orthop 2021; 12(6): 386-394 [DOI: 10.5312/wjo.v12.i6.386]

"These authors have mentioned that 3D printed cups produced using additive manufacturing demonstrated reliable clinical and radiographic ..." [Read more]

"These authors have mentioned that 3D printed cups produced using additive manufacturing demonstrated reliable clinical and radiographic mid-run results, even in large patient series. These implants also had a reliable safety profile. The metal ion levels and percentage of deep infection were comparable to control groups, and no cases of mechanical failure were found. Nevertheless, no clinical studies have shown significantly better outcomes when compared with conventional cups with the same bearing forces so far. Clinical trials and registry studies with longer follow-up are needed to confirm the theoretical benefits of 3D-printed cups in terms of osseointegration and a reduced percentage of aseptic loosening." [Collapse]

Castagnini F, Caternicchia F, Biondi F, Masetti C, Faldini C, Traina F. Off-the-shelf 3D printed titanium cups in primary total hip arthroplasty. World J Orthop 2021; 12(6): 376-385 [DOI: 10.5312/wjo.v12.i6.376]

"WThe authors of this paper have stated that understanding slacklining’s history and fundamentals has the potential for future broader ..." [Read more]

"WThe authors of this paper have stated that understanding slacklining’s history and fundamentals has the potential for future broader applications for functional movement, prosthesis, automation, and machine-learning. However, they should use slacklining in a series of patients to demonstrate that the method is really effective." [Collapse]

"The ERAS protocol developed by the authors for oncology patients who experience bone reconstruction surgeries using massive ..." [Read more]

"The ERAS protocol developed by the authors for oncology patients who experience bone reconstruction surgeries using massive endoprosthesis has the objective of ameliorating the surgical results. The idea is good but hey must use their protocol in a series of patients to prove that their protocol is really effective." [Collapse]

Bourazani M, Asimakopoulou E, Magklari C, Fyrfiris N, Tsirikas I, Diakoumis G, Kelesi M, Fasoi G, Kormas T, Lefaki G. Developing an enhanced recovery after surgery program for oncology patients who undergo hip or knee reconstruction surgery. World J Orthop 2021; 12(6): 346-359 [DOI: 10.5312/wjo.v12.i6.346]

"This retrospective study demonstrates that NQO1 overexpression is associated with a significantly worse prognosis and better response ..." [Read more]

"This retrospective study demonstrates that NQO1 overexpression is associated with a significantly worse prognosis and better response to 5-FU in patients with gastric cancer. It appears that the influence of INQ expression on improving therapeutic approaches in patients with gastric cancer is possible only by demonstrating these results in larger patient series. " [Collapse]

"This study demonstrates that a lower alb value at week two than week 0 in patients with ulcerative colitis on tacrolimus therapy may ..." [Read more]

"This study demonstrates that a lower alb value at week two than week 0 in patients with ulcerative colitis on tacrolimus therapy may predict clinical failure. However, as the author stated, this is a single-center study performed with few cases, and the data need to be supported by further studies." [Collapse]

Ishida N, Miyazu T, Tamura S, Tani S, Yamade M, Iwaizumi M, Hamaya Y, Osawa S, Furuta T, Sugimoto K. Early serum albumin changes in patients with ulcerative colitis treated with tacrolimus will predict clinical outcome. World J Gastroenterol 2021; 27(22): 3109-3120 [DOI: 10.3748/wjg.v27.i22.3109]

"This study illustrates findings that support the hypothesis that high fecal calprotectin levels among COVID-19 patients may lead to ..." [Read more]

"This study illustrates findings that support the hypothesis that high fecal calprotectin levels among COVID-19 patients may lead to intestinal inflammation and leaky gut syndrome by this virus. " [Collapse]

Zerbato V, Di Bella S, Giuffrè M, Jaracz AW, Gobbo Y, Luppino D, Macor P, Segat L, Koncan R, D'Agaro P, Valentini M, Crocé LS, Ruscio M, Luzzati R. High fecal calprotectin levels are associated with SARS-CoV-2 intestinal shedding in COVID-19 patients: A proof-of-concept study. World J Gastroenterol 2021; 27(22): 3130-3137 [DOI: 10.3748/wjg.v27.i22.3130]

"What is the incidence of transformation in a total of patients with EGFR-TKI treatment? How can we predict a patient with potential ..." [Read more]

"What is the incidence of transformation in a total of patients with EGFR-TKI treatment? How can we predict a patient with potential transformation activity?" [Collapse]

Jin CB, Yang L. Histological transformation of non-small cell lung cancer: Clinical analysis of nine cases. World J Clin Cases 2021; 9(18): 4617-4626 [DOI: 10.12998/wjcc.v9.i18.4617]

"This paper enlights the great results of El-Salhy paper and not the other 6 ones. It is not possible to compare these 7 trials because ..." [Read more]

"This paper enlights the great results of El-Salhy paper and not the other 6 ones. It is not possible to compare these 7 trials because of the different methodology used in each one. Also, the patient inclusion criteria does not inform which treatmets the patients had prior to be involved in the trials besides diet (antispasmodics, probiotics, antidepressants, etc). Neither explains wich treatments were the patients on after FMT. So it gives good information but I do not consider it complete. Although the graphics are very explicit and the author tried to explain the patophisiology of the good results." [Collapse]

"The review by Jang and Lee is original and comprehensive. The authors did a nice job summarizing the mechanisms involved in the ..." [Read more]

"The review by Jang and Lee is original and comprehensive. The authors did a nice job summarizing the mechanisms involved in the pathogenesis of insulin resistance due to gut bacterial metabolites." [Collapse]

Jang HR, Lee HY. Mechanisms linking gut microbial metabolites to insulin resistance. World J Diabetes 2021; 12(6): 730-744 [DOI: 10.4239/wjd.v12.i6.730]

"The review by Kuo and colleagues provides a perspective on the current and future application of OGTT in clinical practice and basic ..." [Read more]

"The review by Kuo and colleagues provides a perspective on the current and future application of OGTT in clinical practice and basic research. The topic is interesting. However, rather than focussing on basic research I would have expanded the discussion on the use of OGTT in clinical research, for example on OGTT-derived indexes of insulin sensitivity, and other potential applications in clinical practice (e.g., OGIS for predicting non-alcoholic fatty liver disease and non-alcoholic steatohepatitis). " [Collapse]

Kuo FY, Cheng KC, Li Y, Cheng JT. Oral glucose tolerance test in diabetes, the old method revisited. World J Diabetes 2021; 12(6): 786-793 [DOI: 10.4239/wjd.v12.i6.786]

6860 items Read more >>

Peer-Reviewers and Manuscript Statistics

Editorial board members: 3765

Peer-reviewers: 40981

Manuscripts received today: 10

Manuscript reviews today: 22

Unhandled manuscripts today: 115

Active peer-reviewers today: 363

Reviewer acceptance today: 41

Reviewer refusals today: 28

Total accepted manuscripts: 21130

Total rejected manuscripts: 26388

Total peer-reviewers: 681318

Total submissions: 18230

Baishideng Publishing Group (BPG) publishes 47 peer-reviewed, open-access journals covering a broad range of topics in clinical medicine, as well as several topics in biochemistry and molecular biology, relevant to human health today.

BPG Journals

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All Journal Articles

Zhang ZY, Zhang XA, Chen Q, Wang JY, Li Y, Wei ZY, Wang ZC. Listeria monocytogenes bacteremia in a centenarian and pathogen traceability: A case report. World J Clin Cases 2021; 9(18): 4873-4880

2021-06-26 | Browse: 69 | Download: 11

Wang GH, Shen HP, Chu ZM, Shen J. Adult rhabdomyosarcoma originating in the temporal muscle, invading the skull and meninges: A case report. World J Clin Cases 2021; 9(18): 4866-4872

2021-06-26 | Browse: 69 | Download: 12

Łącki S, Wyżgolik K, Nicze M, Georgiew-Nadziakiewicz S, Chudek J, Wdowiak K. Low symptomatic COVID-19 in the elderly patient with follicular lymphoma treated with rituximab-based immunotherapy: A case report. World J Clin Cases 2021; 9(18): 4859-4865

2021-06-26 | Browse: 116 | Download: 9

Ji W, Nie M, Mao JF, Zhang HB, Wang X, Wu XY. Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report. World J Clin Cases 2021; 9(18): 4852-4858

2021-06-26 | Browse: 72 | Download: 7

Zheng X, Sun QJ, Zhou B, Jin M, Yan S. Microscopic transduodenal excision of an ampullary adenoma: A case report and review of literature. World J Clin Cases 2021; 9(17): 4844-4851

2021-06-26 | Browse: 72 | Download: 5

Shi XY, Cai MT, Shen H, Zhang JX. Central pontine myelinolysis mimicking glioma in diabetes: A case report. World J Clin Cases 2021; 9(18): 4837-4843

2021-06-26 | Browse: 72 | Download: 9

Leão I, Marinho J, Costa T. Long-term response to avelumab and management of oligoprogression in Merkel cell carcinoma: A case report. World J Clin Cases 2021; 9(18): 4829-4836

2021-06-26 | Browse: 83 | Download: 12

Kim H, Kang MG, Park HW, Park JR, Hwang JY, Kim K. Anderson-Fabry disease presenting with atrial fibrillation as earlier sign in a young patient: A case report. World J Clin Cases 2021; 9(18): 4823-4828

2021-06-26 | Browse: 72 | Download: 13

Yu QW, Ye TF, Qian WJ. Rare coexistence of multiple manifestations secondary to thalamic hemorrhage: A case report. World J Clin Cases 2021; 9(18): 4817-4822

2021-06-26 | Browse: 92 | Download: 16

Wei ZJ, Zhu X, Yu HT, Liang ZJ, Gou X, Chen Y. Severe hematuria due to vesical varices in a patient with portal hypertension: A case report. World J Clin Cases 2021; 9(18): 4810-4816

2021-06-26 | Browse: 66 | Download: 14

Fan T, Zhang Y, Lv Y, Chang J, Bauer BA, Yang J, Wang CW. Cutaneous myiasis with eosinophilic pleural effusion: A case report. World J Clin Cases 2021; 9(18): 4803-4809

2021-06-26 | Browse: 64 | Download: 6

Liu P, Liu Y, Ke CN, Li WS, Liu YM, Xu S. Therapeutic effect of autologous concentrated growth factors on lower-extremity chronic refractory wounds: A case report. World J Clin Cases 2021; 9(18): 4797-4802

2021-06-26 | Browse: 62 | Download: 8

Zhao X, Zhang G, Li CH. Collision carcinoma of the rectum involving neuroendocrine carcinoma and adenocarcinoma: A case report. World J Clin Cases 2021; 9(18): 4789-4796

2021-06-26 | Browse: 60 | Download: 8

Nam DC, Hwang SC, Lee EC, Song MG, Yoo JI. Femoral neck stress fractures after trampoline exercise: A case report. World J Clin Cases 2021; 9(18): 4783-4788

2021-06-26 | Browse: 59 | Download: 3

Xue C, Chen Y, Gao YL, Zhang N, Wang Y. Disappeared intralenticular foreign body: A case report. World J Clin Cases 2021; 9(18): 4778-4782

2021-06-26 | Browse: 58 | Download: 5

Jiang HJ, Zhang Z, Zhang L, Pu YJ, Zhou N, Shu H. Neonatal syringocystadenoma papilliferum: A case report. World J Clin Cases 2021; 9(18): 4772-4777

2021-06-26 | Browse: 58 | Download: 4

Zhao CJ, Ma GZ, Wang YJ, Wang JH. Splenic Kaposi’s sarcoma in a human immunodeficiency virus-negative patient: A case report. World J Clin Cases 2021; 9(18): 4765-4771

2021-06-26 | Browse: 67 | Download: 5

Yang ZH, Hou FS, Yin YS, Zhao L, Liang X. Minimally invasive removal of a deep-positioned cannulated screw from the femoral neck: A case report. World J Clin Cases 2021; 9(18): 4760-4764

2021-06-26 | Browse: 88 | Download: 8

Zhao HY, Zhao YZ, Jia YM, Mei X, Guo SB. Pheochromocytoma with abdominal aortic aneurysm presenting as recurrent dyspnea, hemoptysis, and hypotension: A case report. World J Clin Cases 2021; 9(18): 4754-4759

2021-06-26 | Browse: 60 | Download: 2

Wu B, Chen SY, Li Y, He Y, Wang XX, Yang XJ. Pancreas-preserving duodenectomy of a duodenal papillary tumor: A case report. World J Clin Cases 2021; 9(18): 4748-4753

2021-06-26 | Browse: 72 | Download: 8

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Featured Articles

2021-06-11 | Browse: 7 | Download: 0

2021-06-11 | Browse: 6 | Download: 0

Castagnini F, Caternicchia F, Biondi F, Masetti C, Faldini C, Traina F. Off-the-shelf 3D printed titanium cups in primary total hip arthroplasty. World J Orthop 2021; 12(6): 376-385

2021-06-11 | Browse: 6 | Download: 0

Gabel CP, Guy B, Mokhtarinia HR, Melloh M. Slacklining: A narrative review on the origins, neuromechanical models and therapeutic use. World J Orthop 2021; 12(6): 360-375

2021-06-11 | Browse: 7 | Download: 0

2021-06-11 | Browse: 11 | Download: 7

Kerawala AA, Das B, Solangi A. Mesenteric ischemia in COVID-19 patients: A review of current literature. World J Clin Cases 2021; 9(18): 4700-4708

2021-06-11 | Browse: 11 | Download: 7

2021-06-11 | Browse: 10 | Download: 6

Taherkhani R, Taherkhani S, Farshadpour F. Dynamics of host immune responses to SARS-CoV-2. World J Clin Cases 2021; 9(18): 4480-4490

2021-06-11 | Browse: 8 | Download: 7

Kato H, Asano Y, Arakawa S, Ito M, Kawabe N, Shimura M, Hayashi C, Ochi T, Yasuoka H, Higashiguchi T, Kondo Y, Nagata H, Horiguchi A. Surgery for pancreatic tumors in the midst of COVID-19 pandemic. World J Clin Cases 2021; 9(18): 4460-4466

2021-06-11 | Browse: 5 | Download: 6

Michaels TI, Stone E, Singal S, Novakovic V, Barkin RL, Barkin S. Brain reward circuitry: The overlapping neurobiology of trauma and substance use disorders. World J Psychiatr 2021; 11(6): 222-231

2021-06-11 | Browse: 7 | Download: 0

Al-Jabi SW. Current global research landscape on COVID-19 and depressive disorders: Bibliometric and visualization analysis. World J Psychiatr 2021; 11(6): 253-264

2021-06-11 | Browse: 8 | Download: 0

Oh DH, Park DH, Ryu SH, Ha JH, Jeon HJ. Psychological predictors of bipolarity in panic disorder. World J Psychiatr 2021; 11(6): 242-252

2021-06-11 | Browse: 9 | Download: 1

Ma ZR, Ma WH, Idris S, Pan QW, Baloch Z. COVID-19 impact on high school student’s education and mental health: A cohort survey in China. World J Psychiatr 2021; 11(6): 232-241

2021-06-11 | Browse: 7 | Download: 0

Mazza M, Marano G, del Castillo AG, Chieffo D, Monti L, Janiri D, Moccia L, Sani G. Intimate partner violence: A loop of abuse, depression and victimization. World J Psychiatr 2021; 11(6): 215-221

2021-06-11 | Browse: 9 | Download: 0

Artin H, Zisook S, Ramanathan D. How do serotonergic psychedelics treat depression: The potential role of neuroplasticity. World J Psychiatr 2021; 11(6): 201-214

2021-06-11 | Browse: 8 | Download: 0

Berner-Hansen V, Olsen AA, Brandstrup B. Endoscopic treatment of primary aorto-enteric fistulas: A case report and review of literature. World J Gastrointest Endosc 2021; 13(6): 189-197

2021-06-10 | Browse: 7 | Download: 0

Maniere T, Aboudan C, Deslauriers N, Pichette M, Bergeron E. First splenic rupture following an endoscopic esophageal myotomy: A case report. World J Gastrointest Endosc 2021; 13(6): 184-188

2021-06-10 | Browse: 9 | Download: 1

Cawich SO, Sinanan A, Deshpande RR, Gardner MT, Pearce NW, Naraynsingh V. Anatomic variations of the intra-hepatic biliary tree in the Caribbean: A systematic review. World J Gastrointest Endosc 2021; 13(6): 170-193

2021-06-10 | Browse: 7 | Download: 0

Weissman S, Ahmed M, Baniqued MR, Ehrlich D, Tabibian JH. Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. World J Gastrointest Endosc 2021; 13(6): 161-169

2021-06-10 | Browse: 10 | Download: 1

2021-06-08 | Browse: 30 | Download: 25

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Published Articles Processes

Berry CA. Nuances of oblique lumbar interbody fusion at L5-S1: Three case reports. World J Orthop 2021; 12(6): 445-455

2021-06-11 | Browse: 5 | Download: 0

Vescio A, Testa G, Amico M, Lizzio C, Sapienza M, Pavone P, Pavone V. Arthroereisis in juvenile flexible flatfoot: Which device should we implant? A last five years literature systematic review. World J Orthop 2021; 12(6): 433-444

2021-06-11 | Browse: 5 | Download: 0

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2021-06-11 | Browse: 8 | Download: 0

Chillemi C, Paglialunga C, De Giorgi G, Proietti R, Carli S, Damo M. Outcome and revision rate of uncemented humeral head resurfacing: Mid-term follow-up study. World J Orthop 2021; 12(6): 403-411

2021-06-11 | Browse: 4 | Download: 0

Rosas S, Schallmo M, Gowd AK, Akelman MR, Luo TD, Emory CL, Plate JF. Dermatomyositis and polymyositis in total hip arthroplasty. World J Orthop 2021; 12(6): 395-402

2021-06-11 | Browse: 4 | Download: 0

Castagnini F, Caternicchia F, Biondi F, Masetti C, Faldini C, Traina F. Off-the-shelf 3D printed titanium cups in primary total hip arthroplasty. World J Orthop 2021; 12(6): 376-385

2021-06-11 | Browse: 4 | Download: 0

Gabel CP, Guy B, Mokhtarinia HR, Melloh M. Slacklining: A narrative review on the origins, neuromechanical models and therapeutic use. World J Orthop 2021; 12(6): 360-375

2021-06-11 | Browse: 8 | Download: 0

2021-06-11 | Browse: 4 | Download: 0

Zhang ZY, Zhang XA, Chen Q, Wang JY, Li Y, Wei ZY, Wang ZC. Listeria monocytogenes bacteremia in a centenarian and pathogen traceability: A case report. World J Clin Cases 2021; 9(18): 4873-4880

2021-06-11 | Browse: 4 | Download: 0

Wang GH, Shen HP, Chu ZM, Shen J. Adult rhabdomyosarcoma originating in the temporal muscle, invading the skull and meninges: A case report. World J Clin Cases 2021; 9(18): 4866-4872

2021-06-11 | Browse: 5 | Download: 0

2021-06-11 | Browse: 4 | Download: 0

Ji W, Nie M, Mao JF, Zhang HB, Wang X, Wu XY. Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report. World J Clin Cases 2021; 9(18): 4852-4858

2021-06-11 | Browse: 5 | Download: 0

Zheng X, Sun QJ, Zhou B, Jin M, Yan S. Microscopic transduodenal excision of an ampullary adenoma: A case report and review of literature. World J Clin Cases 2021; 9(17): 4844-4851

2021-06-11 | Browse: 3 | Download: 0

Shi XY, Cai MT, Shen H, Zhang JX. Central pontine myelinolysis mimicking glioma in diabetes: A case report. World J Clin Cases 2021; 9(18): 4837-4843

2021-06-11 | Browse: 5 | Download: 0

Leão I, Marinho J, Costa T. Long-term response to avelumab and management of oligoprogression in Merkel cell carcinoma: A case report. World J Clin Cases 2021; 9(18): 4829-4836

2021-06-11 | Browse: 5 | Download: 0

Yu QW, Ye TF, Qian WJ. Rare coexistence of multiple manifestations secondary to thalamic hemorrhage: A case report. World J Clin Cases 2021; 9(18): 4817-4822

2021-06-11 | Browse: 3 | Download: 0

Wei ZJ, Zhu X, Yu HT, Liang ZJ, Gou X, Chen Y. Severe hematuria due to vesical varices in a patient with portal hypertension: A case report. World J Clin Cases 2021; 9(18): 4810-4816

2021-06-11 | Browse: 5 | Download: 0

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Reader Comments

"Very good article, analyzing the interference of Alzheimer Disease and Type Two diabetes, condition often appearing in the ..." [Read more]

"Very good article, analyzing the interference of Alzheimer Disease and Type Two diabetes, condition often appearing in the elderly. The authors analyze the molecular picture of the two conditions, as well as the points of interference of the two incurable condition. " [Collapse]

Rojas M, Chávez-Castillo M, Bautista J, Ortega Á, Nava M, Salazar J, Díaz-Camargo E, Medina O, Rojas-Quintero J, Bermúdez V. Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links. World J Diabetes 2021; 12(6): 745-766 [DOI: 10.4239/wjd.v12.i6.745]

"Han et al have carried out a network meta-analysis of randomized controlled trials studies to review and compare response rates, ..." [Read more]

"Han et al have carried out a network meta-analysis of randomized controlled trials studies to review and compare response rates, survival outcomes, and safety of first-line systemic therapies for advanced hepatocellular carcinoma [1]. We praise and applaud their imperative research, but several important issues should be noted. First, in the “eligibility criteria” subheading of the paper, the author stated the inclusion and exclusion criteria but these are not based on PICO and PRISMA statement (PRISMA 2009 checklist, item 6) [2-4]. In this section, readers cannot properly understand what intervention (s) have been examined and what the comparison (s) are and what the outcome (s) have been examined. Second, in the “Information sources, search strategy, and study selection” subheading of the paper, the author stated that “Studies were identified by searching the following electronic databases: PubMed, Science Direct, and the Cochrane Database, and etc”. It is very clear that “Science Direct” is not a database, and is a website which provides access to a large bibliographic database of scientific and medical publications of the Dutch publisher Elsevier. The authors of the article did not mention any reason why they did not search important databases such as Scopus, Web of Science and Embase. This issue is also not mentioned in the study limitations section. However, authors in Figure 1 stated that the Embase database is searched, which is not in line with the text. Also, based on the PRISMA statement 2009, items 7 and 8, authors should indicate the databases with dates of coverage, and any limits used in search. There is a possibility of publication bias in this case. In addition, the authors did not give us any information about the “study selection” (PRISMA statement 2009, item 9). The quality assessment stage is also interestingly stated in this section. According to PRISMA, this is a major step and should be taken in a separate section (PRISMA statement 2009, items 12 and 15). Third, in the “Studies included in the analysis” subheading of the paper, the author stated that of 86 articles, 27 met the inclusion criteria. Based on the PRISMA statement, item 17, the reason for exclusion at each stage must be stated. These reasons can be in the text or in the flow chart. In this study, the reasons for exclusions are not mentioned in any section. Forth, in the “Quality assessment” subheading of the paper, the author stated that “study design characteristics are summarized in Supplementary Figure 1”, however, only “Risk of bias across studies” is given in the supplement and the results related to “Risk of bias in individual studies” are not mentioned. In addition, there is no information about the emission bias in this section. (PRISMA statement, items 19 and 22). References 1 Han Y, Zhi W-H, Xu F, Zhang C-B, Huang X-Q, Luo J-F. Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials. World journal of gastroenterology 2021; 27(19): 2415 2 Arab-Zozani M, Hassanipour S. Following PRISMA in a Systematic Review: Obligation or Authority? Int J Prev Med 2020; 11: 70-70 [PMID: 32742614 DOI: 10.4103/ijpvm.IJPVM_400_19] 3 Arab-Zozani M, Ghoddoosi-Nejad D, Dehghani M. Tips on Reporting a Systematic Review. Bulletin of emergency and trauma 2018; 6(1): 71-72 [PMID: 29379813 PMCID: PMC5787367 DOI: 10.29252/beat-060111] 4 Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of internal medicine 2009; 151(4): 264-269, w264 [PMID: 19622511 DOI: 10.7326/0003-4819-151-4-200908180-00135] " [Collapse]

Han Y, Zhi WH, Xu F, Zhang CB, Huang XQ, Luo JF. Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials. World J Gastroenterol 2021; 27(19): 2415-2433 [PMID: 34040331 DOI: 10.3748/wjg.v27.i19.2415]

"Very interesting study that open new ways to the use of bone marrow cells"

Matta A, Nader V, Galinier M, Roncalli J. Transplantation of CD34+ cells for myocardial ischemia. World J Transplant 2021; 11(5): 138-146 [PMID: 34046316 DOI: 10.5500/wjt.v11.i5.138]

"It is a good explanation about how ACEi works in the liver, but this article explain about the missing ling is about the explanation ..." [Read more]

"It is a good explanation about how ACEi works in the liver, but this article explain about the missing ling is about the explanation the metformin as a common medication. The interesting things is post mortem examination how the microvascular steatosis and mild inflammation infiltrates in liver does meaningful for next research. The drawback for this article are not stated that about the gender, ages, the cause of liver disease and the possibility using the drug. What kind of drug use, the interaction. The article discuss about the relationship between how the ACEi expression not in the human. Overall it is a good article to read. " [Collapse]

Leowattana W. Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients. World J Virol 2021; 10(3): 86-96 [PMID: 34079691 DOI: 10.5501/wjv.v10.i3.86]

"Interesting topic, generally well written, enough accurate the method and statistical section. Highly valuable "

Yang XJ, Liu D, Ren HY, Zhang XY, Zhang J, Yang XJ. Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients. World J Gastroenterol 2021; 27(19): 2376-2393 [PMID: 34040329 DOI: 10.3748/wjg.v27.i19.2376]

"Poddighe and Abdukhakimova [1] have carried out the prevalence of celiac disease (CD) in Asian countries. In this study, researchers ..." [Read more]

"Poddighe and Abdukhakimova [1] have carried out the prevalence of celiac disease (CD) in Asian countries. In this study, researchers examined the prevalence of the disease in several selected countries such as China, Japan, Southeast Asia, Russia, and Central Asia. The conclusion of the researchers of this study was the underestimation of CD in Asian countries, especially in Russia and Central Asia. Outside the Indian subcontinent and the Middle East, the epidemiological burden of celiac disease is underestimated in Asia, especially in Russia and Central Asia, where wheat is a staple food and its genetic potential is comparable to that of European countries. The reason for this finding is insufficient knowledge of physicians, limited access to diagnostic resources, inadequate interpretation of existing serological tests, and lack of diagnostic standards [2]. The results of this study are valuable, but mentioning a few points can improve the quality of this report. First, there is no mention of a comprehensive study by Sing et al [3]. On the global epidemiology of CD. In this study, the global prevalence of the disease was estimated to be 1.4% based on anti-tissue transglutaminase and/or anti-endomysial antibodies and 0.7% based on biopsy-confirmed celiac disease. The prevalence of celiac disease was 0.4% in South America, 0.5% in Africa and North America, 0.6% in Asia, and 0.8% in Europe and Oceania. The prevalence was higher in women than in men (0.6 vs. 0.4; P <0.001). The prevalence of celiac disease in children was significantly higher than in adults (0.9 vs. 0.5; P <0.001). The second point is that to estimate the burden of the disease in different countries, all the researches should be included, for example, in China and Japan, are the articles that are not written in English mentioned? Given that the authors of this study are from Kazakhstan and that they correctly referred to studies published in Russia and Central Asia in languages other than English, the authors' conclusion of the CD in the Central Asian region can be trusted. References 1 D P, D A. Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers. World journal of gastroenterology 2021; 27(19): 2251-2256 2 Agarwal A, Chauhan A, Ahuja V, Makharia GK. Opportunities and challenges in the management of celiac disease in Asia. JGH Open 2020; 4(5): 795-799 [PMID: 33102747 DOI: 10.1002/jgh3.12381] 3 Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, Kelly CP, Ahuja V, Makharia GK. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018; 16(6): 823-836.e822 [PMID: 29551598 DOI: 10.1016/j.cgh.2017.06.037] " [Collapse]

Poddighe D, Abdukhakimova D. Celiac Disease in Asia beyond the Middle East and Indian subcontinent: Epidemiological burden and diagnostic barriers. World J Gastroenterol 2021; 27(19): 2251-2256 [PMID: 34040319 DOI: 10.3748/wjg.v27.i19.2251]

"The authors used populational data on Vitamin D levels and severity/moratality data on COVID-19 in Europe. The data is interesting, ..." [Read more]

"The authors used populational data on Vitamin D levels and severity/moratality data on COVID-19 in Europe. The data is interesting, but the COVID-19 outcome may be affected by many aspects. The topic remains controversial, due to the conflicting results with a few reports regarding the relation between Vitamin D deficiency and COVID-19." [Collapse]

Papadimitriou DT, Vassaras AK, Holick MF. Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths: An ecological integrative approach. World J Virol 2021; 10(3): 111-129 [PMID: 34079693 DOI: 10.5501/wjv.v10.i3.111]

"very interesting topic ... I would be curious to evaluate the same results in terms of bridge and downstaging to extend the milan ..." [Read more]

"very interesting topic ... I would be curious to evaluate the same results in terms of bridge and downstaging to extend the milan criteria. thank you" [Collapse]

Conticchio M, Inchingolo R, Delvecchio A, Laera L, Ratti F, Gelli M, Anelli F, Laurent A, Vitali G, Magistri P, Assirati G, Felli E, Wakabayashi T, Pessaux P, Piardi T, di Benedetto F, de'Angelis N, Briceño J, Rampoldi A, Adam R, Cherqui D, Aldrighetti LA, Memeo R. Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria. World J Gastroenterol 2021; 27(18): 2205-2218 [PMID: 34025074 DOI: 10.3748/wjg.v27.i18.2205]

"I am not a virologist nor a doctor in medicine. I am a nuclear physicist using statistics. Statistics is carefully treated although ..." [Read more]

"I am not a virologist nor a doctor in medicine. I am a nuclear physicist using statistics. Statistics is carefully treated although (probably) more statistical parameters should be quoted to support conclusions. Consequently, i am not able to answer honestly about reported references(11): my answer 11 is only approximate. " [Collapse]

"Invited Comment/ Editorial “Hepatitis E – It is not always about the liver” Sandy, Natascha Silva1, Vieira Neto, Ronan José ..." [Read more]

"Invited Comment/ Editorial “Hepatitis E – It is not always about the liver” Sandy, Natascha Silva1, Vieira Neto, Ronan José 2 1. Division of Gastroenterology, Hepatology and Nutrition and the Transplant and Regenerative Medicine Center, SickKids Hospital. Department of Pediatrics, University of Toronto, Toronto, ON, Canada. 2. Division of Neurology and Stroke Program, Toronto Western Hospital. University Health Network, Toronto, On, Canada. Address correspondence to Natascha Silva Sandy, MD, Division of Gastroenterology, Hepatology and Nutrition, SickKids Hospital, 555 University Ave, M5G 1X8, Toronto, ON, Canada (e-mail: natascha.silvasandy@sickkids.ca) See “Neurological manifestations of hepatitis E virus infection: An overview”. by Jha et al - World J Gastroenterol 2021; 27(18): 2090-2104 [DOI: 10.3748/wjg.v27.i18.2090] Initially called "non-A, non-B hepatitis", the Hepatitis E Virus (HEV) was first described in the 1980s, in a hepatitis epidemic in India, transmitted via the fecal-oral route.(1) Since then, we have consolidated good knowledge about the biological behavior of this virus, and a few well-established facts about HEV have been described. Molecular characterization of HEV revealed several genotypes, and four (HEV genotypes 1 to 4) were recognized as responsible for or most infections in humans(2). Epidemiological and clinical data have documented that the majority of individuals who acquire HEV will be either asymptomatic or will present with a "flu-like" illness, but the most well-known facet of this infection is the presentation with “icteric hepatitis”, reported in 5%–40% of affected individuals.(2, 3) Another widespread observation about HEV infection is that there is a mortality rate among pregnant females, as well as in individuals with underlying chronic liver disease.(2) Nevertheless recently, what we know about this virus has been challenged by recent studies reporting emerging new data on the epidemiology as well as on the epidemiology and clinical presentation of HEV. Notably, an important concept that was changed was the initial belief that this virus could not cause chronic infection, as chronic hepatitis was consistently reported in immunosuppressed patients, including patients who have received a solid-organ transplant, patients with hematological patients and HIV-positive patients.(4) The majority of studies on Hepatitis E Virus (HEV) Infection have been conducted in Asia, as HEV is reported to be highly endemic in several parts of Asia the Middle East, Africa, and Central America.(5) But recently, many studies have recognized the impact of HEV infection in other countries.(6) Over the past decades, in regions like in different countries in Europe – which were not the traditionally recognized areas of HEV outbreaks, the number of cases of HEV infection is steadily increasing.(2, 6-8) On the clinical side, extrahepatic Manifestations of HEV, including a range of neurological, renal, pancreatic, and haematological disorders are also becoming increasingly recognized, particularly neurological injury.(9, 10) In this issue of the journal, Jha et al. (11) summarize evidence of neurological manifestations of HEV infection in a mini-review that provides a comprehensive overview of the involvement of both the peripheral nervous system and central nervous system secondary to the infection. As reported by the authors, manifestations may include Neuralgic amyotrophy, Guillain-Barré syndrome, Meningoencephalitis, Cerebral ischemia, Seizures, Transverse myelitis, Mononeuritis multiplex, Peripheral neuropathy, Cranial nerve neuropathy, Myositis, Myasthenia gravis and Meningoradiculitis. Each of these manifestations being relative rare, with a total number of cases reported varying from 1 to 64. The increasing interest in this facet of the disease may reveal that the extent of neurological finings secondary to HEV may go beyond these descriptions, as many of these neurological manifestations are often described as idiopathic but testing for HEV infection is not routine. Unfortunately, the evidence to fully understand the neurologic impact of HEV is still scarce. Until we can fully understand the importance of HEV in neurologic syndromes, prospective multicenter studies – like the one by Dalton et al., even if they are to find a small number of cases (11 out of 464 patients presenting with acute non-traumatic neurological injury in that study)(10) and reviews grouping theses cases together, like the one present in this current edition of the Word Journal of Gastroenterology by Jha et al. (11) are of great importance. REFERENCES 1. Balayan MS, Andjaparidze AG, Savinskaya SS, Ketiladze ES, Braginsky DM, Savinov AP, et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology. 1983;20(1):23-31. 2. Kamar N, Dalton HR, Abravanel F, Izopet J. Hepatitis E virus infection. Clin Microbiol Rev. 2014;27(1):116-38. 3. Kamar N, Izopet J, Pavio N, Aggarwal R, Labrique A, Wedemeyer H, et al. Hepatitis E virus infection. Nat Rev Dis Primers. 2017;3:17086. 4. Kamar N, Bendall R, Legrand-Abravanel F, Xia N-S, Ijaz S, Izopet J, et al. Hepatitis E. The Lancet. 2012;379(9835):2477-88. 5. Aggarwal R. Hepatitis E: Historical, contemporary and future perspectives. J Gastroenterol Hepatol. 2011;26 Suppl 1:72-82. 6. Frias M, López-López P, Rivero A, Rivero-Juarez A. Role of Hepatitis E Virus Infection in Acute-on-Chronic Liver Failure. Biomed Res Int. 2018;2018:9098535. 7. Ijaz S, Arnold E, Banks M, Bendall RP, Cramp ME, Cunningham R, et al. Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics. J Infect Dis. 2005;192(7):1166-72. 8. Nijskens CM, Pas SD, Cornelissen J, Caliskan K, Hoek RA, Hesselink DA, et al. Hepatitis E virus genotype 3 infection in a tertiary referral center in the Netherlands: Clinical relevance and impact on patient morbidity. J Clin Virol. 2016;74:82-7. 9. Dalton HR, Kamar N, van Eijk JJ, McLean BN, Cintas P, Bendall RP, et al. Hepatitis E virus and neurological injury. Nat Rev Neurol. 2016;12(2):77-85. 10. Dalton HR, van Eijk JJJ, Cintas P, Madden RG, Jones C, Webb GW, et al. Hepatitis E virus infection and acute non-traumatic neurological injury: A prospective multicentre study. J Hepatol. 2017;67(5):925-32. 11. Jha AK, Kumar G, Dayal VM, Ranjan A, Suchismita A. Neurological manifestations of hepatitis E virus infection: An overview. World J Gastroenterol 2021; 27(18): 2090-2104 [DOI: 10.3748/wjg.v27.i18.2090] Author contributions: Sandy NS and Vieira Neto reviewed the original manuscript, wrote and revised the letter. " [Collapse]

Jha AK, Kumar G, Dayal VM, Ranjan A, Suchismita A. Neurological manifestations of hepatitis E virus infection: An overview. World J Gastroenterol 2021; 27(18): 2090-2104 [PMID: 34025066 DOI: 10.3748/wjg.v27.i18.2090]

"This review manuscript deals with wearable devices related to heath care and presents up-to-date wearable technology to monitor many ..." [Read more]

"This review manuscript deals with wearable devices related to heath care and presents up-to-date wearable technology to monitor many parameters associated with physical activity and health care. The topic of this manuscript is very interesting and straightforward, and contributes to more effective treatment using wearable devices. If the authors added in detail comparisons the results of new wearable devices to those of normal devices or modalities which are commonly used in hospitals, the manuscript would be more intriguing and convincing." [Collapse]

Chong KP, Woo BK. Emerging wearable technology applications in gastroenterology: A review of the literature. World J Gastroenterol 2021; 27(12): 1149-1160 [PMID: 33828391 DOI: 10.3748/wjg.v27.i12.1149]

"Under the special background of pandemic, the diagnosis and treatment of abdominal diseases are fraught with difficulties and ..." [Read more]

"Under the special background of pandemic, the diagnosis and treatment of abdominal diseases are fraught with difficulties and challenges. Novel coronavirus infection may overlap abdominal symptoms with other abdominal inflammation, which is a wake-up call for clinicians. In particular, novel coronavirus may constitute the direct cause of cholecystitis and hepatitis, thus giving clinicians more thought. It is hoped that the diagnosis and treatment of hepatic and gall diseases by clinicians can be more accurate and the etiology can be explored, instead of just making diagnosis and treatment in this special period. The purpose of this article is to analyze the molecular level risk of gastrointestinal organ novel coronavirus inflammation. We read with great interest of this article in your journal about the high expression of ACE-2 in the liver and gall of COVID-infected patients. In other words, it's time to think about the molecular mechanisms by which viruses infect organs. Combined with the inter-action between ACE2 and novel coronavirus, we further considered the potential pathological and molecular characteristics of novel coronavirus, and antiviral measures of digestive organs. This is particularly important as the pandemic intensifies." [Collapse]

"This minireview is on the gastrointestinal effects of radiation. As a whole, the details were written in an easy-to-understand ..." [Read more]

"This minireview is on the gastrointestinal effects of radiation. As a whole, the details were written in an easy-to-understand manner. My only comment is that I wondered why small bowel was next to esophagus instead of stomach. Radiation-induced gastritis occurs in about 30–50% of patients undergoing radiation therapy whenever the stomach is included in radiation fields as the main target or an organ at risk. (Ainaz Sourati et al. Radiation Gastritis in Acute Side Effects of Radiation Therapy pp 133-136, 2017) I wish there were a section on radiation gastritis. " [Collapse]

McCaughan H, Boyle S, McGoran JJ. Update on the management of the gastrointestinal effects of radiation. World J Gastrointest Oncol 2021; 13(5): 400-408 [PMID: 34040701 DOI: 10.4251/wjgo.v13.i5.400]

"Comment on “Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis” Xiao-Long Tang, Yan-Dong ..." [Read more]

"Comment on “Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis” Xiao-Long Tang, Yan-Dong Miao, Deng-Hai Mi Xiao-Long Tang, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China The Second Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong City, Sichuan Province, China Yan-Dong Miao, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China Deng-Hai Mi, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, PR China Gansu Academy of Traditional Chinese Medicine, Lanzhou City, Gansu Province, China Author contributions: Xiao-Long Tang and Yan-Dong Miao designed research; Xiao-Long Tang and Yan-Dong Miao performed research; Xiao-Long Tang and Yan-Dong Miao analyzed data; Xiao-Long Tang wrote the comment; and Deng-Hai Mi revised the comment. Supported by: the Special Plan for Condition Construction of Gansu Provincial Scientific Research Institutes (Grants No. 20JR10RA432) Corresponding author: Deng-Hai Mi, MD, Gansu Academy of Traditional Chinese Medicine, Lanzhou City, Gansu Province, China. mi.dh@outlook.com Abstract The present comment to the editor is related to Omar Elshaarawy et al. Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis. World J Gastroenterol 2021;13(5):424-439. Preoperative evaluation of liver reserve function in hepatocellular carcinoma (HCC) patients with cirrhosis is critical, and there is no global consensus on how to evaluate it. Through retrospective analysis, Omar Elshaarawy et al. evaluated the influence of various traditional clinical indicators on liver failure and prognosis after hepatectomy in HCC patients with cirrhosis. We suggest that we should make an effort to look for new evaluation indicators such as indocyanine green retention rate at 15 min (ICG-R15). Keywords: ICG-R15, hepatectomy, Cirrhosis, Hepatocellular carcinoma Core tip: Improper hepatectomy can lead to liver failure and even death for HCC patients with cirrhosis. The major highlight of this comment is to stress the urgency of searching and validating new predictors before hepatectomy in HCC patients with cirrhosis. TO THE EDITOR In “Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis”, Omar Elshaarawy et al. assessed many traditional predictors for liver failure and prognosis in cirrhosis patients undergoing radical resection of HCC via univariate and multivariate analyses[1]. They found that the preoperative MELD score, tumor diameter, length of stay after radical resection of liver cancer, and hospital stay length are significant independent predictors of liver decompensation. Preoperative MELD score, different levels of PHLF, and postoperative HCC recurrence resection are significant independent predictors of prognosis. This research is valuable information and is helpful for doctors to improve the preoperative evaluation of HCC patients with cirrhosis. Although we appreciate this work very much, we consider that the article would have been far more interesting if the author had adopted the indocyanine green retention rate at 15 min (ICG-R15). For more details about this opinion, we are looking forward to evaluation and discussion with the authors. With the remarkable progress of surgical techniques, the methods of hepatectomy are becoming more and more radical. Improper surgery can lead to liver failure and even death. It is valuable for the surgeon to focus on verifying significant predictors of postoperative liver decompensation and prognosis. As we all know, The ICG-R15 is superior to many biochemical measures as a single assessment and has been widely used for the preoperative evaluation of hepatic functional reserve. However, the ICG-R15, a sensitive predictor of liver function reserve, was not mentioned in this study. ICG is selectively ingested by liver cells after injection, secreted by liver cells into bile, and rapidly excreted by the biliary tract[2]. ICG does not have any chemical reaction in the body and is only excreted from the liver, so that it can be a good assessment of liver function reserve. ICG-R15 can respond to the current liver function injury when there are no abnormalities in many conventional biochemical indicators. Thus it provides the necessary means for clinical prevention of surgical trauma, liver loss of blood, and other blows caused by acute liver failure. Recently, Kokudo, Takashi et al. noted that ICG R15 might enhance physicians' ability to stratify patients at risk for postoperative liver failure[3]. Furthermore, Wang, Yan-Yan et al. based on a comparative study of 185 patients, demonstrated that ICG-R15 is more reliable than the MELD score and Child-Pugh score in predicting hepatic functional reserve before hepatectomy[4]. Accurate evaluation of liver function reserve is very important for the correct treatment of HCC patients with cirrhosis. Correct preoperative evaluation is vital to patient recovery. Although no global consensus on the evaluation tool for the liver functional reserve is currently available, we feel that we should actively explore more novel and valuable predictors to adapt to the development of surgical techniques. ACKNOWLEDGEMENTS This work was supported by the Special Plan for Condition Construction of Gansu Provincial Scientific Research Institutes (Grants No. 20JR10RA432). REFERENCES 1 Elshaarawy O, Aman A, Zakaria HM, Zakareya T, Gomaa A, Elshimi E, Abdelsameea E. Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis. WJGO 2021; 13: 424–439. [DOI: 10.4251/wjgo.v13.i5.424] 2 Inagaki Y, Kokudo T, Kamiya M, Uno S-N, Sato M, Kaneko J, Kokudo N, Urano Y, Hasegawa K. A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green. Sci Rep 2019; 9: 3044. [PMID: 30816163 DOI: 10.1038/s41598-019-39269-0] 3 Kokudo T, Hasegawa K, Shirata C, Tanimoto M, Ishizawa T, Kaneko J, Akamatsu N, Arita J, Demartines N, Uldry E, Kokudo N, Halkic N. Assessment of Preoperative Liver Function for Surgical Decision Making in Patients with Hepatocellular Carcinoma. Liver Cancer 2019; 8: 447–456. [PMID: 31799202 DOI: 10.1159/000501368] 4 Wang Y-Y, Zhao X-H, Ma L, Ye J-Z, Wu F-X, Tang J, You X-M, Xiang B-D, Li L-Q. Comparison of the ability of Child-Pugh score, MELD score, and ICG-R15 to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma. J Surg Oncol 2018; 118: 440–445. [PMID: 30259515 DOI: 10.1002/jso.25184] " [Collapse]

Elshaarawy O, Aman A, Zakaria HM, Zakareya T, Gomaa A, Elshimi E, Abdelsameea E. Outcomes of curative liver resection for hepatocellular carcinoma in patients with cirrhosis. World J Gastrointest Oncol 2021; 13(5): 424-439 [PMID: 34040703 DOI: 10.4251/wjgo.v13.i5.424]

"Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the destruction of insulin producing cells in islets by ..." [Read more]

"Type 1 diabetes mellitus (T1D) is an autoimmune disease characterized by the destruction of insulin producing cells in islets by autoreactive T cells β Cells, leading to high blood sugar levels and serious long-term complications. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) specialized in the initiation of both immunogenic and tolerogenic response. DC antigen presentation is in the early stage of immune response，so it has a great effect on the control of disease development. The use of tolDC as alternative immunotherapy arises as a promising approach for T1D therapy. In this paper, the author makes a full and detailed review of tolDC induction and application in preclinical and clinical." [Collapse]

Ríos-Ríos WJ, Sosa-Luis SA, Torres-Aguilar H. Current advances in using tolerogenic dendritic cells as a therapeutic alternative in the treatment of type 1 diabetes. World J Diabetes 2021; 12(5): 603-615 [PMID: 33995848 DOI: 10.4239/wjd.v12.i5.603]

"Fecal incontinence (FI) causes severe psychological and financial burden, and extremely reduced the patients’ quality of life. The ..." [Read more]

"Fecal incontinence (FI) causes severe psychological and financial burden, and extremely reduced the patients’ quality of life. The true incidence of FI may be underestimated. The present review gave a brief introduction of the etiology of FI in adults, and described several commonly used methods for the evaluation of FI. However, based on our clinical experience, we believe that some related information were not sufficiently discussed in this article. 1. Causes and risk factors FI is a multifactorial disease. In this section, the authors listed the main causes and risk factors of FI. We noticed that fecal impaction and impaired rectal compliance were not mentioned, yet they are also common causes of FI. It would be better to categorize the causes of FI according to the main mechanisms instead of simply make a list of all the related diseases. The header of Table 1 was missing, and the first row of content was incorrectly bolded. Besides, there were some language mistakes or typo's in Table 1. ‘Congenital/ Acquired neurological’ should be ‘Congenital/ Acquired neurological disease’, and ‘Ana cancer’ was probably a misspelling of “Anal cancer”. 2. History taking & physical examination In this part, the authors summarized the key informations that should be collected during history taking. In our perspective, there is still one thing to add. Since the stool form is an influencing factor of the continence mechanism that cannot be neglected, it would be better to assess the stool form with varified universal scales, e.g. Bristol stool form scale. What’s more, the severity of FI should also be quantified with patient reported scales. The content in this section was too general to be used as a ‘practical tool box’. A checklist which covers the main points of history taking will be more helpful in clinical practise. Japanese Practice Guidelines for Fecal Incontinence has given a great example in this aspect. 3. Diagnostic tools The authors gave a very comprehensive introduction of commonly used clinical diagnostic and assessment tools of FI, including HRAM, EAUS & MRI, as well as electromyography. As far as we know, defecography is an important method in assessing the morphological movement of rectum and the pelvic floor muscles. Unfortunately, in this section, the introduction of MRI defecography was too brief, and failed to reveal its role in disease diagnosis and surgical intervention sufficiently. Nevertheless, barium defecography was not mentioned. The last figure of this review showed a stepwise approach of faecal incontinence investigation, which may contribute to better clinical decision making. In conclusion, this review provided an comprehensive overview of FI, but the main weakness of it was the missing of some significant information and the lack of novelty. Space limitation may be responsible for this disadvantage. We sincerely looking forward to the authors’ future work. Xiyue Hu, M.D., Zheng Liu, M.D. Dept. of Colorectal Surgery National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Science 17 Panjiayuan Nanli, Chaoyang District, Beijing, China, 100021" [Collapse]

Sbeit W, Khoury T, Mari A. Diagnostic approach to faecal incontinence: What test and when to perform? World J Gastroenterol 2021; 27(15): 1553-1562 [PMID: 33958842 DOI: 10.3748/wjg.v27.i15.1553]

"This is a sound mini-review of an important topic in general. However, it would have been a more robust reveiw if it had discerned ..." [Read more]

"This is a sound mini-review of an important topic in general. However, it would have been a more robust reveiw if it had discerned crucial differences between binary vs. multinomial classfications of tumors in terms of methods, results and implications. " [Collapse]

Shao Y, Zhang YX, Chen HH, Lu SS, Zhang SC, Zhang JX. Advances in the application of artificial intelligence in solid tumor imaging. Artif Intell Cancer 2021; 2(2): 12-24 [DOI: 10.35713/aic.v2.i2.12]

"The review summarizes recent data on gastrointestinal manifestations in patients with COVID-19 infection in a ways, similar to ..." [Read more]

"The review summarizes recent data on gastrointestinal manifestations in patients with COVID-19 infection in a ways, similar to previous several reviews devoted to the same topic. The scope of review is mostly concentrated on functional disorders, while severe gastrointestinal complications were almost uncovered. This is related to intestinal microbiota as well - issues related to Cl.difficile infection, pseudomembranous colitis were not discussed. Functional disorders lack description of psychological changes in COVID-19 patients." [Collapse]

Jin B, Singh R, Ha SE, Zogg H, Park PJ, Ro S. Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19. World J Gastroenterol 2021; 27(19): 2341-2352 [PMID: 34040326 DOI: 10.3748/wjg.v27.i19.2341]

"The topic is very actual - both from diagnostic and management points of view. Review summarizes different studies with different ..." [Read more]

"The topic is very actual - both from diagnostic and management points of view. Review summarizes different studies with different severity and stage of pancreatic cancer. However article is a bit overloaded with statistical information while lacking practical outcomes." [Collapse]

Frere C. Burden of venous thromboembolism in patients with pancreatic cancer. World J Gastroenterol 2021; 27(19): 2325-2340 [PMID: 34040325 DOI: 10.3748/wjg.v27.i19.2325]

"The article represents good-quality review representing both pathogenesis and diagnostic approach in IgG4-related disease that ..." [Read more]

"The article represents good-quality review representing both pathogenesis and diagnostic approach in IgG4-related disease that describes the new horizons of research in the field. " [Collapse]

Hara A, Watanabe T, Minaga K, Yoshikawa T, Kamata K, Kudo M. Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease. World J Gastroenterol 2021; 27(19): 2257-2269 [PMID: 34040320 DOI: 10.3748/wjg.v27.i19.2257]

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