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208 items Read more >>
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Araujo RLC, Carvalho CGCY, Maeda CT, Milani JM, Bugano DG, de Moraes PHZ, Linhares MM. Oncologic aspects of the decision-making process for surgical approach for colorectal liver metastases progressing during chemotherapy. World J Gastrointest Surg 2022; 14(9): 877-886 [DOI: 10.4240/wjgs.v14.i9.877]
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Villasuso-Alcocer V, Flores-Tapia JP, Perez-Garfias F, Rochel-Perez A, Mendez-Dominguez N. Serratia fonticola and its role as a single pathogen causing emphysematous pyelonephritis in a non-diabetic patient: A case report. World J Clin Cases 2022; 10(29): 10600-10605 [DOI: 10.12998/wjcc.v10.i29.10600]
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Macías-Rodríguez RU, Solís-Ortega AA, Ornelas-Arroyo VJ, Ruiz-Margáin A, González-Huezo MS, Urdiales-Morán NA, Román-Calleja BM, Mayorquín-Aguilar JM, González-Regueiro JA, Campos-Murguía A, Toledo-Coronado IV, Chapa-Ibargüengoitia M, Valencia-Peña B, Martínez-Cabrera CF, Flores-García NC. Prognostic performance of an index based on lactic dehydrogenase and transaminases for patients with liver steatosis and COVID-19. World J Gastroenterol 2022; 28(37): 5444-5456 [DOI: 10.3748/wjg.v28.i37.5444]
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Meng QQ, Gao Y, Lin H, Wang TJ, Zhang YR, Feng J, Li ZS, Xin L, Wang LW. Application of an artificial intelligence system for endoscopic diagnosis of superficial esophageal squamous cell carcinoma. World J Gastroenterol 2022; 28(37): 5483-5493 [DOI: 10.3748/wjg.v28.i37.5483]
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Wu Y, Xie CB, He YH, Ke D, Huang Q, Zhao KF, Shi RS. Three-in-one incidence of hepatocellular carcinoma, cholangiocellular carcinoma, and neuroendocrine carcinoma: A case report. World J Clin Cases 2022; 10(29): 10575-10582 [DOI: 10.12998/wjcc.v10.i29.10575]
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"We are satisfied with the speed of evaluation and peocess. we will submit different manuscript to the journal in the next few months. ..."
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"We are satisfied with the speed of evaluation and peocess. we will submit different manuscript to the journal in the next few months."
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Zhang L, Sun T, Wu XY, Fei FM, Gao ZZ. Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma. World J Clin Cases 2022; 10(29): 10501-10515 [DOI: 10.12998/wjcc.v10.i29.10501]
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Huang QF, Shao Y, Yu B, Hu XP. Chondroid syringoma of the lower back simulating lipoma: A case report. World J Clin Cases 2022; 10(29): 10708-10712 [DOI: 10.12998/wjcc.v10.i29.10708]
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Xu NW, Li LJ. Myeloproliferative neoplasms complicated with β-thalassemia: Two case report. World J Clin Cases 2022; 10(29): 10655-10662 [DOI: 10.12998/wjcc.v10.i29.10655]
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Liang L, Chen XL, Chen Y, Zhang NN. Surgical treatment of bipolar segmental clavicle fracture: A case report. World J Clin Cases 2022; 10(29): 10529-10534 [DOI: 10.12998/wjcc.v10.i29.10529]
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Jiang D, Chen ZX, Ma FX, Gong YY, Pu T, Chen JM, Liu XQ, Zhao YJ, Xie K, Hou H, Wang C, Geng XP, Liu FB. Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study. World J Gastroenterol 2022; 28(37): 5469-5482 [DOI: 10.3748/wjg.v28.i37.5469]
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"Thanks very much for your kind work and consideration on publication of our paper. On behalf of my co-authors, we would like to express ..."
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"Thanks very much for your kind work and consideration on publication of our paper. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.Thank you and best regards."
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Guo HB, Tan JB, Cui YC, Xiong HF, Li CS, Liu YF, Sun Y, Pu L, Xiang P, Zhang M, Hao JJ, Yin NN, Hou XT, Liu JY. Extracorporeal membrane oxygenation in curing a young man after modified Fontan operation: A case report. World J Clin Cases 2022; 10(29): 10614-10621 [DOI: 10.12998/wjcc.v10.i29.10614]
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Song J, Song H, Kim YW. Recurrent atypical leiomyoma in bladder trigone, confused with uterine fibroids: A case report. World J Clin Cases 2022; 10(29): 10728-10734 [DOI: 10.12998/wjcc.v10.i29.10728]
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Ge QC, Wu YF, Liu ZM, Wang Z, Wang S, Liu X, Ge N, Guo JT, Sun SY. Efficacy of endoscopic ultrasound in the evaluation of small gastrointestinal stromal tumors. World J Gastroenterol 2022; 28(37): 5457-5468 [DOI: 10.3748/wjg.v28.i37.5457]
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Jelicic P, Ferenc T, Mrzljak A, Jemersic L, Janev-Holcer N, Milosevic M, Bogdanic M, Barbic L, Kolaric B, Stevanovic V, Vujica M, Jurekovic Z, Pavicic Saric J, Vilibic M, Vilibic-Cavlek T. Insights into hepatitis E virus epidemiology in Croatia. World J Gastroenterol 2022; 28(37): 5494-5505 [DOI: 10.3748/wjg.v28.i37.5494]
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Ding YN, Xue M, Tang QS, Wang LJ, Ding HY, Li H, Gao CC, Yu WP. Immunotherapy-based novel nanoparticles in the treatment of gastrointestinal cancer: Trends and challenges. World J Gastroenterol 2022; 28(37): 5403-5419 [DOI: 10.3748/wjg.v28.i37.5403]
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Swarnakar R, Yadav SL. “Helicobacter pylori treatment guideline: An Indian perspective”: Letter to the editor. World J Clin Cases 2022; 10(29): 10817-10819 [DOI: 10.12998/wjcc.v10.i29.10817]
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Nori W, Akram W. Effect of gender on the reliability of COVID-19 rapid antigen test among elderly. World J Clin Cases 2022; 10(29): 10820-10822 [DOI: 10.12998/wjcc.v10.i29.10820]
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Meng XH, Xie LS, Xie XP, Liu YC, Huang CP, Wang LJ, Zhang GH, Xu D, Cai XC, Fang X. Cardiac myxoma shedding leads to lower extremity arterial embolism: A case report. World J Clin Cases 2022; 10(29): 10606-10613 [DOI: 10.12998/wjcc.v10.i29.10606]
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Sun YX, Wang J, Zhu JH, Yuan W, Wu L. Follicular lymphoma with cardiac involvement in a 90-year-old patient: A case report. World J Clin Cases 2022; 10(28): 10208-10213 [DOI: 10.12998/wjcc.v10.i28.10208]
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Ghosh A, Lakshmanan M, Manchanda S, Bhalla AS, Kumar P, Bhutia O, Mridha AR. Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas . World J Radiol 2022; 14(9): 329-341 [DOI: 10.4329/wjr.v14.i9.329]
10352 items Read more >>
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"The article reviews the literature data on mesenchymal stem cell (MSCs) transplantation as a treatment method for inflammatory bowel ..."
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"The article reviews the literature data on mesenchymal stem cell (MSCs) transplantation as a treatment method for inflammatory bowel disease (IBD) conforming to the advantages of this method, namely immunomodulatory and nutritional functions of MSCs. Taking into account that immune factors may be very important in the pathogenesis of IBD, MSCs have become promising candidates for the treatment of autoimmune diseases influencing the phenotype and function of innate immune cells. The authors discuss the strategies for enhancing the therapeutic effect of MSCs in the treatment of inflammatory bowel disease together with combined treatment with conventional drugs, pretreatment and gene modification. Pretreatment of MSC includes bioactive substances, hypoxic preconditioning and modification of culture methods. These methods form the basis of new strategies of the clinical application of MSCs in the treatment of IBD to achieve prolonged remission and halt any ongoing . The article is supplemented with 2 figures of a very good quality and 1 informative table. The language in the article is very good and clear. The list of references includes 121 articles from 2015 to 2022 on the topic of the review. The article gives a detailed and qualified overview of the problem, which is very useful for experts in the field."
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Shi MY, Liu L, Yang FY. Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease. World J Stem Cells 2022; 14(9): 684-699 [DOI: 10.4252/wjsc.v14.i9.684]
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"Perithyroid hemorrage due to hydrodissection has not been described. Hence this is interesting. Since its rare comlication it would ..."
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"Perithyroid hemorrage due to hydrodissection has not been described. Hence this is interesting. Since its rare comlication it would be interesting if authors suggest some modification in hydrodissection technique based on their experience to prevent hemorrage"
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Zheng BW, Wu T, Yao ZC, Ma YP, Ren J. Perithyroidal hemorrhage caused by hydrodissection during radiofrequency ablation for benign thyroid nodules: Two case reports. World J Clin Cases 2022; 10(29): 10755-10762 [DOI: 10.12998/wjcc.v10.i29.10755]
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"This is very important case. The reason for remssion was immune reconstitution, we need to have proteomics of tumor as well as ..."
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"This is very important case. The reason for remssion was immune reconstitution, we need to have proteomics of tumor as well as trancritomics of the oatient to put up a decisive hypothesis"
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Yang Y, Huang XJ. Immune checkpoint inhibitor-associated arthritis in advanced pulmonary adenocarcinoma: A case report. World J Clin Cases 2022; 10(29): 10701-10707 [DOI: 10.12998/wjcc.v10.i29.10701]
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"The sample size is small so survival analysis was not done. The parameters n figur 5 could have been analyzed by applying non ..."
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"The sample size is small so survival analysis was not done. The parameters n figur 5 could have been analyzed by applying non parametric test as comparison betwen PICU and non PICU group"
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Rodriguez-Gonzalez M, Castellano-Martinez A. Age-adjusted NT-proBNP could help in the early identification and follow-up of children at risk for severe multisystem inflammatory syndrome associated with COVID-19 (MIS-C). World J Clin Cases 2022; 10(29): 10435-10450 [DOI: 10.12998/wjcc.v10.i29.10435]
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"This report showed malpractice suits and the threat thereof may pose a significant psychological burden on young otolaryngologists. ..."
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"This report showed malpractice suits and the threat thereof may pose a significant psychological burden on young otolaryngologists. It also highlights the importance of several factors. It supports preemptive educational efforts and provides evidence-based insight for trainees in a legal predicament."
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Suresh NV, Shah VN, Fritz CG, Griff JR, Shah S, Watane A, Parikh RS, Nicolli EA. Medical malpractice litigation involving otolaryngology residents and fellows: A case-based 30-year review. World J Otorhinolaryngol 2022; 9(1): 1-11 [DOI: 10.5319/wjo.v9.i1.1]
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"This is an interesting review article describing the detrimental effects of SARS-CoV-2 infection on the cardiovascular system, and ..."
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"This is an interesting review article describing the detrimental effects of SARS-CoV-2 infection on the cardiovascular system, and explaining in detail the pathophysiological mechanisms behind these deleterious effects. "
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Xanthopoulos A, Bourazana A, Giamouzis G, Skoularigki E, Dimos A, Zagouras A, Papamichalis M, Leventis I, Magouliotis DE, Triposkiadis F, Skoularigis J. COVID-19 and the heart. World J Clin Cases 2022; 10(28): 9970-9984 [DOI: 10.12998/wjcc.v10.i28.9970]
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"Small sample size retrospective study is a drawback but it does stimulate prospective research
Multi center data from high volume ..."
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"Small sample size retrospective study is a drawback but it does stimulate prospective research
Multi center data from high volume centers is required"
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Pinheiro LW, Martins FP, De Paulo GA, Contini MLC, Ferrari AP, Della Libera E. Endoscopic therapy using a self-expandable metallic stent with an anti-migration system for postorthotopic liver transplantation anastomotic biliary stricture. World J Gastrointest Endosc 2022; 14(9): 547-554 [DOI: 10.4253/wjge.v14.i9.547]
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Takagi T, Sugimoto M, Suzuki R, Konno N, Asama H, Sato Y, Irie H, Nakamura J, Takasumi M, Hashimoto M, Kato T, Kobashi R, Yanagita T, Hashimoto Y, Marubashi S, Hikichi T, Ohira H. Screening for hilar biliary invasion in ampullary cancer patients. World J Gastrointest Endosc 2022; 14(9): 536-546 [DOI: 10.4253/wjge.v14.i9.536]
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"A practical study and has wider ramifications as it will require prospective data in the future for validation
Combined with ..."
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"A practical study and has wider ramifications as it will require prospective data in the future for validation
Combined with histopathological evaluation cut offs will need prospective derivation and validation "
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Puga-Tejada M, Del Valle R, Oleas R, Egas-Izquierdo M, Arevalo-Mora M, Baquerizo-Burgos J, Ospina J, Soria-Alcivar M, Pitanga-Lukashok H, Robles-Medranda C. Endoscopic ultrasound elastography for malignant pancreatic masses and associated lymph nodes: Critical evaluation of strain ratio cutoff value. World J Gastrointest Endosc 2022; 14(9): 524-535 [DOI: 10.4253/wjge.v14.i9.524]
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Maulahela H, Annisa NG, Konstantin T, Syam AF, Soetikno R. Simulation-based mastery learning in gastrointestinal endoscopy training. World J Gastrointest Endosc 2022; 14(9): 512-523 [DOI: 10.4253/wjge.v14.i9.512]
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"Ethics are provided. The references of the determination of IFN-gamma and IL-2 were not cited. No references are shown in the section ..."
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"Ethics are provided. The references of the determination of IFN-gamma and IL-2 were not cited. No references are shown in the section of material and methods. Results are well explained. Error bars are not seen in Figure 4. The language is fair.
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Rybicka-Ramos M, Markiewicz M, Suszka-Świtek A, Wiaderkiewicz R, Mizia S, Dzierżak-Mietła M, Białas K. Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation. World J Biol Chem 2022; 13(4): 72-82 [DOI: 10.4331/wjbc.v13.i4.72]
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"This is a well-written and presented rare case report. This manuscript gives additional new knowledge to the existing literatüre. ..."
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"This is a well-written and presented rare case report. This manuscript gives additional new knowledge to the existing literatüre. I think that this manuscript is worth to publication. "
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Wang YS, Guo QY, Zheng FH, Huang ZW, Yan JL, Fan FX, Liu T, Ji SX, Zhao XF, Zheng YX. Retrorectal mucinous adenocarcinoma arising from a tailgut cyst: A case report and review of literature. World J Gastrointest Surg 2022; 14(9): 1072-1081 [DOI: 10.4240/wjgs.v14.i9.1072]
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"In this manuscript, the authors summarized current knowledge on liver-specific drug delivery platforms, especially aiming to apply ..."
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"In this manuscript, the authors summarized current knowledge on liver-specific drug delivery platforms, especially aiming to apply for treatment of alcohol-associated liver disease. The authors searched literatures and found 16 key studies matching with their focus. Based on these 16 articles, the authors discussed the potential and problems of liver-targeting treatment for alcohol-associated liver disease. However, there are pleural issues that may make this type of discussion useless. First, a major problem in patients with alcohol-associated liver disease is not the liver pathology but the attitude toward alcohol addiction. No matter how specifically the liver is targeted for treatment, the problem of patients with alcohol abuse will not be solved. Second, given the ambiguous efficacy of both delivery system and delivered medicine, it is too primitive to evaluate a targeting treatment for the liver in alcohol-associated liver disease. The authors should discuss the rationale to focus on the content expressed in their title."
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Warner JB, Guenthner SC, Hardesty JE, McClain CJ, Warner DR, Kirpich IA. Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease. World J Gastroenterol 2022; 28(36): 5280-5299 [DOI: 10.3748/wjg.v28.i36.5280]
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"With this well written minireview, the authors summarize the role of AI in the field of endoscopic screening and surveillance of upper ..."
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"With this well written minireview, the authors summarize the role of AI in the field of endoscopic screening and surveillance of upper GI disease, underlining its future applications."
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Yoo BS, Houston KV, D'Souza SM, Elmahdi A, Davis I, Vilela A, Parekh PJ, Johnson DA. Advances and horizons for artificial intelligence of endoscopic screening and surveillance of gastric and esophageal disease. Artif Intell Med Imaging 2022; 3(3): 70-86 [DOI: 10.35711/aimi.v3.i3.70]
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"1. The ethical approval form provided by the author meet the requirements.
2. The experimental method effective and can be repeated ..."
[Read more]
"1. The ethical approval form provided by the author meet the requirements.
2. The experimental method effective and can be repeated by fellow researchers.
3. The results true and authentic and the theory or hypothesis of universal significance validated.
4. The author provide figures and tables that are confusing, poorly constructed and/or not well-annotated
5. The author provide a non perfect biostatistics data.
6. The latest references which are important in this field and related to the scientific problems and research hypotheses were not addressed in the study.
7. The language in article correctly, clearly and concisely express the information.
8. Some caveats or drawbacks for the results."
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Merchant SA, Nadkarni P, Shaikh MJS. Augmentation of literature review of COVID-19 radiology. World J Radiol 2022; 14(9): 342-351 [DOI: 10.4329/wjr.v14.i9.342]
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"and/or peer-reviewers’ reference only in evaluating an article:
The ethical approval form provided by the author meet the ..."
[Read more]
"and/or peer-reviewers’ reference only in evaluating an article:
The ethical approval form provided by the author meet the requirements.
Yhe experimental method effective and can be repeated by fellow researchers.
Yhe results true and authentic and the theory or hypothesis of universal significance validated.
Yhe author provide perfect tables, line charts and/or graphs.
The author provide perfect biostatistics data.
The latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study were not cited.
The language in article correctly, clearly and concisely express the information.
No caveats or drawbacks for the results."
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Ghosh A, Lakshmanan M, Manchanda S, Bhalla AS, Kumar P, Bhutia O, Mridha AR. Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas . World J Radiol 2022; 14(9): 329-341 [DOI: 10.4329/wjr.v14.i9.329]
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"1. The ethical approval form provided by the author meet the requirements.
2. The experimental method effective and can be repeated ..."
[Read more]
"1. The ethical approval form provided by the author meet the requirements.
2. The experimental method effective and can be repeated by fellow researchers.
3. The results true and authentic and the theory or hypothesis of universal significance validated.
4. The author provide perfect tables, line charts and/or graphs.
5. The author provide perfect biostatistics data.
6. The author scientifically and reasonably cite the latest references which are important in this field and related to the scientific problems and research hypotheses addressed in the study.
7. The language in article correctly, clearly and concisely express the information.
8. No caveats or drawbacks for the results."
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Katlariwala P, Wilson MP, Pi Y, Chahal BS, Croutze R, Patel D, Patel V, Low G. Reliability of ultrasound ovarian-adnexal reporting and data system amongst less experienced readers before and after training. World J Radiol 2022; 14(9): 319-328 [DOI: 10.4329/wjr.v14.i9.319]
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Barbiero G, Maiolino G, Argiolas A, Testolin L, De Conti G. Intra-atrial course of right coronary artery: A case report. World J Cardiol 2022; 14(9): 514-521 [DOI: 10.4330/wjc.v14.i9.514]
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Goyal A, Dalia T, Bhyan P, Farhoud H, Shah Z, Vidic A. Rare case of chronic Q fever myocarditis in end stage heart failure patient: A case report. World J Cardiol 2022; 14(9): 508-513 [DOI: 10.4330/wjc.v14.i9.508]
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Pradhan A, Vishwakarma P, Bhandari M, Sethi R. Intravascular lithotripsy for coronary calcium: A case report and review of the literature. World J Cardiol 2022; 14(9): 496-507 [DOI: 10.4330/wjc.v14.i9.496]
11145 items Read more >>
Peer-Reviewers and Manuscript Statistics
- Editorial board members
- 3131
- Peer-reviewers
- 62242
- Manuscripts received today
- 25
- Manuscript reviews today
- 44
- Unhandled manuscripts today
- 115
- Active peer-reviewers today
- 985
- Reviewer acceptance today
- 58
- Reviewer refusals today
- 79
- Total accepted manuscripts
- 25986
- Total rejected manuscripts
- 30651
- Total peer-reviewers
- 1086833
- Total submissions
- 23685
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53505 items Read more >>
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Warner JB, Guenthner SC, Hardesty JE, McClain CJ, Warner DR, Kirpich IA. Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease. World J Gastroenterol 2022; 28(36): 5280-5299 [DOI: 10.3748/wjg.v28.i36.5280]
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"The diverse functions of caldesmon related to cancer growth and metastasis indicated that it could be a potential biomarker targeting ..."
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"The diverse functions of caldesmon related to cancer growth and metastasis indicated that it could be a potential biomarker targeting CRC."
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Alnuaimi AR, Nair VA, Malhab LJB, Abu-Gharbieh E, Ranade AV, Pintus G, Hamad M, Busch H, Kirfel J, Hamoudi R, Abdel-Rahman WM. Emerging role of caldesmon in cancer: A potential biomarker for colorectal cancer and other cancers. World J Gastrointest Oncol 2022; 14(9): 1637-1653 [DOI: 10.4251/wjgo.v14.i9.1637]
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Zeng ZM, Mo N, Zeng J, Ma FC, Jiang YF, Huang HS, Liao XW, Zhu GZ, Ma J, Peng T. Advances in postoperative adjuvant therapy for primary liver cancer. World J Gastrointest Oncol 2022; 14(9): 1604-1621 [DOI: 10.4251/wjgo.v14.i9.1604]
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Nong FF, Liang YQ, Xing SP, Xiao YF, Chen HH, Wen B. Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1. World J Gastroenterol 2022; 28(35): 5154-5174 [DOI: 10.3748/wjg.v28.i35.5154]
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Liu W, Chen FL, Wang K, Bao Q, Wang HW, Jin KM, Xing BC. Irinotecan- vs oxaliplatin-based regimens for neoadjuvant chemotherapy in colorectal liver metastasis patients: A retrospective study. World J Gastrointest Surg 2022; 14(9): 904-917 [DOI: 10.4240/wjgs.v14.i9.904]
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"Comment on “ Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and ..."
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"Comment on “ Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models”
Chaolin Deng1, Bin Wu1
1 Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Corresponding author: Bin Wu, MD, Chief Doctor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Road, Wangfujing, Dongcheng District, Beijing 100730, China. Email:wubin0279@hotmail.com
Author contributions: Author contributions: Wu B designed and revised the manuscript; Deng CL wrote the manuscript;
Abstract
We recently read with interest the article“ Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models”, this original article was using 2D/3D models of CRC demonstrating the efficacy of anti-tumor with Diiminoquinone (DQI). through further research and analysis, we feel obliged to offer some relevant insights. These comments may deepen our understanding in the context of the three-dimensional (3D) drug screening models and pathological subtypes have different responses to chemotherapies.
Keywords: Colorectal cancer, Diiminoquinone, 3D-bioprinting, Pathological subtypes, Drug screening
Core Tip: Colorectal cancer is one of the most prevalent cancers worldwide, for inoperable colorectal cancer, chemotherapy is the main treatment option. We recently read with interest the article” Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models”. We would like to share our opinion on this article and hope that it will be of some help to the authors and readers
TO THE EDITOR
We read with pleasure the article by Alissar Monzer et al. Within this article, the authors assessed the potential anti-tumor effects of Diiminoquinone（DIQ）in Colorectal cancer(CRC) two-dimensional (2D) or three-dimensional (3D) models. Furthermore, the in vivo anti-tumor ability assessment was evaluated using an in vivo model. The authors showed that DIQ could potentially be therapeutic, and inhibit proliferation, invasion, and migration of the tumor cells, by Wnt/-catenin and AKT and ERK pathways.
The salient highlight of this article was using multiple 3D models to independent validation of this compound for treatment in CRC. The tumor microenvironment provides essential signals to guide tumor growth and survival[1, 2]. The conventional 2D culture system has long been used in studies of chemotherapy responses. However, the 2D model cannot maintain the interactions of tumor cells, which further complicates the successful translation into the clinic. The authors successfully established the Sphere formation with tumor cell lines, the salient feature of Cancer stem cells (CSCs), and derived-organoid culture with colon tumor tissue. In subsequent studies, DIQ triggered selective tumor inhibition, but not of normal cells, which verified the safety and efficacy.
We found some details through further research and analysis and feel obliged to offer some relevant insights. The main role of 3D culture models aimed to mimic the native tumor microenvironment. Tumor microenvironment (TME) and intercellular communication can affect various signal transduction processes in cancer cells. The sphere formation assay is a classic functional approach for studying tumor stem cells. However, this method lack cell-to-cell communication in cancer cells and interstitial cells. 3D-printing is capable of fabricating complex 3D structures with multiple cell types, extracellular matrix components, and growth and signaling factors[3], we consider 3D-bioprinting can use multiple cell types in 3D architecture to better imitate the TME and then in developing more accurate therapeutic drug compared to 2D models[4]. Recently, various 3D-bioprinting drug screening models were reported to achieve higher predictive rates for drug response and novel drug development[2, 5]. Furthermore, 3D-bioprinting could as the foundation for future precision medicine for drug screening.
Another interesting finding by Alissar Monzer et al was the DIQ showed the chemotherapy sensitivity in mucinous neoplasms, special pathological subtypes in CRC[6]. The first‐line treatment in patients with metastatic colorectal cancer (mCRC) usually involves chemotherapy. Previous studies demonstrated that patients with mucinous tumors with lesser involves either irinotecan‐ or oxaliplatin‐based chemotherapy benefit with than patients with non-mucinous tumor[7]. In the following, the anti-tumor mechanism of DQI was proved that was activating γH2AX expression to inducer of DNA damage. However, due to the small size of the tissue sample and the low rate of deriving colon patient-derived organoids, the effectiveness of chemotherapy in mucinous tumors needs to be addressed with further research. This may provide directions for targeted therapy with differentiated subtype interventions.
In summary, this original article was using 2D/3D models of CRC demonstrating the efficacy of anti-tumor with DQI. However, in light of the complexity of CRC tumor and individual differences in patients, the detailed underlying mechanisms still need much more studies for rational and effective treatment innovation.
1 Habanjar O, Diab-Assaf M, Caldefie-Chezet F, Delort L. 3D Cell Culture Systems: Tumor Application, Advantages, and Disadvantages. Int J Mol Sci 2021; 22(22) [PMID: 34830082 PMCID: PMC8618305 DOI: 10.3390/ijms222212200]
2 Ramzy GM, Koessler T, Ducrey E, McKee T, Ris F, Buchs N, Rubbia-Brandt L, Dietrich PY, Nowak-Sliwinska P. Patient-Derived In Vitro Models for Drug Discovery in Colorectal Carcinoma. Cancers (Basel) 2020; 12(6) [PMID: 32486365 PMCID: PMC7352800 DOI: 10.3390/cancers12061423]
3 Sbirkov Y, Molander D, Milet C, Bodurov I, Atanasov B, Penkov R, Belev N, Forraz N, McGuckin C, Sarafian V. A Colorectal Cancer 3D Bioprinting Workflow as a Platform for Disease Modeling and Chemotherapeutic Screening. Front Bioeng Biotechnol 2021; 9: 755563 [PMID: 34869264 PMCID: PMC8638705 DOI: 10.3389/fbioe.2021.755563]
4 Neufeld L, Yeini E, Reisman N, Shtilerman Y, Ben-Shushan D, Pozzi S, Madi A, Tiram G, Eldar-Boock A, Ferber S, Grossman R, Ram Z, Satchi-Fainaro R. Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment. Sci Adv 2021; 7(34) [PMID: 34407932 PMCID: PMC8373143 DOI: 10.1126/sciadv.abi9119]
5 Ma K, Zhao T, Yang L, Wang P, Jin J, Teng H, Xia D, Zhu L, Li L, Jiang Q, Wang X. Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study. J Adv Res 2020; 23: 123-132 [PMID: 32099674 PMCID: PMC7030996 DOI: 10.1016/j.jare.2020.01.010]
6 Taieb J, Shi Q, Pederson L, Alberts S, Wolmark N, Van Cutsem E, de Gramont A, Kerr R, Grothey A, Lonardi S, Yoshino T, Yothers G, Sinicrope FA, Zaanan A, Andre T. Prognosis of microsatellite instability and/or mismatch repair deficiency stage III colon cancer patients after disease recurrence following adjuvant treatment: results of an ACCENT pooled analysis of seven studies. Ann Oncol 2019; 30(9): 1466-1471 [PMID: 31268130 PMCID: PMC7360150 DOI: 10.1093/annonc/mdz208]
7 Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res 2021; 81(21): 5523-5539 [PMID: 34417201 PMCID: PMC8563430 DOI: 10.1158/0008-5472.CAN-21-0897]
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Monzer A, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Gali-Muhtasib H, Abou-Kheir W. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models. World J Gastroenterol 2022; 28(33): 4787-4811 [PMID: 36156922 DOI: 10.3748/wjg.v28.i33.4787]
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"This article has the following shortcomings:
1. When the blood pressure increases and the heart rate slows down, the blood pressure ..."
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"This article has the following shortcomings:
1. When the blood pressure increases and the heart rate slows down, the blood pressure should be lowered first, but atropine should not be given. As a result, the blood pressure will further increase with the increase of the heart rate. The patient's basic heart rate will be 52 times/min, and after dropping to 41 times/min, after atropine was given, the heart rate maintained at 60-70 times/min, which shows that there are deficiencies in the treatment.
2. The patient did not have adrenal gland examination after operation, and pheochromocytoma could not be excluded."
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Jang MJ, Kim JH, Jeong HJ. Uncontrolled high blood pressure under total intravenous anesthesia with propofol and remifentanil: A case report. World J Clin Cases 2022; 10(26): 9411-9416 [PMID: 36159423 DOI: 10.12998/wjcc.v10.i26.9411]
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Sposito C, Citterio D, Virdis M, Battiston C, Droz Dit Busset M, Flores M, Mazzaferro V. Therapeutic strategies for post-transplant recurrence of hepatocellular carcinoma. World J Gastroenterol 2022; 28(34): 4929-4942 [PMID: 36160651 DOI: 10.3748/wjg.v28.i34.4929]
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"In the Table 1-5, the authors often use the P<0.0167; P<0.005; P<0.0083......which does not make any sense, P<0.05 already means it ..."
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"In the Table 1-5, the authors often use the P<0.0167; P<0.005; P<0.0083......which does not make any sense, P<0.05 already means it have statistical difference, or the authors can also say that P<0.01 if the difference is obvious. This leads to the results section a bit confusing somehow. "
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Jiao HB, Wang W, Guo MN, Su YL, Pang DQ, Wang BL, Shi J, Wu JH. Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer. World J Clin Cases 2022; 10(26): 9264-9275 [PMID: 36159417 DOI: 10.12998/wjcc.v10.i26.9264]
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Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761 [PMID: 36156927 DOI: 10.3748/wjg.v28.i33.4744]
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"Dear Editor,
I am wondering how the aim and the structure of this article can be the same as the structure of the article that ..."
[Read more]
"Dear Editor,
I am wondering how the aim and the structure of this article can be the same as the structure of the article that I submitted after the invitation, which was eventually not published after my withdrawal!
Kind regards,
Vasileios Athanasiou
"
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Garcia-Mansilla I, Zicaro JP, Martinez EF, Astoul J, Yacuzzi C, Costa-Paz M. Overview of the anterolateral complex of the knee. World J Clin Cases 2022; 10(24): 8474-8481 [PMID: 36157829 DOI: 10.12998/wjcc.v10.i24.8474]
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"This study provides an available perspective for prognosis evaluation of ICCs and HCC-CCs undergoing LT, which helps draw attention ..."
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"This study provides an available perspective for prognosis evaluation of ICCs and HCC-CCs undergoing LT, which helps draw attention to the accurate preoperative diagnosis of these patients."
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Brandão ABM, Rodriguez S, Fleck Jr AM, Marroni CA, Wagner MB, Hörbe A, Fernandes MV, Cerski CT, Coral GP. Propensity-matched analysis of patients with intrahepatic cholangiocarcinoma or mixed hepatocellular-cholangiocarcinoma and hepatocellular carcinoma undergoing a liver transplant. World J Clin Oncol 2022; 13(8): 688-701 [PMID: 36160465 DOI: 10.5306/wjco.v13.i8.688]
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Miao YD, Tang XL, Wang JT, Mi DH. Prognostic role of expression of angiogenesis markers in hepatocellular carcinoma: A bioinformatics analysis. World J Gastroenterol 2022; 28(30): 4221-4226 [PMID: 36157115 DOI: 10.3748/wjg.v28.i30.4221]
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Bartolini I, Nannini G, Risaliti M, Matarazzo F, Moraldi L, Ringressi MN, Taddei A, Amedei A. Impact of microbiota-immunity axis in pancreatic cancer management. World J Gastroenterol 2022; 28(32): 4527-4539 [PMID: 36157926 DOI: 10.3748/wjg.v28.i32.4527]
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Biswas S, Ray Banerjee E. Probiotic treatment of inflammatory bowel disease: Its extent and intensity. World J Immunol 2022; 12(2): 15-24 [DOI: 10.5411/wji.v12.i2.15]
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Biswas S, Ray Banerjee E. Probiotic treatment of inflammatory bowel disease: Its extent and intensity. World J Immunol 2022; 12(2): 15-24 [DOI: 10.5411/wji.v12.i2.15]
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Velikova T. Vaccines and autoimmunity during the COVID-19 pandemic. World J Immunol 2022; 12(2): 9-14 [DOI: 10.5411/wji.v12.i2.9]
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Santillo E, Migale M. Beta receptor blocker therapy for the elderly in the COVID-19 era. World J Clin Cases 2022; 10(23): 8088-8096 [PMID: 36159512 DOI: 10.12998/wjcc.v10.i23.8088]
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"Retrospective study
Small number of patients
No control group included
The cause of death is given in only one out of two ..."
[Read more]
"Retrospective study
Small number of patients
No control group included
The cause of death is given in only one out of two patients died
Findings not different from the prior publication quoted by the authors."
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Azam M, Hudgi A, Uy PP, Makhija J, Yap JEL. Safety of endoscopy in patients undergoing treatments with antiangiogenic agents: A 5-year retrospective review. World J Gastrointest Endosc 2022; 14(7): 416-423 [PMID: 36051996 DOI: 10.4253/wjge.v14.i7.416]
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"It is well prepared and organised article. However they used an expensive metallic stent instead of a cheaper silicone tube. It can ..."
[Read more]
"It is well prepared and organised article. However they used an expensive metallic stent instead of a cheaper silicone tube. It can be better to discuss other choises and why they chose stent."
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Cheng SL, Xie L, Wu HW, Zhang XF, Lou LL, Shen HZ. Metal stent combined with ileus drainage tube for the treatment of delayed rectal perforation: A case report. World J Clin Cases 2022; 10(23): 8406-8416 [PMID: 36159539 DOI: 10.12998/wjcc.v10.i23.8406]
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