Copyright ©The Author(s) 2018.
World J Methodol. Nov 29, 2018; 8(3): 17-36
Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Table 5 Allergen molecules of fungal origin1 used in singleplex and multiplex immunoassays[9,74,106-108]
Allergen moleculeBiological function, comments, CR
Ascomycetes fungi (Alternaria alternata, Cladosporium herbarum, Aspergillus fumigatus)
rAlt a 1Fungal beta-barrel protein, detected in spores before germination
Involvement in Alternaria-spinach syndrome
rAlt a 6Fungal enolase, panallergen CR Cla h 6, Asp f 22, Pen c 22
rCla h 8Fungal mannitol dehydrogenase, major allergen, CR Alt a 8
rAsp f 1Fungal ribotoxin, specific major allergen, member of the mitogillin family
Not present in spores, but produced after germination and growth
Genuine exposure and IgE sensitization to A. fumigatus germinated in the respiratory tract
rAsp f 2Species-specific allergen component, with high frequency of sensitization among patients affected by ABPA
rAsp f 3 rAsp f 4Fungal peroxisomal protein, CR Pen c 3
Fungal protein, highly specific allergen
With high frequency of sensitization among ABPA patients
rAsp f 6Fungal Mn-SOD, CR Alt a 14, Mala s 11