Copyright ©The Author(s) 2018.
World J Methodol. Nov 29, 2018; 8(3): 17-36
Published online Nov 29, 2018. doi: 10.5662/wjm.v8.i3.17
Table 2 Allergen molecules of house dust and storage mites origin1 used in singleplex and multiplex immunoassays[9,74,102,103]
Allergen moleculeBiological function, comments, CR
House dust mites (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Euroglyphus maynei, Blomia tropicalis)
nDer p 1 rDer f 1Cysteine-protease, cleavage of regulatory IgE synthesis CD23, CD25 Midgut (colon, intercolon, postcolon) and mite fecal pellets Group 1 major mite allergen, CR with nDer f 1
rDer p 2 nDer p 2 rEur m 2Functional homologue of adaptor MD-2, TLR4 coreceptor Midgut (ventriculus, paired caeca), male reproductive tract, fecal pellets Group 2 major mite allergen, NPC2 family, CR Der p 2, Der f 2, homologue Lep d 2
rDer p 4Group 4 major mite allergen
rDer p 5Group 5 major mite allergen, homologue rBlo t 5
rDer p 7LPS-binding protein, stimulation TLR2, group 7 mite allergen
rDer p 9Serine protease, group 9 mite allergen
rDer p 10Invertebrate panallergen tropomyosin muscular protein from mite locomotory muscles Group 10 CR mite allergen, invertebrate panallergen CR rAni s 3, nBla g 7, rPer a 7, rPen a 1, Pen m 1, Lit v 1, Hel as 1, Ven g 1, Uro du 1 Involved in house dust mites-crustaceans-mollusks syndrome
rDer p 11Paramyosin, major allergen
rDer p 14Apolipophorin-like allergen, lipid transport particles
rDer p 15 rDer p 18Chitinase-like allergens
nDer p 20Arginine kinase, CR shrimp Penaeus monodon Pen m 2
rDer p 21Group 21 mite allergen, gut and fecal particles
rDer p 23Peritrophin-like protein (8 kDa), group 23 mite major allergen Peritrophic lining of mite gut, fecal pellets
Storage mites (Glycyphagus domesticus, etc.)
rGly d 2Group 2 mite allergens, NPC2 protein CR Lep d 2, homologue Der p 2 (limited CR)