Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

Table 2 Mean duration of tonic hind limb extension in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	Mean duration of tonic hind limb extension (seconds)	SEM
Vehicle (control group)	6.73	0.51
Carbamazepine 4 mg/kg	0a	0
Carbamazepine 6 mg/kg	0a	0
Carbamazepine 8 mg/kg	0a	0
Rosuvastatin 10 mg/kg	5.80	1.18
Rosuvastatin 20 mg/kg	4.47	1.41
Rosuvastatin 30 mg/kg	4.93	1.58
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	0a	0

^aP value < 0.05 in comparison with control group (Dunn Post hoc analysis).