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World J Methodol. May 20, 2022; 12(3): 164-178
Published online May 20, 2022. doi: 10.5662/wjm.v12.i3.164
Participant attrition and perinatal outcomes in prenatal vitamin D-supplemented gestational diabetes mellitus patients in Asia: A meta-analysis
Sumanta Saha, Sujata Saha
Sumanta Saha, Department of Community Medicine, R. G. Kar Medical College, Kolkata 700004, West Bengal, India
Sujata Saha, Department of Mathematics, Mankar College, Mankar 713144, West Bengal, India
Author contributions: Sumanta Saha conceptualized, designed, analyzed, and drafted the first and final versions of the manuscript; all authors contributed to the study selection, data abstraction, and risk of bias assessment of this manuscript; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare there are no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2020 statement Checklist, and the manuscript was prepared and revised according to the PRISMA 2020 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Sumanta Saha, DNB, MBBS, Doctor, Teacher, Department of Community Medicine, R. G. Kar Medical College, Kolkata, 700004 West Bengal India, Kolkata 700004, West Bengal, India.
Received: December 1, 2021
Peer-review started: December 1, 2021
First decision: January 12, 2022
Revised: January 20, 2022
Accepted: March 26, 2022
Article in press: March 26, 2022
Published online: May 20, 2022
Core Tip

Core Tip: This meta-analysis was conducted on efficacy trials testing the effect of vitamin D in gestational diabetes mellitus (GDM) patients and/or their neonates. The post-randomization attrition burden of GDM patients from vitamin D-supplemented trial arms was low. The risk of hyperbilirubinemia and hospitalization in newborns was low with vitamin D and its omega-3 fatty acids and calcium co-supplemented forms. Vitamin D co-supplementation with calcium and probiotics reduced the risk of cesarean section and newborn hyperbilirubinemia, respectively. Compared to omega-3 fatty acids, the risk of hyperbilirubinemia and hospitalization among neonates was low when it was co-supplemented with vitamin D.