Partial heart transplantation: Current applications and management

doi:10.5528/wjtm.124968

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World Journal of Translational Medicine

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2220-6132

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Transl Med. Nov 28, 2026; 12(4): 124968
Published online Nov 28, 2026. doi: 10.5528/wjtm.124968

Partial heart transplantation: Current applications and management

Thomas Miller Sisson, Kevin Dennis Hill, Seth EM Wolf, Joseph W Turek, Douglas M Overbey, Erin V Shea

Thomas Miller Sisson, Kevin Dennis Hill, Erin V Shea, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, United States

Seth EM Wolf, Joseph W Turek, Douglas M Overbey, Department of Surgery, Duke University Medical Center, Durham, NC 27510, United States

Co-first authors: Thomas Miller Sisson and Kevin Dennis Hill.

Author contributions: Sisson TM and Hill KD drafted the manuscript and contributed equally to its development; Sisson TM, Hill KD, and Shea EV reviewed and analyzed the literature; Sisson TM created original figures and tables; Hill KD, Wolf SEM, Turek JW, Overbey DM, and Shea EV revised and critically appraised the manuscript; and all authors approved the final version to be published and agreed to be accountable for all aspects of the work.

AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript. No AI tools were used in the development of this manuscript or its constituent parts.

Supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health, No. T32HL176430.

Conflict-of-interest statement: Joseph W Turek is an equity stakeholder in Surge Ingenuity, Inc. The other authors do not have any conflicts of interest to disclose.

Corresponding author: Kevin Dennis Hill, MD, MSCI, Professor, Department of Pediatrics, Duke University Medical Center, DUMC Box 3090, Durham, NC 27710, United States. kevin.hill@duke.edu

Received: June 29, 2026
Revised: September 2, 2026
Accepted: October 10, 2026
Published online: November 28, 2026
Processing time: 130 Days and 9 Hours

Core Tip

Core Tip: Partial heart transplantation is a promising surgical innovation to treat pediatric heart valve dysfunction. The short-term outcomes are encouraging, demonstrating valvular growth and function with low rate of complications.