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World J Transl Med. Nov 28, 2026; 12(4): 123849
Published online Nov 28, 2026. doi: 10.5528/wjtm.123849
Published online Nov 28, 2026. doi: 10.5528/wjtm.123849
Heterogeneity-oriented multidisciplinary and super-minimally invasive precision treatment framework for locally advanced gastric cancer
Qian-Qian Chen, Jia-Yan Zhou, En-Qiang Linghu, Department of Gastroenterology, The First Medical Center, General Hospital of the Chinese PLA, Beijing 100853, China
Co-first authors: Chen QQ and Zhou JY.
Author contributions: Chen QQ and Zhou JY contributed equally to this work as co-first authors; Linghu EQ supervised the study; all authors reviewed and approved the final manuscript.
AI contribution statement: We used DeepSeek to revise the language of the article in English.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Corresponding author: En-Qiang Linghu, MD, PhD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center, General Hospital of the Chinese PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Received: June 1, 2026
Revised: July 18, 2026
Accepted: September 4, 2026
Published online: November 28, 2026
Processing time: 158 Days and 15 Hours
Revised: July 18, 2026
Accepted: September 4, 2026
Published online: November 28, 2026
Processing time: 158 Days and 15 Hours
Core Tip
Core Tip: Heterogeneity-oriented multidisciplinary team planning and super minimally invasive precision resection is an investigational heterogeneity-oriented framework, not a substitute for standard D2 gastrectomy. The central requirement of this concept is that any function-preserving local intervention must also achieve adequate control of the full gastric wall, the serosal-peritoneal interface, and regional lymph nodes. Endoscopy alone cannot meet these requirements in cT3-T4a disease; therefore, implementation would require a carefully selected, combined endoscopic-laparoscopic pathway and prospective validation.