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World J Transl Med. Sep 28, 2026; 12(3): 124909
Published online Sep 28, 2026. doi: 10.5528/wjtm.124909
Published online Sep 28, 2026. doi: 10.5528/wjtm.124909
Long-term adipocytokine changes after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: A comparative minireview
Ahmed Salman, Department of Internal Medicine, Kasr Alainy School of Medicine, Cairo 11562, Egypt
Mohamed AbdAlla Salman, Department of General Surgery, Kasralainy School of Medicine, Cairo 11562, Egypt
Author contributions: Salman A contributed to the study conception, literature review, manuscript drafting, and critical revision; Salman MA contributed to data interpretation and critical revision; and both authors approved the final version of the manuscript.
AI contribution statement: OpenAI Codex (GPT-6.5) was used for language editing, formatting, and organization of the revision. It was not used to generate research data. The authors reviewed and revised all AI-assisted text and take responsibility for the manuscript’s accuracy, originality, and integrity.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Corresponding author: Ahmed Salman, FRACP, FRCP, Department of Internal Medicine, Kasr Alainy School of Medicine, 1 Al-Saray Street, Al-Manial, Cairo 11562, Egypt.
Received: June 29, 2026
Revised: August 4, 2026
Accepted: August 17, 2026
Published online: September 28, 2026
Processing time: 69 Days and 13.5 Hours
Revised: August 4, 2026
Accepted: August 17, 2026
Published online: September 28, 2026
Processing time: 69 Days and 13.5 Hours
Core Tip
Core Tip: Direct comparisons indicate that Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy produce broadly similar long-term reductions in leptin and chemerin. Adiponectin increases after both procedures; a greater post-RYGB increase has been reported in some small cohorts but is not consistent across studies. Evidence for resistin is limited. Because postoperative weight loss, baseline diabetes, supplementation, and assay differences confound comparisons, current adipokine data cannot determine the preferred operation or predict individual outcomes. Larger randomized studies with standardized measurements and > 1-year follow-up are needed.