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World J Transl Med. Sep 28, 2026; 12(3): 124281
Published online Sep 28, 2026. doi: 10.5528/wjtm.124281
Published online Sep 28, 2026. doi: 10.5528/wjtm.124281
Application of the fibrosis-4 score in a generalised population
Hendrik F Conradie, Department of Medicine, St Richard’s Hospital, Chichester PO19 6SE, West Sussex, United Kingdom
Kate Shipman, Chemical Pathology, St Richard’s Hospital, Chichester PO19 6SE, West Sussex, United Kingdom
Co-first authors: Hendrik F Conradie and Kate Shipman.
Author contributions: Shipman K located the data; Shipman K and Conradie HF both interpreted the data, wrote the article, located references, and edited the text, thus qualified as the co-first authors of the paper; revisions were made by Conradie HF.
AI contribution statement: AI tools, specifically ChatGPT, were used solely for language polishing. No AI tool was used to generate research data, interpret results, or formulate conclusions. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.
Institutional review board statement: Study did not meet criteria to be reviewed by ethics committee. No participants were recruited for this study. All data were anonymised. Evaluation of service data is exempt from requiring ethical approval.
Informed consent statement: No identifiable patient data was analysed or published; informed consent was therefore not collected from subjects as no participation was sought and data were anonymised.
Conflict-of-interest statement: Neither author has any conflict of interest to declare.
Data sharing statement: Data were generated for this study. Anonymised data can be made available as per General Data Protection Regulation (GDPR) regulations. Please contact the author if wish to discuss.
Corresponding author: Hendrik F Conradie, MD, Department of Medicine, St Richard’s Hospital, Spitalfield Lane, Chichester PO19 6SE, West Sussex, United Kingdom.
Received: June 11, 2026
Revised: July 27, 2026
Accepted: August 10, 2026
Published online: September 28, 2026
Processing time: 84 Days and 18.9 Hours
Revised: July 27, 2026
Accepted: August 10, 2026
Published online: September 28, 2026
Processing time: 84 Days and 18.9 Hours
Core Tip
Core Tip: The fibrosis-4 (FIB-4) score is used indiscriminately and when applied inappropriately may lead to misleading results and diagnostic noise. This study shows how different a generalised population is from the population on which the FIB-4 score was validated. Other adaptations of the FIB-4 score exist that have shown diagnostic superiority on specific po