Vascular response to vasodilator treatment in microalbuminuric diabetic kidney disease

Table 1 Renal function and intrarenal hemodyamic study in microalbuminuric type 2 diabetic kidney disease

	Healthy Subject	Initial value in Microal-buminuricpatients	P value
Renal function
Microalbumin/creatinine ratio, μg/mg	< 30	170 ± 193	0.010
Creatinine clearance, mL/min per 1.73 m2	117 ± 13	73 ± 28	0.001
Fractional excretion of magnesium, %	1.6 ± 2.2	4.1 ± 1	0.050
Mean arterial pressure, mmHg	79	99 ± 5	0.001
Renal hemodynamics
Renal plasma flow, mL/min per 1.73 m2	585 ± 30	505 ± 120	NS
Peritubular capillary flow, mL/min per 1.73 m2	479 ± 26	423 ± 120	NS
Glomerular filtration rate, mL/min per 1.73 m2	116 ± 14	82 ± 6	0.010
Afferent arteriolar resistance, dyne.s.cm-5	2331 ± 108	2841 ± 299	0.050
Efferent arteriolar resistance, dyne.s.cm-5	3012 ± 130	4045 ± 1168	NS

NS: Not significant.

Table 2 Follow-up value of intrarenal hemodynamic study in microalbuminuric diabetic kidney disease

	Pre-treatment	Post-treatment	Pvalue
Renal function
Creatinine clearance, mL/min per 1.73 m2	73 ± 28	80 ± 37	NS
Fractional excretion of magnesium, %	4.1 ± 1	4.2 ± 2	NS
Microalbumin/creatinine ratio, μg/mg	170 ± 193	109 ± 148	NS
Mean arterial pressure, mmHg	99 ± 5	85 ± 14	< 0.05
Hemodynamics
Renal plasma flow , mL/min per 1.73 m2	505 ± 120	416 ± 9	NS
Peritubular capillary flow, mL/min per 1.73 m2	423 ± 120	350 ± 13	NS
Glomerular filtration rate, mL/min per 1.73 m2	82 ± 6	75 ± 9	NS
Afferent arteriolar resistance, dyne.s.cm-5	2842 ± 299	3359 ± 1587	NS
Efferent arteriolar resistance, dyne.s.cm-5	4045 ± 1168	4093 ± 53	NS

NS: Not significant.