Kinin B2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis

Figure 1 Serum and urinary parameters. A: S_{Cr l}evels (^aP < 0.05 vs B₂KO, ^bP < 0.01 vs WT); B: U_Cr levels; C: BUN levels (^bP < 0.005 vs WT, ^dP < 0.01 vs B₂KO); D: Urinary urea (^bP < 0.01 vs WT, ^dP < 0.005 vs B₂KO); E: Total urine proteins (^bP < 0.005 vs WT, ^dP < 0.005 vs B₂KO). WT: Wild type; B₂KO: Kinin B2 receptor knockout mice; GWT: Glycerol wild type; B₂KO: Glycerol kinin B2 receptor knockout mice; BUN: Blood urea nitrogen.

Figure 2 Renal gene expression and association between genes. A: B₂R fold change (^bP < 0.01 vs WT); B: B₁R fold change (^aP < 0.05 vs B₂KO); C: Association between B₂R and B₁R; D: Association between IL-1β and B₁R; E: Association between TGF-β1 and B₁R. WT: Wild type; B₂KO: Kinin B2 receptor knockout mice; GWT: Glycerol wild type; GB₂KO: Glycerol kinin B2 receptor knockout mice; BUN: Blood urea nitrogen.

Figure 3 Histological evaluation and Graphs show the degrees of renal injury. A: Degree I; B: Degree II; C: Degree III; D: Degree IV; E: WT; F: GWT; G: B₂KO; H: GB₂KO. WT: Wild type; B₂KO: Kinin B2 receptor knockout mice; GWT: Glycerol wild type; GB₂KO: Glycerol kinin B2 receptor knockout mice;