Copyright ©2013 Baishideng Publishing Group Co.
World J Nephrol. Aug 6, 2013; 2(3): 56-76
Published online Aug 6, 2013. doi: 10.5527/wjn.v2.i3.56
Figure 1
Figure 1 Pathogenetic mechanisms of thrombotic microangiopathy. MCP: Membrane cofactor protein.
Figure 2
Figure 2 Diagnostic algorithm to distinguish among different Hemolytic uremic syndrome. HUS: Hemolytic uremic syndrome; E. coli: Escherichia coli.
Figure 3
Figure 3 Alternative pathway. The alternative pathway is triggered by spontaneous activation of C3. Activation of this pathway leads to MAC formation which results in cell lysis (in red complement regulatory proteins; in black complement activating factors). CFH: Complement factor H; CFI: Complement factor I; DAF: Decay accelerating factor; MAC: Membrane attack complex; MCP: Membrane cofactor protein; THBD: Thrombomodulin.
Figure 4
Figure 4 Complement regulatory factors. CR1: Complement receptor 1; DAF: Decay-accelerating factor; MCP: Membrane cofactor of proteolysis.