Update on hemolytic uremic syndrome: Diagnostic and therapeutic recommendations

Figure 1 Pathogenetic mechanisms of thrombotic microangiopathy. MCP: Membrane cofactor protein.

Figure 2 Diagnostic algorithm to distinguish among different Hemolytic uremic syndrome. HUS: Hemolytic uremic syndrome; E. coli: Escherichia coli.

Figure 3 Alternative pathway. The alternative pathway is triggered by spontaneous activation of C3. Activation of this pathway leads to MAC formation which results in cell lysis (in red complement regulatory proteins; in black complement activating factors). CFH: Complement factor H; CFI: Complement factor I; DAF: Decay accelerating factor; MAC: Membrane attack complex; MCP: Membrane cofactor protein; THBD: Thrombomodulin.

Figure 4 Complement regulatory factors. CR1: Complement receptor 1; DAF: Decay-accelerating factor; MCP: Membrane cofactor of proteolysis.