Update on hemolytic uremic syndrome: Diagnostic and therapeutic recommendations

Figure 3 Alternative pathway. The alternative pathway is triggered by spontaneous activation of C3. Activation of this pathway leads to MAC formation which results in cell lysis (in red complement regulatory proteins; in black complement activating factors). CFH: Complement factor H; CFI: Complement factor I; DAF: Decay accelerating factor; MAC: Membrane attack complex; MCP: Membrane cofactor protein; THBD: Thrombomodulin.