Collapsing focal segmental glomerulosclerosis: Current concepts

Figure 1 High magnification view showing global collapse of capillary tufts associated with marked hypertrophy and hyperplasia of podocytes (arrow), forming a pseudo-crescent. Marked cytoplasmic vacuolization and protein resorption droplets (arrowhead) are seen in podocytes. Jones’ methenamine silver, × 400.

Figure 2 Medium-power view showing marked tubular atrophy associated with interstitial fibrosis and mononuclear inflammatory cell infiltrate in the interstitium. Many dilated tubules contain eosinophilic casts. One glomerulus shows ischemic solidification and another one, global collapse with podocyter hypertrophy but little podocyte proliferation (arrow). Jones’ methenamine silver, × 200.