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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Nephrol. Jul 6, 2017; 6(4): 217-220
Published online Jul 6, 2017. doi: 10.5527/wjn.v6.i4.217
Published online Jul 6, 2017. doi: 10.5527/wjn.v6.i4.217
Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis
Pasquale Esposito, Maria Valentina Domenech, Nicoletta Serpieri, Marta Calatroni, Ilaria Massa, Alessandro Avella, Edoardo La Porta, Luca Estienne, Elena Caramella, Teresa Rampino, Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico “San Matteo” and University of Pavia, 27100 Pavia, Italy
Author contributions: All authors contributed equally in data acquisition, analysis and interpretation of the data, drafting and critical revision of the manuscript.
Institutional review board statement: This case report was exempt from the Institutional Review Board standards at University Hospital of Pavia.
Informed consent statement: The patient involved in this study gave his written informed consent authorizing use and disclosure of his protected health information.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pasquale Esposito, MD, PhD, Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico “San Matteo” and University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. p.esposito@smatteo.pv.it
Telephone: +39-3-82503883 Fax: +39-3-82503883
Received: January 26, 2017
Peer-review started: February 8, 2017
First decision: March 31, 2017
Revised: April 12, 2017
Accepted: June 6, 2017
Article in press: June 8, 2017
Published online: July 6, 2017
Peer-review started: February 8, 2017
First decision: March 31, 2017
Revised: April 12, 2017
Accepted: June 6, 2017
Article in press: June 8, 2017
Published online: July 6, 2017
Core Tip
Core tip: The syndrome of inappropriate antidiuresis (SIAD) is a disorder of sodium and water balance characterized by hypotonic hyponatremia and impaired urinary dilution in the absence of renal disease or any non-osmotic stimulus known to release anti-diuretic hormone. It may be caused by several conditions including infections, neoplasms and use of some medications, such as antipsychotics, antidepressant and immunosuppressive drugs. Here, we report the clinical course of a case of SIAD attributed to administration of a single low-dose of intravenous cyclophosphamide in a patient with an acute glomerulonephritis.