Copyright
©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Acute kidney injury following spinal instrumentation surgery in children
Jasper J Jöbsis, Department of Paediatrics, Tergooi Hospital, 1261 AN Blaricum, The Netherlands
Abdullah Alabbas, Stollery Children’s Hospital, Edmonton, AB T6G 2L9, Canada
Ruth Milner, Christopher Reilly, Kishore Mulpuri, Cherry Mammen, BC Children’s Hospital, Vancouver, BC V6H 3V4, Canada
Author contributions: Jöbsis JJ and Allabas A contributed equally in data collection and drafting the manuscript; Mammen C designed and supervised the study; Reilly C and Mulpuri K revised the manuscript for important intellectual content; Milner R offered statistical support; all authors have read and approved the final version to be published.
Institutional review board statement: This study is retrospective, involving anonymous clinical data without affecting the patient’s rights and welfare. The study was reviewed and approved by the BC Children’s Hospital/University of British Columbia Institutional Review Board.
Informed consent statement: As per the BC Children’s Hospital Institutional Review Board, informed consent was not required for this retrospective study. Subjects are not identifiable from any data presented in this manuscript.
Conflict-of-interest statement: None of the authors have any conflicts of interest related to this research topic.
Data sharing statement: Technical appendix, statistical code and dataset available from the corresponding author at jjobsis@tergooi.nl. Informed consent was not obtained, but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jasper J Jöbsis, MD, Department of Paediatrics, Tergooi Hospital, Rijksstraatweg 1, 1261 AN Blaricum, The Netherlands. jjobsis@tergooi.nl
Telephone: +31-88-7531753 Fax: +31-88-7531168
Received: June 5, 2016
Peer-review started: June 9, 2016
First decision: July 5, 2016
Revised: December 23, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 6, 2017
Peer-review started: June 9, 2016
First decision: July 5, 2016
Revised: December 23, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: March 6, 2017
Core Tip
Core tip: We are the first to report a high incidence of acute kidney injury (AKI) of 17% in children undergoing orthopaedic spinal instrumentation surgery utilizing the Acute Kidney Injury Network definition. A relationship was observed between the development of AKI and the use of nephrotoxins including non-steroidal anti-inflammatory drugs and lower amounts of intravenous fluid administered peri-operatively. These results suggest that there are modifiable AKI risk factors with the potential of reducing AKI incidence in this understudied population. Further prospective studies with the use of novel AKI biomarkers are needed to validate our novel results.