Ohno Y, Kanno Y, Takenaka T. Central blood pressure and chronic kidney disease. World J Nephrol 2016; 5(1): 90-100 [PMID: 26788468 DOI: 10.5527/wjn.v5.i1.90]
Corresponding Author of This Article
Tsuneo Takenaka, MD, PhD, Department of Medicine, International University of Health and Welfare, Clinical Research Center, Sanno Hospital, 8-10-16 Akasaka Minato, Tokyo 107-0052, Japan. takenaka@iuhw.ac.jp
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Nephrol. Jan 6, 2016; 5(1): 90-100 Published online Jan 6, 2016. doi: 10.5527/wjn.v5.i1.90
Central blood pressure and chronic kidney disease
Yoichi Ohno, Yoshihiko Kanno, Tsuneo Takenaka
Yoichi Ohno, Department of Nephrology, Saitama Medical University, Saitama 350-0495, Japan
Yoshihiko Kanno, Department of Nephrology, Tokyo Medical University, Tokyo 160-0023, Japan
Tsuneo Takenaka, Department of Medicine, International University of Health and Welfare, Clinical Research Center, Sanno Hospital, Tokyo 107-0052, Japan
Author contributions: All authors equally contributed to this paper with conception and design of the study, acquisition and analysis of the data, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Tsuneo Takenaka, MD, PhD, Department of Medicine, International University of Health and Welfare, Clinical Research Center, Sanno Hospital, 8-10-16 Akasaka Minato, Tokyo 107-0052, Japan. takenaka@iuhw.ac.jp
Telephone: +81-3-34023151 Fax: +81-3-34043652
Received: August 30, 2015 Peer-review started: August 31, 2015 First decision: October 27, 2015 Revised: November 17, 2015 Accepted: December 13, 2015 Article in press: December 14, 2015 Published online: January 6, 2016
Core Tip
Core tip: Wave reflection is a major mechanism that determines central blood pressure in chronic kidney disease (CKD). Diminished renal autoregulatory ability characterizes CKD, allowing an increase in proteinuria. Thus, any elevations of central blood pressure accelerate the progression of CKD. The kidney produces oxidative stress compounds due to proteinuria handling and secondary interstitial inflammation. Oxidative stress facilitates atherogenesis, increases arterial stiffness and central blood pressure. Furthermore, even in early stages of CKD, mineral and bone disorder (MBD) is developed. CKD-MBD facilitates to induce oxidative stress and elevation of central blood pressure. To keep vascular health in CKD, early intervention or prevention seems mandatory.
